Ciprofloxacin 500mg Film-coated Tablets (Ciprofloxacin Hydrochloride) – patient leaflet, side effects, dosage

1. What Ciprofloxacin tablets are and what they are used for

These tablets contain the active substance ciprofloxacin. They belong to a group of antibiotic medicines called fluoroquinolones which work by killing bacteria that cause infections. It only works with specific strains of bacteria. Adults

Ciprofloxacin is used in adults to treat the following bacterial infections:

• Respiratory tract infections
• Long lasting or recurring ear or sinus infections
• Urinary tract infections
• Genital tract infections in men and women
• Gastro-intestinal tract infections and Intra-abdominal infections
• Skin and soft tissue infections
• Bone and joint infections
• To prevent infections due to the bacterium Neisseria meningitidis
• Anthrax inhalation exposure

Ciprofloxacin may be used in patients with low white blood cell counts (neutropenia) who have a fever that is suspected to be due to a bacterial infection.

If you have a severe infection or one that is caused by more than one type of bacterium, you may be given additional antibiotic treatment in addition to Ciprofloxacin tablets.

Children and adolescents

Ciprofloxacin is only used in children and adolescents under specialist medical supervision. It is used to treat the following bacterial infections:

• Lung and bronchial infections in children and adolescents suffering from cystic fibrosis
• Complicated urinary tract infections, including infections that have reached the kidneys (pyelonephritis)
• Anthrax inhalation exposure

Ciprofloxacin may also be used to treat other severe infections in children and adolescents when considered necessary by your doctor.

2. What you need to know before you take Ciprofloxacin tablets

Do not take Ciprofloxacin tablets if you:

• have previously had an allergic reaction to ciprofloxacin, any other quinolone antibiotic or any ingredient of this medicine (listed in section 6). If you are unsure about this, do not take this medicine before asking your doctor.
• are already taking a medicine called tizanidine (see “Other medicines and Ciprofloxacin tablets”)

Warnings and Precautions

Talk to your doctor or pharmacist before taking Ciprofloxacin tablets You should not take fluoroquinolone/quinolone antibacterial medicines, including Ciprofloxacin tablets, if you have experienced any serious adverse reaction in the past when taking a quinolone or fluoroquinolone. In this situation, you should inform your doctor as soon as possible. Talk to your doctor or pharmacist before taking these tablets if you:

• have ever had kidney problems because your treatment may need to be adjusted.
• have or have had problems with your liver. Your doctor may wish to check for any changes in its function.
• have myasthenia gravis (a type of muscle weakness) because symptoms can be exacerbated.
• have been diagnosed with an enlargement or “bulge” of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm).
• have experienced a previous episode of aortic dissection (a tear in the aorta wall).
• have been diagnosed with leaking heart valves (heart valve regurgitation).
• are diabetic because you may experience a risk of hypoglycaemia with ciprofloxacin.

• have a family history of aortic aneurysm or aortic dissection or congenital heart valve disease, or other risk factors or predisposing conditions (e.g. connective tissue disorders such as Marfan syndrome, or Ehlers-Danlos syndrome, Turner syndrome, Sjögren’s syndrome [an inflammatory autoimmune disease] or vascular disorders such as Takayasu arteritis, giant cell arteritis, Behcet’s disease, high blood pressure, or known atherosclerosis, rheumatoid arthritis [a disease of the joints] or endocarditis [an infection of the heart]).

  • have heart problems. Extra care should be taken if any of the following apply to you:

    • You were born with or have family history of a prolonged QT interval (seen on ECG, electrical recording of the heart)
    • You have salt imbalance in the blood (especially low levels of potassium or magnesium)
    • You have a very slow heart rhythm (called ‘bradycardia’)
    • You have a weak heart (heart failure)
    • You have a history of heart attack (myocardial infarction)
    • You are female or elderly, as you may be more sensitive to heart rhythm changes.
    • You are taking other medicines that result in abnormal ECG changes (see ‘Other medicines and Ciprofloxacin tablets’).
  • have previously had “fits”, suffer from epilepsy or other conditions of the nervous system.
  • have had tendon problems after taking quinolone antibiotics in the past.
  • have a family history of, or know that you have, G6PD deficiency. This condition may cause anaemia and yellowing of the skin (jaundice) when taken with this medicine.

