L01EE Mitogen-activated protein kinase (MEK) inhibitors
ATC group of level 4 – chemical subgroup · in plain English: targeted cancer medicines (kinase inhibitors)
This site has the patient leaflet or the SPC of 10 medicines in this group and its subgroups.
- 10 prescription only (POM)
Place in the ATC classification
- L Antineoplastic and immunomodulating agents 1,791 medicines
- L01 Antineoplastic agents 1,025 medicines
- L01E Protein kinase inhibitors, antineoplastic and immunomodulating agents 353 medicines
-
L01EE Mitogen-activated protein kinase (MEK) inhibitors 10 medicines
- L01EE01 trametinib 3 medicines
- L01EE02 cobimetinib 1 medicine
- L01EE03 binimetinib 2 medicines
- L01EE04 selumetinib 4 medicines
-
L01EE Mitogen-activated protein kinase (MEK) inhibitors 10 medicines
- L01E Protein kinase inhibitors, antineoplastic and immunomodulating agents 353 medicines
- L01 Antineoplastic agents 1,025 medicines
Active substances in the group
- Binimetinib 2 medicines
- Cobimetinib 1 medicine
- Selumetinib 4 medicines
- Trametinib 3 medicines
Medicines in the group and its subgroups
| Medicine | Legal category |
|---|---|
| Cotellic 20 mg film-coated tablets SPC (L01EE02 cobimetinib) | Prescription only (POM) |
| Koselugo 10 mg hard capsule SPC (L01EE04 selumetinib) | Prescription only (POM) |
| Koselugo 25 mg hard capsules SPC (L01EE04 selumetinib) | Prescription only (POM) |
| Koselugo 5 mg granules in capsule for Opening (L01EE04 selumetinib) | Prescription only (POM) |
| Koselugo 7.5 mg granules in capsule for Opening SPC (L01EE04 selumetinib) | Prescription only (POM) |
| Mekinist 0.5 mg film-coated tablets SPC (L01EE01 trametinib) | Prescription only (POM) |
| Mekinist 2 mg film-coated tablets SPC (L01EE01 trametinib) | Prescription only (POM) |
| Mektovi 15 mg film-coated tablets SPC (L01EE03 binimetinib) | Prescription only (POM) |
| Mektovi 45 mg film-coated tablets (L01EE03 binimetinib) | Prescription only (POM) |
| Spexotras 0.05 mg/ml powder for oral solution (L01EE01 trametinib) | Prescription only (POM) |
Other groups of the same level
- L01EA BCR-ABL tyrosine kinase inhibitors 101 medicines
- L01EB Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors 40 medicines
- L01EC B-Raf serine-threonine kinase (BRAF) inhibitors 6 medicines
- L01ED Anaplastic lymphoma kinase (ALK) inhibitors 14 medicines
- L01EF Cyclin-dependent kinase (CDK) inhibitors 13 medicines
- L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors 27 medicines
- L01EH Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors 4 medicines
- L01EJ Janus-associated kinase (JAK) inhibitors 18 medicines
- L01EK Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors 12 medicines
- L01EL Bruton's tyrosine kinase (BTK) inhibitors 8 medicines
- L01EM Phosphatidylinositol-3-kinase (Pi3K) inhibitors 6 medicines
- L01EX Other protein kinase inhibitors 94 medicines
Other names of the ATC group
Sources
- Patient leaflets and SPCs: the MHRA product information (products.mhra.gov.uk) and the European Medicines Agency (EMA)
- Active substances, ATC codes and legal categories: the NHS Dictionary of Medicines and Devices (dm+d), NHS Business Services Authority
- World Health Organization (WHO): ATC/DDD classification, group L01EE
Contains public sector information licensed under the Open Government Licence v3.0.
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