Patient leaflet - Ciprofloxacin 100 mg tablets

1. What Ciproﬂoxacin tablets are and what they are used for

Pain and swelling in the joints and inﬂammation or rupture of tendons may occur rarely. Your risk is increased if you are elderly (above 60 years of age), have received an organ transplant, have kidney problems or if you are being treated with corticosteroids.
What you need to know before you take Ciproﬂoxacin tablets
How to take Ciproﬂoxacin tablets
Possible side eﬀects
How to store Ciproﬂoxacin tablets
Inﬂammation and ruptures of tendons may occur even within the ﬁrst 48 hours of treatment or up to several months after discontinuation of Ciproﬂoxacin therapy.
Contents of the pack and other information
What Ciproﬂoxacin tablets are and what they are used for
At the ﬁrst sign of pain or inﬂammation of a tendon (for example in your ankle, wrist, elbow, shoulder or knee), stop taking Ciproﬂoxacin, contact your doctor and rest the painful area. Avoid any unnecessary exercise, as this might increase the risk of a tendon rupture.

The active substance is Ciproﬂoxacin. Ciproﬂoxacin is an antibiotic belonging to the ﬂuoroquinolone family. Ciproﬂoxacin works by killing bacteria that cause infections. It only works with speciﬁc strains of bacteria.

If you feel sudden, severe pain in your abdomen, chest or back, which can be symptoms of aortic aneurysm and dissection, go immediately to an emergency room. Your risk may be increased if you are being treated with systemic corticosteroids.

Adults

Ciproﬂoxacin is used in adults to treat the following bacterial infections:

If you start experiencing a rapid onset of shortness of breath, especially when you lie down ﬂat in your bed, or you notice swelling of your ankles, feet or abdomen, or a new onset of heart palpitations (sensation of rapid or irregular heartbeat), you should inform a doctor immediately.
respiratory tract infections
long lasting or recurring ear or sinus infections • urinary tract infections
genital tract infections in men and women • gastro-intestinal tr act infections a nd intraabdominal infections
If you suﬀer from epilepsy or other neurological conditions such as cerebral ischemia or stroke, you may experience side eﬀects associated with the central nervous system. If seizures happen, stop taking Ciproﬂoxacin and contact your doctor immediately.
skin and soft tissue infections
bone and joint infections
to prevent infections due to the bacterium Neisseria meningitidis
anthrax inhalation exposure
You may rarely experience symptoms of nerve damage (neuropathy) such as pain, burning, tingling, numbness and/ or weakness especially in the feet and legs or hands and arms. If this happens, stop taking Ciproﬂoxacin and contact your doctor immediately.

Ciproﬂoxacin may be used in the management of patients with low white blood cell counts (neutropenia) who have a fever that is suspected to be due to a bacterial infection.

If you have a severe infection or one that is caused by more than one type of bacterium, you may be given additional antibiotic treatment in addition to Ciproﬂoxacin.

Quinolone antibiotics may cause an increase of your blood sugar levels above normal levels (hyperglycaemia) or lowering of your blood sugar levels below normal levels, potentially leading to loss of consciousness (hypoglycaemic coma) in severe cases (see section 4). This is important for people who have diabetes. If you suﬀer from diabetes, your blood sugar should be carefully monitored.

Children and Adolescents

Ciproﬂoxacin is used in children and adolescents, under specialist medical supervision, to treat the following bacterial infections:

lung and bronchial infections in children and adolescents suﬀering from cystic ﬁbrosis • complicated urinary tract infections, including infections that have reached the kidneys (pyelonephritis)
- Diarrhoea may develop while you are taking antibiotics, including Ciproﬂoxacin, or even several weeks after you have stopped taking them. If it becomes severe or persistent or you notice that your stool contains blood or mucus, stop taking Ciproﬂoxacin immediately, as this can be life threatening. Do not take medicines that stop or slow down bowel movements and contact your doctor.
anthrax inhalation exposure

Ciproﬂoxacin may also be used to treat other speciﬁc severe infections in children and adolescents when your doctor considered this necessary.