If you feel sudden, severe pain in your abdomen, chest or back, which can be symptoms of aortic aneurysm and dissection go immediately to an emergency room.

Your risk may be increased if you are being treated with systemic corticosteroids.

If you start experiencing a rapid onset of shortness of breath, especially when you lie down flat in your bed, or you notice swelling of your ankles, feet or abdomen, or a new onset of heart palpitations (sensation of rapid or irregular heartbeat), you should inform a doctor immediately.

Where there is severe infection that cannot be treated by other antibiotics, ciprofloxacin may be given if tests can show the risk is justified For the treatment of some genital tract infections, your doctor can prescribe another antibiotic in addition to ciprofloxacin. If there is no improvement in symptoms after 3 days of treatment, please consult your doctor. While taking Ciprofloxacin tablets

Tell your doctor immediately, if any of the following occurs while taking Ciprofloxacin tablets. Your doctor will decide whether treatment with Ciprofloxacin tablets needs to be stopped.

Remember these important points while taking these tablets:

• Severe, sudden allergic reaction (an anaphylactic reaction/shock, angio-oedema). Even with the first dose, there is a small chance that you may experience a severe allergic reaction with the following symptoms: tightness in the chest, feeling dizzy, sick or faint, or experiencing dizziness when standing up. If this happens, stop taking Ciprofloxacin tablets and contact your doctor immediately.
• Prolonged, disabling and potentially irreversible serious side effects. Fluoroquinolone/quinolone antibacterial medicines, including Ciprofloxacin tablets, have been associated with rare but serious side effects, some of them being long lasting (continuing for months or years), disabling or potentially irreversible. This includes tendon, muscle and joint pain of the upper and lower limbs, difficulty in walking, abnormal sensations such as pins and needles, tingling, tickling, numbness or burning (paraesthesia), sensory disorders including impairment of vision, taste and smell, and hearing, mental health effects which may include, but are not necessarily limited to, anxiety, panic attacks, confusion, or depression memory impairment, severe fatigue, and severe sleep disorders. There are no medicines that have been established as being effective treatments for the symptoms of long lasting or disabling side effects associated with fluoroquinolones. If you experience any of these side effects after taking Ciprofloxacin tablets, then do not take any further doses and contact your doctor immediately. You and your doctor will decide on whether to continue treatment, considering alternative options.
• You may experience psychiatric reactions when taking Ciprofloxacin, including when taking it for the first time. If you suffer from depression or psychosis, your symptoms may become worse under treatment with Ciprofloxacin. In rare cases, depression or psychosis can progress to thoughts of suicide or suicide attempts. If this happens, stop taking Ciprofloxacin and contact your doctor immediately. You may not notice some changes in your mood and behaviour so it is very important to tell your friends and family that you are taking Ciprofloxacin, and that there may be rare psychiatric side effects. Others may notice changes and help you quickly identify any symptoms that you need to talk to your doctor about.
• This medicine may make your skin more sensitive to sunlight or UV light. Avoid exposure to strong sunlight and do not use a sun-bed or other means of UV exposure.
• If you have to provide a blood or urine sample tell the doctor or laboratory staff that you are taking Ciprofloxacin tablets as the results may be affected.

• Drink plenty of liquid whilst taking these tablets (unless you have a problem with your heart or kidneys). Ciprofloxacin may cause a problem with your kidneys which causes tiny crystals to form in the urine. These crystals cannot be seen by the naked eye. Drinking plenty of liquid can help prevent this occurring. Tell your doctor if you experience pain or discomfort when passing urine whilst you are taking this medicine.

