Patient leaflet - Qinlock 50 mg tablets
1. What QINLOCK is and what it is used
QINLOCK is a cancer medicine containing the ac protein kinase inhibitor. Protein kinase inhibitor
n
for
tive substance ripretinib, a s are used to treat cancer by
Other medicines and
Tell your doctor or ph take any other medic
QINLOCK can affect t can affect the way QI
In particular, tell your
stopping the activity of certain proteins that are spread of cancer cells.
QINLOCK is used to treat adults with gastrointe (GIST), a rare type of cancer of the digestive sys and bowel, that has:
- spread to other parts of the body or cann
been treated with at least 3 previous canc
imatinib.
involved in the growth and
stinal stromal tumour tem including the stomach
ot be removed by surgery er medicines, including
medicines used
itraconazole, po
medicines used
clarithromycin,
medicines used
bictegravir, cab
medicines used
phenobarbital,
- medicines used
If you have any questions about how QINLOCK has been prescribed for you, please ask your d
2. What you need to know before you t
Do not take QINLOCK if you are allergic to ripre ingredients of this medicine (listed in section 6)
Warnings and precautions
works or why this medicine octor.
ake QINLOCK
tinib or any of the other .
medicines used
dabigatran etex
- medicines used
medicines used
repaglinide or m
medicines used
inflammation (s
- medicines used
- medicines used
Before taking QINLOCK, talk to your doctor or have a history of:
high blood pressure. Your doctor will mon
prior to and during treatment with QINLO medicine to treat high blood pressure, if n
heart conditions. Your doctor may perform
your heart functions prior to and during yo
liver or kidney problems.
pharmacist if you have or
itor your blood pressure CK and may give you a eeded.
additional tests to assess how ur treatment with QINLOCK.
tacrolimus)
medicines used
eltrombopag)
- medicines used
medicines used
midazolam)
herbal preparat
St. John’s Wort
QINLOCK with food a
When taking QINLOCK, talk to your doctor or p
you notice redness, pain, swelling, or blist
hands or soles of your feet. This is a skin p plantar erythrodysaesthesia syndrome (PP continue your treatment, change your dos until your condition improves (see section
you notice unexpected skin changes such
harmacist if:
ers on the palms of your roblem called palmar-ES). Your doctor may e or stop your treatment 4).
as a new wart, open sore
Grapefruit juice may grapefruit juice or ea with this medicine.
Contraception, pregn
Contraception
Both women of child contraception during
or reddish bump that bleeds or does not h colour of a mole. QINLOCK may increase t skin cancers (see section 4). Your doctor w starting treatment with QINLOCK and rout important that you check your skin regula
you have wounds from any recent surgery
expected. QINLOCK may affect the way wo
eal, or a change in size or he risk of some types of ill check your skin when inely during treatment. It is rly.
that aren’t healing as unds heal. Your doctor may
of treatment. If horm condoms) should be
Pregnancy
If you are pregnant, t baby, you should not treatment with QINL for advice before taki
decide to temporarily stop treatment with surgery and until your wound has healed will decide when to start QINLOCK again. I your doctor if you have any planned surge
QINLOCK a few days before after surgery. Your doctor t is important that you tell ries in the future.
hort of breath, notice protruding veins in your neck, g of the abdomen, ankles or lower legs while taking may be symptoms of heart failure (see section 4).
s become more sensitive to sunlight or other forms expose yourself to direct sunlight, sunlamps and
Do not get pregnant while you are being treat
a male patient with a partner who is either pre pregnant, you must use a barrier method (suc intercourse, during treatment and for at least treatment. This medicine may harm your unbo and your female partner becomes pregnant du
f ultraviolet radiation when taking this medicine. Yo otective clothing, and apply sun cream with high sun r when you are exposed to strong sunlight.
on for men and women about contraception
arm to your unborn baby. Do not become pregnant K. Use effective contraception during treatment and ter the final dose of QINLOCK if you are a female of
u
QINLOCK, tell your doctor right away.
Woman of childbearing potential will have to d treatment start with QINLOCK and during treat
Breastfeeding
Do not breast-feed your baby during treatmen at least 1 week after completing treatment, as
l or a male with a female partner of childbearing rmonal contraception, add a barrier contraception ee section on ‘Contraception, pregnancy, breastfeed
ents
icine to children and adolescents below 18 years of a en studied in this age group.
ing
ge
serious side effects in your baby. Tell your doc or planning to breast-feed.
Fertility
QINLOCK may affect fertility in men and wome before taking QINLOCK.
