Patient leaflet - Coryen 27.5 micrograms/actuation, nasal spray suspension
1. What Coryen is and what it is used for
Coryen contains fluticasone furoate which belongs to a group of medicines called glucocorticoids. Coryen works by reducing inflammation caused by allergy (rhinitis) and so helps to reduce symptoms of allergy.
Coryen nasal spray is used to treat symptoms of allergic rhinitis including blocked, runny or itchy nose, sneezing and watery, itchy or red eyes, in adults and children aged 6 years and over.
Allergy symptoms can occur at specific times of the year and be caused by allergy to pollen from grass or trees (hay fever), or they can occur all year round and be caused by allergy to animals, dust mites or moulds to name some of the most common.
2. What you need to know before you use Coryen
Do not use Coryen if you are allergic to fluticasone furoate or any of the other ingredients of this medicine (listed in section 6).
Warnings and precautions
Taking Coryen
- may, when taken for a long time, cause children to grow more slowly. The doctor will check your child’s height regularly, and make sure he or she is taking the lowest possible effective dose.
- may cause eye conditions such as glaucoma (increase in pressure in the eye) or cataract (clouding of the lens of the eye). Tell your doctor if you had these conditions in the past, or if you notice blurred vision or other visual disturbances while you are taking Coryen.
Children and adolescents
Do not use in children under 6 years old.
Other medicines and Coryen
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines, including medicines obtained without a prescription.
It is especially important to tell your doctor if you are taking, or have recently taken any of the following medicines:
- steroid tablets or injected steroids
- steroid creams
- medicines for asthma
- ritonavir or cobicistat, used to treat HIV
- ketoconazole, used to treat fungal infections
Your doctor will assess whether you should take Coryen together with these medicines. Your doctor may wish to monitor you carefully if you are using any of these medicines as they may increase the side effects of Coryen.
Coryen should not be used at the same time with other nasal sprays containing steroids.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Do not use Coryen if you are pregnant, or planning to become pregnant, unless your doctor or pharmacist tells you to.
Do not use Coryen if you are breast-feeding unless your doctor or pharmacist tells you to.
Driving and using machines
Coryen is unlikely to affect your ability to drive and use machines.
Coryen contains benzalkonium chloride
This medicine contains 8.25 micrograms of benzalkonium chloride in each actuation, which is equivalent to 150 microgram per gram.
Benzalkonium chloride may cause irritation or swelling inside of the nose, especially if used for a long time. Tell your doctor or pharmacist if you feel discomfort when using the spray.
3. How to use Coryen
Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Don’t exceed the recommended dose.
When to use Coryen
- Use once a day
- Use at the same time each day
This will treat your symptoms throughout the day and night.
How long Coryen takes to work
Some people will not feel the full effects until several days after first using Coryen.
However, it is usually effective within 8 to 24 hours of use.
How much to use
Adults and children 12 years and over
- The usual starting dose is 2 sprays in each nostril once every day.
- Once your symptoms get less, you may be able to decrease your dose to 1 spray in each nostril, once every day.
Children 6 to 11 years
- The usual starting dose is 1 spray in each nostril once a day.
- If your symptoms are very bad your doctor may increase the dose to 2 sprays in each nostril once every day until the symptoms are under control. It may then be possible to reduce the dose to 1 spray in each nostril once every day.
Package leaflet: Information for the user
Coryen® 27.5 micrograms/actuation, nasal spray suspension fluticasone furoate
Read all of this leaflet carefully before you start using this medicine because it contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
Continued overleaf Preparing your nasal spray for use
Coryen has practically no taste or smell. It is sprayed into the nose as a fine mist.
Be careful not to get any spray into your eyes. If you do, rinse your eyes with water.
Coryen has a dust cap that protects the nozzle and keeps it clean. Remember to take the cap off before using the spray and to replace it after use.
If you are using the spray for the first time, you need to “prime” (prepare) the bottle by pumping the spray six times until you see a fine mist:
- 1. Gently shake the bottle and remove the dust cap.
- 2. Put your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Do not pierce the nasal applicator.
- 3. Point the nozzle away from you and then press down with your fingers to pump the spray six times until you see a fine mist.
If you have not used the spray for seven days or more, you need to “re-prime” the bottle by pumping the spray at least six times.