  • If you feel depressed, anxious or confused whilst taking this medicine. If these progress to you actually or wanting to physically harm yourself stop taking this medicine immediately and talk to your doctor.
  • Quinolone antibiotics may cause an increase of your blood sugar levels above normal levels (hyperglycaemia), or lowering of your blood sugar levels below normal levels, potentially leading to loss of consciousness (hypoglycaemic coma) in severe cases (see section 4). This is important for people who have diabetes. If you suffer from diabetes, your blood sugar should be carefully monitored.
  • You may develop severe and persistent diarrhoea, which may contain blood and mucus, whilst you are taking antibiotics, including Ciprofloxacin tablets, or even several weeks after you have stopped taking these tablets. You may be suffering from the condition pseudomembranous colitis. Stop taking Ciprofloxacin tablets immediately, as this can be life-threatening. Do not take medicines that stop or slow down bowel movements and contact your doctor.
  • If your eyesight becomes impaired or if your eyes seem to be otherwise affected, consult an eye specialist immediately.
  • Ciprofloxacin may cause liver damage. If you notice any symptoms such as loss of appetite, jaundice (yellowing of the skin) or whites of the eyes, weight loss, dark urine, itchy skin or a tender abdomen, treatment with this medicine may need to be stopped.
  • Ciprofloxacin may cause a reduction in the number of white blood cells and your resistance to infection may be decreased. If you experience an infection with symptoms such as fever and serious deterioration of your general condition, or fever with local infection symptoms such as sore throat/pharynx/mouth or urinary problems, this medicine may cause a decrease in your resistance to infection. You should see your doctor immediately. A blood test will be taken to check for possible reduction in white blood cells (agranulocytosis).
  • Pain and swelling in the joints and inflammation or rupture of tendons may occur rarely. Your risk is increased if you are elderly (above 60 years of age), have received an organ transplant, have kidney problems or if you are being treated with corticosteroids. Inflammation and ruptures of tendons may occur within the first 48 hours of treatment and even up to several months after stopping of Ciprofloxacin tablets therapy. At the first sign of pain or inflammation of a tendon (for example in your ankle, wrist, elbow, shoulder or knee), stop taking Ciprofloxacin tablets, contact your doctor and rest the painful area. Avoid any unnecessary exercise as this might increase the risk of a tendon rupture.
  • If you feel sudden, severe pain in your abdomen, chest or back, which can be symptoms of aortic aneurysm and dissection, go immediately to an emergency room. Your risk may be increased if you are being treated with systemic corticosteroids.
  • If you start experiencing a rapid onset of shortness of breath, especially when you lie down flat in your bed, or you notice swelling of your ankles, feet or abdomen, or a new onset of heart palpitations (sensation of rapid or irregular heartbeat), you should inform a doctor immediately.
  • If you suffer from epilepsy or other neurological conditions such as cerebral ischemia or stroke, you may experience side effects associated with the central nervous system. If seizure happens, stop taking Ciprofloxacin tablets and contact your doctor immediately.
  • You may rarely experience symptoms of nerve damage (neuropathy) such as pain, burning, tingling, numbness and/or weakness especially in the feet and legs or hands and arms. If this happens, stop taking Ciprofloxacin tablets and inform your doctor immediately in order to prevent the development of potentially irreversible condition.
  • If you suffer from kidney problems, tell the doctor because your dose may need to be adjusted.

Children and adolescents

These tablets must not be taken by children under 18 years of age unless considered essential by a doctor. This medicine may cause pain and swelling in the developing joints of these patients. The tablets must never be taken by children aged under 5 years.

Other medicines and Ciprofloxacin tablets

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Do not take Ciprofloxacin together with tizanidine, because this may cause side effects such as low blood pressure and sleepiness.

Certain medicines are known to affect the action of Ciprofloxacin tablets and are best avoided whilst taking it. Ask your doctor for advice if you wish to take antacids for indigestion or any other preparations or supplements containing aluminium, calcium, magnesium or iron whilst taking Ciprofloxacin tablets. Your doctor may want you to stop taking them whilst you are taking this medicine.

If these preparations are essential, they must not be taken within four hours of taking this medicine.

The following medicines are known to interact with Ciprofloxacin tablets in your body. Taking Ciprofloxacin tablets together with these medicines can influence the therapeutic effect of those medicines. It can also increase the probability of experiencing side effects.

