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L01E Protein kinase inhibitors, antineoplastic and immunomodulating agents

ATC group of level 3 – pharmacological subgroup · in plain English: targeted cancer medicines (kinase inhibitors)

This site has the patient leaflet or the SPC of 353 medicines in this group and its subgroups.

Place in the ATC classification

  1. L Antineoplastic and immunomodulating agents 1,791 medicines
    1. L01 Antineoplastic agents 1,025 medicines
      1. L01E Protein kinase inhibitors, antineoplastic and immunomodulating agents 353 medicines
        1. L01EA BCR-ABL tyrosine kinase inhibitors 101 medicines
        2. L01EB Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors 40 medicines
        3. L01EC B-Raf serine-threonine kinase (BRAF) inhibitors 6 medicines
        4. L01ED Anaplastic lymphoma kinase (ALK) inhibitors 14 medicines
        5. L01EE Mitogen-activated protein kinase (MEK) inhibitors 10 medicines
        6. L01EF Cyclin-dependent kinase (CDK) inhibitors 13 medicines
        7. L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors 27 medicines
        8. L01EH Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors 4 medicines
        9. L01EJ Janus-associated kinase (JAK) inhibitors 18 medicines
        10. L01EK Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors 12 medicines
        11. L01EL Bruton's tyrosine kinase (BTK) inhibitors 8 medicines
        12. L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors 6 medicines
        13. L01EX Other protein kinase inhibitors 94 medicines

Medicines in the group and its subgroups

MedicineLegal category
Tafinlar 50 mg hard capsules SPC (L01EC02 dabrafenib) Prescription only (POM)
Tafinlar 75 mg hard capsules SPC (L01EC02 dabrafenib) Prescription only (POM)
Tagrisso 40 mg film-coated tablets (L01EB04 osimertinib) Prescription only (POM)
Tagrisso 80 mg film-coated tablets (L01EB04 osimertinib) Prescription only (POM)
Tarceva 100 mg film coated tablets SPC (L01EB02 erlotinib) Prescription only (POM)
Tarceva 150 mg film-coated tablets SPC no longer supplied (L01EB02 erlotinib) –
Tarceva 25 mg film-coated tablets SPC no longer supplied (L01EB02 erlotinib) –
Tasigna 150 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Tasigna 200 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Tasigna 50 mg hard capsules (L01EA03 nilotinib) Prescription only (POM)
Tepmetko 225 mg film-coated tablets SPC (L01EX21 tepotinib) Prescription only (POM)
Torisel 30 mg concentrate and solvent for solution for infusion SPC (L01EG01 temsirolimus) Prescription only (POM)
Tukysa 150 mg film-coated tablets SPC (L01EH03 tucatinib) Prescription only (POM)
Tukysa 50 mg film coated tablets (L01EH03 tucatinib) Prescription only (POM)
Tyverb 250 mg film-coated tablets SPC (L01EH01 lapatinib) Prescription only (POM)
Uxil 110.6 mg film-coated tablets no longer supplied (L01EA02 dasatinib) –
Uxil 15.8 mg film-coated tablets SPC no longer supplied (L01EA02 dasatinib) –
Uxil 39.5 mg film-coated tablets SPC no longer supplied (L01EA02 dasatinib) –
Uxil 55.3 mg film-coated tablets SPC no longer supplied (L01EA02 dasatinib) –
Uxil 63.2 mg film-coated tablets no longer supplied (L01EA02 dasatinib) –
Uxil 79 mg film-coated tablets no longer supplied (L01EA02 dasatinib) –
Vanflyta 26.5 mg film-coated tablets SPC (L01EX11 quizartinib) Prescription only (POM)
Vargatef 100 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Vargatef 150 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Verzenios 100 mg film-coated tablets SPC (L01EF03 abemaciclib) Prescription only (POM)
Verzenios 150 mg film-coated tablets SPC (L01EF03 abemaciclib) Prescription only (POM)
Verzenios 50 mg film-coated tablets SPC (L01EF03 abemaciclib) Prescription only (POM)
Vitrakvi 100 mg hard capsules SPC (L01EX12 larotrectinib) Prescription only (POM)
Vitrakvi 20 mg / ml oral solution SPC (L01EX12 larotrectinib) –
Vitrakvi 25 mg hard capsules SPC (L01EX12 larotrectinib) Prescription only (POM)
Vizimpro 15 mg film-coated tablets SPC (L01EB07 dacomitinib) Prescription only (POM)
Vizimpro 30 mg film-coated tablets SPC (L01EB07 dacomitinib) Prescription only (POM)
Vizimpro 45 mg film-coated tablets SPC (L01EB07 dacomitinib) Prescription only (POM)
Votrient 200 mg film-coated tablets SPC (L01EX03 pazopanib) Prescription only (POM)
Votrient 400 mg film-coated tablets SPC (L01EX03 pazopanib) Prescription only (POM)
Votubia 1 mg dispersible tablets SPC (L01EG02 everolimus) Prescription only (POM)
Votubia 10 mg tablets SPC (L01EG02 everolimus) Prescription only (POM)
Votubia 2 mg dispersible tablets SPC (L01EG02 everolimus) Prescription only (POM)
Votubia 2.5 mg tablets SPC (L01EG02 everolimus) Prescription only (POM)
Votubia 3 mg dispersible tablets (L01EG02 everolimus) Prescription only (POM)
Votubia 5 mg dispersible tablets SPC (L01EG02 everolimus) Prescription only (POM)
Votubia 5 mg tablets SPC (L01EG02 everolimus) Prescription only (POM)
Xalkori 150 mg granules in capsules for Opening SPC (L01ED01 crizotinib) Prescription only (POM)
Xalkori 20 mg granules in capsules for Opening SPC (L01ED01 crizotinib) Prescription only (POM)
Xalkori 200 mg hard capsules SPC (L01ED01 crizotinib) Prescription only (POM)
Xalkori 250 mg hard capsules SPC (L01ED01 crizotinib) Prescription only (POM)
Xalkori 50 mg granules in capsules for Opening (L01ED01 crizotinib) Prescription only (POM)
Xospata 40 mg film-coated tablets SPC (L01EX13 gilteritinib) Prescription only (POM)
Zelboraf 240 mg film-coated tablets SPC (L01EC01 vemurafenib) Prescription only (POM)
Zydelig 100 mg film-coated tablets SPC (L01EM01 idelalisib) Prescription only (POM)
Zydelig 150 mg film-coated tablets SPC (L01EM01 idelalisib) Prescription only (POM)
Zykadia 150 mg film-coated tablets SPC (L01ED02 ceritinib) Prescription only (POM)
Zykadia 150 mg hard capsules SPC no longer supplied (L01ED02 ceritinib) –

Sources

  • Patient leaflets and SPCs: the MHRA product information (products.mhra.gov.uk) and the European Medicines Agency (EMA)
  • Active substances, ATC codes and legal categories: the NHS Dictionary of Medicines and Devices (dm+d), NHS Business Services Authority
  • World Health Organization (WHO): ATC/DDD classification, group L01E

Contains public sector information licensed under the Open Government Licence v3.0.

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