Using the nasal spray
- 1. Shake the bottle and remove the dust cap.
- 2. Gently blow your nose.
- 3. Close one nostril with your finger and put the nozzle in the other nostril. Slightly tilt your head forward and keep the bottle upright.
- 4. Breathe in slowly and gently through your nose while pressing the nozzle down ONCE with the fingers of your other hand.
- 5. Breathe out through your mouth.
- 6. Repeat step 4 and 5 to inhale a second spray in the same nostril, if applicable.
- 7. Repeat step 3 through 6 for the other nostril.
- 8. After each use, wipe the nozzle and inside of the dust cap carefully with a clean and dry tissue and replace the dust cap.
Cleaning the nasal spray
It is important to clean your nasal spray regularly; otherwise, it may not work properly.
- Do not try to unblock the nasal applicator by inserting a pin or other sharp object, because this will damage the applicator and it will no longer dispense the correct dose of medicine.
If you use more Coryen than you should
Tell your doctor or pharmacist.
If you forget to use Coryen
If you miss a dose, take it when you remember.
If it is nearly the time for your next dose, wait until then. Do not take a double dose to make up for a forgotten dose.
If you have any further questions on the use of this medicine, or if you have any discomfort using the nasal spray ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Allergic reactions: get a doctor’s help straight away
Allergic reactions to Coryen are rare and less than 1 person in 1,000 gets them. In a small number of people, allergic reactions can develop into a more serious, even life-threatening problem if not treated. Symptoms include:
- becoming very wheezy, coughing or having difficulty with breathing
- suddenly feeling weak or light-headed (which may lead to collapse or loss of consciousness)
- swelling of the face
- skin rashes or redness.
In many cases, these symptoms will be signs of less serious side effects. But you must be aware that they are potentially serious — so, if you notice any of these symptoms: Contact a doctor as soon as possible.
Very common side effects (may affect more than 1 in 10 people)
- Nosebleeds (generally minor), particularly if you use Coryen for more than 6 weeks continuously.
Common side effects (may affect up to 1 in 10 people)
- Nasal ulceration – which may cause irritation or discomfort in your nose. You may also get streaks of blood when you blow your nose.
- Headache.
Shortness of breath
Uncommon side effects (may affect up to 1 in 100 people)
- Pain, burning, irritation, soreness or dryness in the inside of the nose.
Very rare side effects (may affect up to 1 in 10,000 people)
- Small holes (perforations) in the ridge inside the nose that separates the nostrils.
Not known (frequency cannot be estimated from the available data)
- Slowing of growth in children.
- Blurred vision or temporary changes to vision after long term use.
- Chest tightness causing difficulty in breathing.
- Voice disorder, voice loss.
- Taste disorder, taste loss, smell loss.
Nasal corticosteroids can affect the normal production of hormones in your body, particularly if you use high doses for a long time. In children this side effect can cause them to grow more slowly than others.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
5. How to store Coryen
Keep this medicine out of the sight and reach of children.
Always keep the dust cap on.
Do not use this medicine after the expiry date, which is stated on the label and carton after EXP. The expiry date refers to the last day of that month.
The bottle should be used within 3 months after first opening.
Do not refrigerate or freeze.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Coryen contains
- The active substance is fluticasone furoate. Each spray delivers 27.5 micrograms of fluticasone furoate.
- The other ingredients are glucose anhydrous, microcrystalline cellulose (E460) and carmellose sodium (E466), polysorbate 80 (E433), benzalkonium chloride, disodium edetate, purified water (see section 2).
What Coryen looks like and contents of the pack
Coryen is a white suspension contained in an amber glass bottle, fitted with a pump and a dust cap and is available in packs containing 60 or 120 sprays.
Not all pack sizes may be marketed.
Marketing Authorisation Holder
Alissa Healthcare Research Ltd
Unit 5, Fulcrum 1, Solent Way,
Whiteley, Fareham, Hampshire PO15 7FE, United Kingdom
Manufacturer
Basic Pharma Manufacturing B.V.
Burgemeester Lemmensstraat 352
6163 JT Geleen
The Netherlands
This leaflet was last revised in January 2025.
| Fluticasone Furoate Nasal Spray | |
| P00003/01 V8 08/01/2025 | |
| Calibri 8.5pt |