Tell your doctor if you are taking:

• vitamin K antagonists (e.g. warfarin, acenocoumarol, phenprocoumon or fluindione) or other oral anti-coagulants (to thin the blood)
• probenecid (for gout)
• methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis)
• theophylline (for breathing problems)
• tizanidine (for muscle spasticity in multiple sclerosis)
• olanzapine (an antipsychotic)
• clozapine (an antipsychotic)
• ropinirole (for Parkinson’s disease)

P3198T

Back side 330mm

P3198T

Process Black

• phenytoin (for epilepsy)
• metoclopramide (for nausea and vomiting)
• cyclosporin (for skin conditions, rheumatoid arthritis and in organ transplantation)
• other medicines that can alter your heart rhythm: medicines that belong to the group of anti-arrhythmics (e.g. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, some antimicrobials (that belong to the group of macrolides), some antipsychotics Ciprofloxacin tablets may increase the levels of the following medicines in your blood:
• pentoxifylline (for circulatory disorders)
• caffeine
• duloxetine (for depression, diabetic nerve damage or incontinence)
• lidocaine (for heart conditions or anaesthetic use)
• sildenafil (e.g. for erectile dysfunction)
• agomelatine (for depression)
• zolpidem (for sleep disorders)

Some medicines reduce the effect of Ciprofloxacin tablets. Tell your doctor if you take or wish to take:

• antacids
• omeprazole
• mineral supplements
• sucralfate
• a polymeric phosphate binder (e.g. sevelamer or lanthanum carbonate)
• medicines or supplements containing calcium, magnesium, aluminium or iron

If these preparations are essential, take Ciprofloxacin tablets about two hours before or no sooner than four hours after them.

Taking Ciprofloxacin tablets with food and drink

If you take these tablets on an empty stomach, do not eat or drink any dairy products (such as milk or yoghurt) or drinks with added calcium when you take the tablets, as they may affect the absorption of this medicine. If you take your tablets with meals, you can eat dairy products as usual.

Be aware that these tablets can increase the amount of caffeine in your blood so take care when consuming any drink that contains caffeine. Pregnancy and breastfeeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Ciprofloxacin tablets is not recommended for use in pregnancy. Ciprofloxacin is excreted in breast milk and can be harmful to your child. If you have already informed your doctor, follow his/her instructions carefully. Ask your doctor or pharmacist for advice before taking any medicine. Driving and using machines

Ciprofloxacin tablets may make you feel less alert, particularly when taken with alcohol. Some neurological adverse events can occur. Therefore, make sure you know how you react to Ciprofloxacin tablets before you drive or operate machinery. If in doubt, consult your doctor.

This product contains lactose

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking these tablets.

3. How to take Ciprofloxacin tablets

Your doctor will explain to you exactly how many Ciprofloxacin tablets you will have to take as well as how often and for how long. This will depend on the type of infection you have and how bad it is. Treatment usually lasts from 5 to 21 days but may take longer for severe infections. Some types of infection may need other antibiotic treatments in addition to Ciprofloxacin. Patients with reduced kidney function may need a lower dose and may be monitored more closely.

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

• Swallow the tablets whole with plenty of fluid. Do not chew the tablets because they do not taste nice.
• Try to take the tablets at around the same time every day.
• You can take the tablets at mealtimes or between meals.
• Any calcium you eat as part of a meal will not have a serious affect. If taken on an empty stomach do not take this medicine with dairy products, such as milk or yoghurt, or with fortified fruit juices (e.g. calcium- fortified orange juice).
• Remember to drink plenty of fluids while you are taking Ciprofloxacin tablets.

If you have the impression that the effect of Ciprofloxacin tablets is too strong or too weak talk to your doctor or pharmacist.

If you take more Ciprofloxacin tablets than you should

If you may have taken more Ciprofloxacin tablets than you should, talk to a doctor or pharmacist immediately. If possible, take your tablets or the box with you to show the doctor.

If you forget to take Ciprofloxacin tablets

Do not take a double dose to make up for forgotten dose.

Take your normal dose as soon as possible and then continue as prescribed. However, if it is almost time for your next dose, skip the missed dose and continue as usual, making sure that you complete your course of treatment. If you stop taking Ciprofloxacin tablets

It is important that you finish the course of treatment even if you begin to feel better after a few days. If you stop taking this medicine too soon, your infection may not be completely cured and the symptoms of the infection may return or get worse. You might also develop resistance to the antibiotic.

