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L01E Protein kinase inhibitors, antineoplastic and immunomodulating agents

ATC group of level 3 – pharmacological subgroup · in plain English: targeted cancer medicines (kinase inhibitors)

This site has the patient leaflet or the SPC of 353 medicines in this group and its subgroups.

Place in the ATC classification

  1. L Antineoplastic and immunomodulating agents 1,791 medicines
    1. L01 Antineoplastic agents 1,025 medicines
      1. L01E Protein kinase inhibitors, antineoplastic and immunomodulating agents 353 medicines
        1. L01EA BCR-ABL tyrosine kinase inhibitors 101 medicines
        2. L01EB Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors 40 medicines
        3. L01EC B-Raf serine-threonine kinase (BRAF) inhibitors 6 medicines
        4. L01ED Anaplastic lymphoma kinase (ALK) inhibitors 14 medicines
        5. L01EE Mitogen-activated protein kinase (MEK) inhibitors 10 medicines
        6. L01EF Cyclin-dependent kinase (CDK) inhibitors 13 medicines
        7. L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors 27 medicines
        8. L01EH Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors 4 medicines
        9. L01EJ Janus-associated kinase (JAK) inhibitors 18 medicines
        10. L01EK Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors 12 medicines
        11. L01EL Bruton's tyrosine kinase (BTK) inhibitors 8 medicines
        12. L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors 6 medicines
        13. L01EX Other protein kinase inhibitors 94 medicines

