Patient leaflet - Nefopam Hydrochloride 60 mg film-coated tablets
1. What Nefopam hydrochloride is and what it is used for
Nefopam hydrochloride belongs to a group of medicines called analgesics, commonly known as pain killers or pain relievers. The active substance, nefopam hydrochloride, interrupts the pain messages being sent to your brain, and it also acts in your brain to stop pain messages being felt. This means that Nefopam hydrochloride does not stop the pain from happening, but you will not be able to feel the pain as much.
Nefopam hydrochloride is used to relieve acute and chronic pain (for example pain after an operation, dental pain, joint or muscle pain, after an injury, or pain caused by cancer). Nefopam hydrochloride should not be used to treat the pain from a heart attack.
2. What you need to know before you take Nefopam hydrochloride
Do not take Nefopam hydrochloride tablets if:
Ÿ you are a child under 12 years old
Ÿ you have ever had an allergic reaction to
nefopam hydrochloride or any of the ingredients resulting in a skin rash, swelling of the face or difficulty in breathing (see section 6. Contents of the pack and other information)
Ÿ you are taking monoamine oxidase inhibitors
(MAOIs) to treat your depression
Ÿ you have, or have ever had, epilepsy (fits). Ÿ Your dose is less than 60mg.
Take special care with Nefopam hydrochloride
If the answer to any of the following is 'yes', you must tell your doctor – your doctor may decide to alter your treatment.
Ÿ Are you pregnant or breast feeding? Ÿ Do you have severe problems with your liver or
kidneys?
Ÿ Do you have, or have you had in the past
difficulty passing urine?
Ÿ Are you taking other medicines?
Ÿ Have you previously been diagnosed with
glaucoma (increased pressure in the eye)?
Use of Nefopam may lead to dependence and abuse. If you have concerns that you may become dependent on Nefopam, it is important that you consult your doctor.
Package leaflet: Information for the patient
Nefopam hydrochloride 60 mg film-coated tablets
(nefopam hydrochloride)
Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without prescription and medicines listed below:
Ÿ Monoamine oxidase inhibitors (known as
MAOIs) for depression. You must tell your doctor if you are taking this medicine. Ÿ Tricyclic antidepressants for depression Ÿ Anticholinergics
Ÿ Sympathomimetics
Tell your doctor or dentist if you are taking any of these medicines.
Pregnancy and breast-feeding
Nefopam hydrochloride should not be taken during pregnancy or while breast-feeding.
Ask your doctor or pharmacist for advice before taking any medicine. Please contact your doctor if you become pregnant during your treatment.
Driving and using machines
Nefopam hydrochloride can cause drowsiness. Do not drive or operate heavy machinery unless you know how Nefopam hydrochloride affects you.
3. How to take Nefopam hydrochloride
Dosage for adults:
Always take Nefopam hydrochloride exactly as your doctor has told you.
The usual initial dose is one tablet taken three times a day. Your doctor may increase this dose by adding another strength (i.e. one tablet of Nefopam 30mg) up to a maximum of 90mg taken three times a day according to your needs.
Ask your doctor or pharmacist if:
Ÿ you are not sure how many tablets to take or
when to take them
Ÿ you think the effect is too strong or too weak
Swallow your tablets with water.
Do not break this tablet as it cannot be divided into two equal halves.
Dosage for children:
Over 12 years - as per adults (see above). Under 12 years - Nefopam hydrochloride tablets should not be taken by children under 12.
Dosage for older patients :
In older patients the doctor may reduce the dose by prescribing Nefopam 30mg tablets.
Dosage for patients with kidney and/or liver problems: Your doctor may adjust the dose of Nefopam hydrochloride depending upon your condition.
If you take more Nefopam hydrochloride than you should
If you accidentally take more tablets than your prescribed dose, tell your doctor or pharmacist immediately and if necessary contact your nearest hospital casualty department. Remember to take the pack and any remaining medicines with you.
If you forget to take Nefopam hydrochloride
If you forget to take Nefopam hydrochloride, take it as soon as you remember. Do not take more than one dose at the same time to make up for the forgotten dose.
If you stop taking Nefopam hydrochloride
Do not stop taking Nefopam hydrochloride without first checking with your doctor.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Please stop taking this medicine and contact your doctor as soon as possible if you experience the following rare reactions:
Ÿ swelling of the skin and soft tissue around the eyes, nose and throat (angioedema), or allergic reactions (anaphylaxis).
Side-effects which may occur most frequently include:
Ÿ feeling sick
Ÿ feeling light-headed, dizzy or nervous, or fainting Ÿ a decrease in blood pressure
Ÿ numbness or tingling in the extremities Ÿ a dry mouth
Ÿ having difficulty passing urine
Ÿ convulsions, tremor
Ÿ confusion
Ÿ hallucinations (seeing things that aren't there) Ÿ awareness of your heartbeat (palpitations)
Other side-effects which may occur less frequently include:
Ÿ being sick
Ÿ abdominal pain or diarrhoea
Ÿ blurred vision
Ÿ drowsiness
Ÿ sweating
Ÿ trouble sleeping
Ÿ headaches
Ÿ fast heartbeat (tachycardia)
Ÿ coma
Rare (may affect up to 1 in 1,000 people): Ÿ becoming dependent on Nefopam (drug dependence).
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.
You can also report side effects directly via Yellow Card Scheme, Website:
www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
5. How to store Nefopam hydrochloride
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton or blister after EXP. The expiry date refers to the last day of that month.
Do not store above 25 °C.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Nefopam hydrochloride contains
The active substance is nefopam hydrochloride. Each film-coated tablet contains 60 mg nefopam hydrochloride.
The other ingredients are:
Tablet core: Microcrystalline cellulose, calcium hydrogen phosphate dihydrate, pregelatinised maize starch, silica, colloidal anhydrous, hydrogenated castor oil and magnesium stearate. Tablet coat: Hypromellose and titanium dioxide.
Size 150(L) x 350(W) mm Front
Size 150(L) x 350(W) mm Back
What Nefopam hydrochloride looks like and contents of the pack
White to off-white, circular, biconvex, film coated tablets, debossed with 'NT1' on one face and plain on other face.
The tablets are packaged in blister packs of 30, 60 and 90 film-coated tablets.
Not all pack sizes may be marketed.
Marketing Authorisation Holder and Manufacturer
Brown & Burk UK Ltd
Micro House
5 Marryat Close
Hounslow
TW4 5DQ
United Kingdom
This leaflet was last revised in 3/2026.
If you would like a leaflet with larger text, please contact +44 (0)203 384 7188.