4. Possible Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following section contains the most serious side effects that you can recognize yourself:

Stop taking Ciprofloxacin tablets and contact your doctor immediately in order to consider another antibiotic treatment if you notice any of the following serious side effects:

Rare (may affect up to 1 in 1,000 people)

• allergic reaction, swelling (oedema), or rapid swelling of the skin and mucous membranes (angio-oedema) (see Section 2: Warnings and precautions)
• inflammation of the bowel (colitis) linked to antibiotic use (can be fatal in very rare cases) (see Section 2: Warnings and precautions)
• liver disorders, jaundice (cholestatic icterus), or hepatitis
• decreased blood sugar (hypoglycaemia) (see Section 2: Warnings and precautions)

Very rare (may affect up to 1 in 10,000 people)

• severe, sudden allergic reaction with symptoms such as tightness in the chest, feeling dizzy, sick or faint, or experience dizziness when standing up (anaphylactic reaction/shock which can be fatal - serum sickness) (see Section 2: Warnings and precautions)
• small, pin-point bleeding under the skin (petechiae); various skin eruptions or rashes (for example, the potentially fatal Stevens-Johnson syndrome or toxic epidermal necrolysis)
• inflammation of the wall of the blood vessels (vasculitis)
• inflammation of pancreas which includes symptoms such as severe upper stomach pain, often with nausea and vomiting (pancreatitis)
• muscle pain and/or weakness, inflammation of the tendons which could lead to rupture of the tendon, particularly affecting the large tendon at the back of the ankle (Achilles tendon) (see Section 2: Warnings and precautions)
• a serious life-threatening skin rash, usually in the form of blisters or ulcers in the mouth, throat, nose, eyes and other mucous membranes such as genitals which may progress to widespread blistering or peeling of the skin (Stevens-Johnson syndrome, toxic epidermal necrolysis). Not known (frequency cannot be estimated from the available data)
• abnormal fast heart rhythm, life-threatening irregular heart rhythm, alteration of the heart rhythm (called ‘prolongation of QT interval`, seen on ECG, electrical activity of the heart)
• unusual feelings of pain, burning tingling, numbness or muscle weakness in the extremities (neuropathy) (see Section 2: Warnings and precautions)
• loss of consciousness due to severe decrease in blood sugar levels (hypoglycaemic coma). See section 2.
• a drug reaction that causes rash, fever, inflammation of internal organs, hematologic abnormalities and systemic illness (DRESS Drug Reaction with Eosinophilia and Systemic Symptoms, AGEP Acute Generalised Exanthematous Pustulosis).

Other side effects which have been observed during treatment with Ciprofloxacin tablets are listed below by how likely they are: Common (may affect up to 1 in 10 people)

• nausea, diarrhoea
• joint pain and joint inflammation in children

Uncommon (may affect up to 1 in 100 people)

• joint pain in adults
• fungal superinfections
• a high concentration of eosinophils, a type of white blood cell
• decreased appetite
• hyperactivity or agitation
• headache, dizziness, sleeping problems, or taste disorders
• vomiting, abdominal pain, digestive problems such as stomach upset (indigestion/heartburn), or wind
• increased amounts of certain substances in the blood (transaminases and/or bilirubin)
• rash, itching, or hives
• poor kidney function
• pains in your muscles and bones, feeling unwell (asthenia), or fever
• increase in blood alkaline phosphatase (a certain substance in the blood) Rare (may affect up to 1 in 1,000 people)
• cases of long lasting (up to months or years) or permanent adverse drug reactions, have been associated with administration of quinolone and fluoroquinolone antibiotics, in some cases irrespective of pre-existing risk factors. These may include tendon inflammations, tendon rupture, joint pain, pain in the limbs, difficulty in walking, abnormal sensations such as pins and needles, tingling, pricking, burning, numbness or pain (neuropathy), fatigue, memory and concentration impairment, mental health effects (which may include sleep disorders, anxiety, panic attacks, confusion, or depression and suicidal ideation), as well as impairment of hearing, vision, and taste and smell. There are no medicines that have been established as being effective treatments for the symptoms of long lasting or disabling side effects associated with fluoroquinolones.
• muscle pain, inflammation of the joints, increased muscle tone and cramping
• changes to the blood count (leukopenia, leukocytosis, neutropenia, anaemia), increased or decreased amounts of a blood clotting factor (thrombocytes)
• increased blood sugar (hyperglycaemia)