Driving and using machines
QINLOCK
armacist if you are taking, have recently taken or mi ines.
he way some medicines work. Also, some medicines NLOCK works.
doctor if you are taking any of the following medicin
ght
es:
QINLOCK does not directly affect your ability t feel unwell or very tired while being treated w drive or operate machinery until you feel safe
QINLOCK contains lactose
If you have been told by your doctor that you h sugars, contact your doctor before taking this
3. How to take QINLOCK
to treat fungal infections (such as ketoconazole, saconazole, voriconazole)
to treat bacterial infections (such as erythromycin, rifampicin)
to treat HIV (such as ritonavir, efavirenz, etravirine, otegravir, dolutegravir, raltegravir)
for epilepsy or fits (such as phenytoin, carbamazepi lamotrigine)
to treat irregular heartbeats (such as digoxin)
ne,
QINLOCK will be prescribed for you by a docto anticancer therapies.
Always take this medicine exactly as your doct your doctor or pharmacist if you are not sure.
The recommended daily dose is three 50 mg t Take the tablets at the same time each day wi
to prevent stroke or harmful blood clots (such as ilate)
to lower elevated cholesterol (such as rosuvastatin) to reduce blood glucose or to treat diabetes (such a etformin)
to treat severe bowel and rheumatic joint uch as sulfasalazine)
to treat cancer (such as paclitaxel or irinotecan) to prevent organ rejection (such as cyclosporine,
s
the tablets whole with a glass of water and do the tablets. Do not take any tablets that are br damaged due to unknown effects of taking tab If you have to take certain other medicines at t your doctor may change your dose to three 50 twice daily.
You will usually take QINLOCK as long as you ar suffering unacceptable side effects (see sectio
to treat low platelet counts in the blood (such as
to treat muscle spasms (such as tizanidine) to relieve anxiety before procedures (such as
ions used to treat depression and anxiety containing (Hypericum perforatum).
nd drink
may reduce your dose, or may decide to interr temporarily or permanently if necessary.
If you have kidney or severe liver problems While you are being treated with QINLOCK, yo kidney or liver function more closely.
If you take more QINLOCK than you should
If you have accidentally taken too many tablets attention.
change the amount of QINLOCK in your body. Drinki ting grapefruit is not recommended during treatmen
ancy, breast-feeding and fertility
bearing potential and men should use effective treatment and for at least 1 week after completion
ng
t If you forget to take QINLOCK
What to do if you forget to take this medicine, remember the dose that has been forgotten. If
8 hours or less (4 hours or less for 150 m
the time it should have been taken, take you remember. Then take the next dose
more than 8 hours after (more than 4 hou
doses) the time it should have been taken
onal contraception is used, a barrier method (such a added.
hink you may be pregnant or are planning to have a take this medicine, unless your doctor has decided t OCK is clearly necessary. Ask your doctor or pharmac ng this medicine.
s
hat
ist
Then take the next dose at the usual time. Do not take a double dose to make up a forgot
If you are sick when taking QINLOCK
If you are sick (vomiting) after taking this medi additional dose, but carry on as normal. Take y next day at the usual time and tell your doctor
ed with QINLOCK. If you are gnant or who could become h as condoms) during sexual 1 week after completion of rn baby. If you are a male ring your treatment with
4. Possible side
Like all medicines, t everybody gets the
Serious side effects Seek urgent medica
o pregnancy tests before ment.
t with QINLOCK and for this medicine may cause
serious side effects
Skin problems
PPES is a very develop:
rednes
or sole your doctor may co
tor if you are breast-feeding
n. Ask your doctor for advice
treatment until you
High blood pre
High blood pre medicine. If yo
headac
be sym your doctor may ch
o drive or use machines. If you ith QINLOCK you should not to do so.
ave an intolerance to some medicine.
condition improves.
Heart problem
Heart failure is If you feel:
- very tir these may be sympt
Talk to your doctor
r experienced in using
or has told you. Check with
ablets (150 mg) once daily. th or without food. Swallow
Skin cancer
Treatment wit such as ‘cutan your doctor if a new wart, op or a change in when starting (see section 2)
not chew, split, or crush oken, cracked, or otherwise let that are not whole. he same time as QINLOCK, mg tablets (150 mg)
e benefitting from it and not n 4); however, your doctor
Very common side
- feeling sick (na
- constipation
- diarrhoea
- being sick (vo
- joint pain
- headache
- shortness of b
- blood tests sh
upt or stop the treatment
ur doctor will monitor your
, seek urgent medical
by the liver
blood tests sh
digestion
- blood tests sh
- tiredness
- hair loss
- muscle ache o
- weight loss
- muscle spasm
depends on when you it is:
g twice per day doses) after the missed dose as soon as as usual.
rs for 150 mg twice per day , skip the missed dose.