Medicines in the group and its subgroups

MedicineLegal category
Mekinist 0.5 mg film-coated tablets SPC (L01EE01 trametinib) Prescription only (POM)
Mekinist 2 mg film-coated tablets SPC (L01EE01 trametinib) Prescription only (POM)
Mektovi 15 mg film-coated tablets SPC (L01EE03 binimetinib) Prescription only (POM)
Mektovi 45 mg film-coated tablets (L01EE03 binimetinib) Prescription only (POM)
Nerlynx 40 mg film-coated tablets SPC (L01EH02 neratinib) Prescription only (POM)
Nexavar 200 mg film-coated tablets SPC (L01EX02 sorafenib) Prescription only (POM)
Nibix 100 mg capsule hard SPC no longer supplied (L01EA01 imatinib) –
Nibix 400 mg hard capsules SPC no longer supplied (L01EA01 imatinib) –
Nilotinib 150 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Nilotinib 200 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Nilotinib 50 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Nilotinib Torrent 150 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Nilotinib Torrent 200 mg hard capsules SPC (L01EA03 nilotinib) Prescription only (POM)
Nintedanib 100 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Nintedanib 150 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Nintedanib Advanz Pharma 150 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Nintedanib Olpha 100 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Nintedanib Olpha 150 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Nintedanib Sandoz 100 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Nintedanib Sandoz 150 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Ofev 100 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Ofev 150 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Ofev 25 mg soft capsules SPC (L01EX09 nintedanib) Prescription only (POM)
Palbociclib 100 mg film-coated tablets SPC (L01EF01 palbociclib) Prescription only (POM)
Palbociclib 125 mg film-coated tablets SPC (L01EF01 palbociclib) Prescription only (POM)
Palbociclib 75 mg film-coated tablets (L01EF01 palbociclib) Prescription only (POM)
Pazopanib 200 mg film-coated tablets SPC (L01EX03 pazopanib) Prescription only (POM)
Pazopanib 400 mg film-coated tablets SPC (L01EX03 pazopanib) Prescription only (POM)
Pemazyre 4.5 mg tablets SPC (L01EX20 pemigatinib) Prescription only (POM)
Piqray 150 mg film-coated tablet SPC (L01EM03 alpelisib) Prescription only (POM)
Piqray 200 mg film-coated tablet SPC (L01EM03 alpelisib) Prescription only (POM)
Piqray 50 mg & 200 mg film-coated tablets SPC (L01EM03 alpelisib) Prescription only (POM)
Ponatinib Incyte 45 mg film-coated tablets SPC (L01EA05 ponatinib) Prescription only (POM)
Qinlock 50 mg tablets SPC (L01EX19 ripretinib) Prescription only (POM)
Rozlytrek 100 mg hard capsules SPC (L01EX14 entrectinib) Prescription only (POM)
Rozlytrek 200 mg hard capsules SPC (L01EX14 entrectinib) Prescription only (POM)
Ruxolitinib 10 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib 15 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib 20 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib 25 mg tablets SPC (L01EJ01 ruxolitinib) –
Ruxolitinib 5 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Advanz Pharma 10 mg tablets (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Advanz Pharma 15 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Advanz Pharma 5 mg tablets (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Torrent 10 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Torrent 15 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Torrent 20 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Ruxolitinib Torrent 5 mg tablets SPC (L01EJ01 ruxolitinib) Prescription only (POM)
Rydapt 25 mg soft capsules SPC (L01EX10 midostaurin) Prescription only (POM)
Sorafenib 200 mg film-coated tablets SPC (L01EX02 sorafenib) Prescription only (POM)
Sorafenib Sandoz 200 mg film-coated tablets SPC no longer supplied (L01EX02 sorafenib) –
Sorafenib Teva 200 mg film-coated tablets SPC (L01EX02 sorafenib) Prescription only (POM)
Sorafenib Torrent 200 mg film-coated tablets SPC (L01EX02 sorafenib) Prescription only (POM)
Sorafenib Zentiva 200 mg film-coated tablets SPC (L01EX02 sorafenib) Prescription only (POM)
Spexotras 0.05 mg/ml powder for oral solution (L01EE01 trametinib) Prescription only (POM)
Sprycel 10 mg / ml powder for oral suspension SPC (L01EA02 dasatinib) Prescription only (POM)
Sprycel 100 mg film-coated tablets SPC (L01EA02 dasatinib) Prescription only (POM)
Sprycel 140 mg film-coated tablets SPC (L01EA02 dasatinib) Prescription only (POM)
Sprycel 20 mg film-coated tablets SPC (L01EA02 dasatinib) Prescription only (POM)
Sprycel 50 mg film coated tablet SPC (L01EA02 dasatinib) Prescription only (POM)
Sprycel 80 mg film-coated tablets SPC (L01EA02 dasatinib) Prescription only (POM)
Stivarga 40 mg film-coated tablets SPC (L01EX05 regorafenib) Prescription only (POM)
Sunitinib 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib 37.5 mg hard capsules SPC no longer supplied (L01EX01 sunitinib) –
Sunitinib 50 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Accord 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Accord 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Accord 37.5 mg hard capsules SPC no longer supplied (L01EX01 sunitinib) –
Sunitinib Accord 50 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Bluepharma 12.5 mg, hard capsule SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Bluepharma 25 mg, hard capsule SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Bluepharma 37.5 mg hard capsule SPC not available (L01EX01 sunitinib) –
Sunitinib Bluepharma 50 mg, hard capsule SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Cipla 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Cipla 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Cipla 50 mg hard capsules (L01EX01 sunitinib) Prescription only (POM)
Sunitinib DR. Reddys 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib DR. Reddys 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Egis 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Egis 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Mylan 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Mylan 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Mylan 37.5 mg hard capsules SPC not available (L01EX01 sunitinib) –
Sunitinib Mylan 50 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Piramal 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Piramal 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Piramal 37.5 mg hard capsules SPC not available (L01EX01 sunitinib) –
Sunitinib Piramal 50 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Sandoz 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Stada 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Stada 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sunitinib Zentiva 12.5 mg hard capsules SPC no longer supplied (L01EX01 sunitinib) –
Sunitinib Zentiva 25 mg hard capsules SPC no longer supplied (L01EX01 sunitinib) –
Sunitinib Zentiva 37.5 mg hard capsules SPC not available (L01EX01 sunitinib) –
Sunitinib Zentiva 50 mg hard capsules SPC no longer supplied (L01EX01 sunitinib) –
Sutent 12.5 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sutent 25 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Sutent 50 mg hard capsules SPC (L01EX01 sunitinib) Prescription only (POM)
Tabrecta 200 mg film-coated tablets SPC (L01EX17 capmatinib) –

Sources

  • Patient leaflets and SPCs: the MHRA product information (products.mhra.gov.uk) and the European Medicines Agency (EMA)
  • Active substances, ATC codes and legal categories: the NHS Dictionary of Medicines and Devices (dm+d), NHS Business Services Authority
  • World Health Organization (WHO): ATC/DDD classification, group L01E

Contains public sector information licensed under the Open Government Licence v3.0.

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