• confusion, disorientation, anxiety reactions, strange dreams, depression (potentially leading to thoughts of suicide, suicide attempts, or completed suicide) (see Section 2: Warnings and precautions), or hallucinations, pins and needles, unusual sensitivity to stimuli of the senses, decreased skin sensitivity, tremors, or giddiness, seizure (see Section 2: Warnings and precautions)

  • eyesight problems including double vision
  • tinnitus, loss of hearing, impaired hearing
  • rapid heartbeat (tachycardia)
  • expansion of blood vessels (vasodilation), low blood pressure, or fainting
  • shortness of breath, including asthmatic symptoms
  • sensitivity to light (see Section 2: Warnings and precautions)
  • kidney failure, blood or crystals in the urine (see Section 2: Warnings and precautions), urinary tract inflammation
  • fluid retention or excessive sweating
  • increased levels of the enzyme amylase

Very rare (may affect up to 1 in 10,000 people)

• a special type of reduced red blood cell count (haemolytic anaemia); a dangerous drop in a type of white blood cells (agranulocytosis); a drop in the number of red and white blood cells and platelets (pancytopenia), which may be fatal; and bone marrow depression, which may also be fatal (see Section 2: Warnings and precautions)
• allergic reaction called serum sickness-like reaction (see Section 2: Warnings and precautions)
• mental disturbances (psychotic reactions potentially leading to thoughts of suicide, suicide attempts, or completed suicide) (see Section 2: Warnings and precautions)
• migraine, disturbed coordination, unsteady walk (gait disturbance), disorder of sense of smell (olfactory disorders), pressure on the brain (intracranial pressure and pseudotumor cerebri)
• visual colour distortions
• death of liver cells (liver necrosis) very rarely leading to life-threatening liver failure (see Section 2: Warnings and precautions)
• worsening of the symptoms of myasthenia gravis (see Section 2: Warnings and precautions)

Not known (frequency cannot be estimated from the available data)

• pustular rash
• syndrome associated with impaired water excretion and low levels of sodium (SIADH)
• feeling highly excited (mania) or feeling great optimism and overactivity (hypomania), hypersensitivity reaction called DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms)
• influence on blood clotting (in patients treated with Vitamin K antagonists) Cases of an enlargement and weakening of the aortic wall or a tear in the aortic wall (aneurysms and dissections), which may rupture and may be fatal, and of leaking heart valves have been reported in patients receiving fluoroquinolones. See also section 2.

If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, talk to your doctor or pharmacist.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:

www.mhra.gov.uk/yellowcard or search for MHRA yellow card in Google Play or Apple App Store. By reporting side affects you can help provide more information on the safety of this medicine.

5. How to store Ciprofloxacin tablets

• Keep this medicine out of the sight and reach of children
• Do not store above 25°C
• Do not use this medicine after the expiry date which is stated on carton. The expiry date refers to the last day of that month.
• Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. Contents of the pack and other information What Ciprofloxacin tablets contain

The active substance is ciprofloxacin hydrochloride equivalent to 500 mg ciprofloxacin.

The other ingredients are sodium starch glycollate, lactose monohydrate, povidone, sodium stearyl fumarate, Methocel E5 premium, polyethylene glycol, titanium dioxide.

What Ciprofloxacin tablets look like and contents of the pack

Ciprofloxacin 500 mg film coated tablets are off-white, capsule shaped, biconvex, film coated tablets with CP/500 on one side and (k) on the other The film coated tablets come in packs of 10 or 20 but your doctor will prescribe as many as you need.

Marketing Authorisation Holder and Manufacturer:

Marketing Authorisation Holder:

Crescent Pharma Ltd., Key House,

Sarum Hill, Basingstoke, RG21 8SR, UK.

Telephone: 01256 772 730

Email: Safety@crescentpharma.com

Manufacturer:

NOUMED LIFE SCIENCES LIMITED,

Noumed House, Shoppenhangers Road,

Maidenhead, Berkshire, SL6 2RB, UK.

This leaflet was last revised in July 2026.

To listen to or request a copy of this leaflet in Braille, large print or audio please call, above MAH contact details (UK only)

Please be ready to give the following information:

Product name: Reference number: Ciprofloxacin 500 mg film-coated tablets PL 20416/0932

POM

Front side 330mm