- dry skin
- back pain
- cough
- swelling in han
- pain in hands
- itching
- non-cancerous
Common side effec
ten dose.
cine, do not take an
our next dose of tablets the you have been sick.
- sores in mouth
- belly (abdomi
peripheral ner
burning, stabb and co-coordi
skin reactions
characterised bumps or acne
If you have any further questions on the use of ask your doctor.
this medicine,
effects
his medicine can cause side effects, although not m.
l attention if you experience any of the following
(see section 2):
(called PPES)
common side effect when taking this medicine. If yo
s, pain, swelling, or blisters on the palms of your han s of your feet,
ntinue your treatment, change your dose or stop you
u
ds
r
r condition improves.
ssure
ssure is a very common side effect when taking this u develop:
he, feeling of lightheadedness, or dizziness, these m ptoms of high blood pressure,
ange your dose or stop your treatment until your
ay
s (heart failure)
a common side effect when taking this medicine.
ed, are short of breath, have swollen feet and/or an oms of heart problems.
or pharmacist if you experience:
kles,
h QINLOCK may result in certain types of skin cancer eous squamous cell carcinoma’ and ‘melanoma’. Tell you notice any skin changes during treatment includ en sore or reddish bump that bleeds or does not he size or colour of a mole. Your doctor will check your treatment with QINLOCK and routinely during treat .
ing
al,
skin ment
effects (may affect more than 1 in 10 people): usea)
miting)
reath
owing increased levels of bilirubin, a substance prod
uced
owing increased levels of lipase, an enzyme involved
owing decreased levels of phosphate
r pain
s
in
ds and lower legs
or feet
skin lesions
ts (may affect up to 1 in 10 people):
nal) pain
ve impairment (numbness and tingling in feet or han ing or shooting pain in affected areas, loss of balanc nation, and muscle weakness, especially in the feet) such as flaking and inflammation of the skin, rash by a flat, red area on the skin that is covered with sm
ds, e
all
abnormal liver test (possible liver dama
ge shown by blood test)
- depression
- underactive thyroid gland
- weakness
- chest pain
- rapid heart rate
Reporting of side effects
If you get any side effects, talk to your docto includes any possible side effects not listed i also report side effects directly via the Yellow Website: www.mhra.gov.uk/yellowcard or se the Google Play or Apple App Store. By repor provide more information on the safety of th
r or pharmacist. This n this leaflet. You can
Card Scheme at:
arch for MHRA Yellow Card in ting side effects, you can help is medicine.
5. How to store QINLOCK
Keep this medicine out of the sight and reach
Do not use this medicine after the expiry da carton and the bottle label after EXP. The ex of that month.
of children.
te which is stated on the piry date refers to the last day
This medicine does not require any special te
Store in the original package and keep the bo protect from light and moisture.
Do not use this medicine if you notice that th signs of tampering.
mperature storage conditions.
ttle tightly closed in order to e pack is damaged or shows
Do not throw away any medicines via wastew your pharmacist how to throw away medicin measures will help protect the environment.
6. Contents of the pack and other info
What QINLOCK contains
The active substance is ripretinib. Each t
ater or household waste. Ask es you no longer use. These rmation ablet contains 50 mg of ripretinib.
- The other ingredients are crospovidone acetate succinate, lactose monohydrate microcrystalline cellulose (E460), and co (see section 2 “QINLOCK contains lactos
What QINLOCK looks like and contents of th
QINLOCK tablets are white to off-white, oval i ‘DC1' on one side.
(E1202), hypromellose , magnesium stearate (E470b), lloidal hydrated silica (E551) e”).
e pack n shape, and debossed with
Each bottle is child-resistant and contains 30 The bottles are provided with aluminium foil/ evident seal. The desiccant is a moisture abso container to protect the tablets from moistur pouch in the bottle and do not eat it.
Not all pack sizes may be marketed.
Marketing Authorisation Holder
or 90 tablets and a desiccant. polyethylene (PE) tamper rbing material filled in a small e. Always keep the desiccant
Deciphera Pharmaceuticals (Netherlands) B.V Strawinskylaan 3051
1077ZX, Amsterdam
Netherlands
Manufacturer
Deciphera Pharmaceuticals (Netherlands) B.V Strawinskylaan 3051
1077ZX, Amsterdam
.
.
Netherlands
This leaflet was last revised in April 2026
QINLOCK® 50 mg
APR 2026 803652
QINLOCK® 50 mg
APR 2026 803652