Tell the doctor or laboratory staﬀ that you are taking Ciproﬂoxacin if you have to provide a blood or urine sample.

2. What you need to know before you take Ciproﬂoxacin tablets

If you suﬀer from kidney problems, tell the doctor because your dose may need to be adjusted.

Do not take Ciproﬂoxacin Tablets if you:

Ciproﬂoxacin may cause liver damage. If you notice any symptoms such as loss of appetite, jaundice (yellowing of the skin), dark urine, itching, or tenderness of the stomach, stop taking Ciproﬂoxacin and contact your doctor immediately.
are allergic to ciproﬂoxacin, to other quinolone drugs or any of the other ingredients of this medicine (listed in section 6).
are taking tizanidine (see Section 2: Other medicines and Ciproﬂoxacin)
Ciproﬂoxacin may cause a reduction in the number of white blood cells and your resistance to infection may be decreased. If you experience an infection with symptoms such as fever and serious deterioration of your general condition, or fever with local infection symptoms such as sore throat pharynx/ mouth or urinary problems you should see your doctor immediately. A blood test will be taken to check possible reduction of white blood cells (agranulocytosis). It is important to inform your doctor about your medicine.

Warnings and Precautions

Before taking this medicine

You should not take ﬂuoroquinolone/quinolone antibacterial medicines, including ciproﬂoxacin, if you have experienced any serious adverse reaction in the past when taking a quinolone or ﬂuoroquinolone.

In this situation, you should inform your doctor as soon as possible. Talk to your doctor or pharmacist or nurse before taking Ciproﬂoxacin tablets if you: • have heart problems. Caution should be taken when using this kind of medicine, if you are born with a family history of prolonged QT interval (seen on ECG, electrical recording of the heart), have salt imbalance in the blood (especially low level of potassium and magnesium in the blood), have a very slow heart rhythm (called bradycardia), have a weak heart (heart failure), have a history of heart attack (myocardial infarction), have a history of abnormal heart rhythms (arrhythmias) you are female or elderly or you are taking other medicines that result in abnormal ECG changes (see section: Other medicines and Ciproﬂoxacin)

Your skin becomes more sensitive to sunlight or ultraviolet (UV) light when taking ciproﬂoxacin. Avoid exposure to strong sunlight, or artiﬁcial UV light such as sunbeds.

Other medicines and Ciproﬂoxacin Tablets

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Do not take Ciproﬂoxacin together with tizanidine, because this may cause side eﬀects such as low blood pressure and sleepiness (See section 2: Do not take Ciproﬂoxacin).

The following medicines are known to interact with Ciproﬂoxacin in your body. Taking Ciproﬂoxacin together with these medicines can inﬂuence the therapeutic eﬀect of those medicines. It can also increase the probability of experiencing side eﬀects.

have ever had kidney problems because your treatment may need to be adjusted
suﬀer from epilepsy or other neurological conditions
have a history of tendon problems during previous treatment with antibiotics such as ciproﬂoxacin • have myasthenia gravis (a type of muscle weak-ness) because symptoms can be exacerbated. • are diabetic because you may experience a risk of hypoglycaemia with ciproﬂoxacin.
Tell your doctor if you are taking:
- Vitamin K antagonists (e.g. warfarin, acenocoumarol, phenprocoumon or ﬂuindione) or other oral anticoagulants (to thin the blood) • probenecid (for gout)
have been diagnosed with an enlargement or “bulge” of a large blood vessel (aortic aneurysm or large vessel peripheral aneurysm).
- methotrexate (for certain types of cancer, psoriasis, rheumatoid arthritis)
- theophylline (for breathing problems)
have experienced a previous episode of aortic dissection (a tear in the aorta wall).
- tizanidine (for muscle spasticity in multiple sclerosis)
have been diagnosed with leaking heart valves (heart valve regurgitation).
- olanzapine (an antipsychotic)
- clozapine (an antipsychotic)
have a family history of aortic aneurysm or aortic dissection or congenital heart valve disease, or other risk factors or predisposing conditions (e.g. connective tissue disorders such as Marfan syndrome, or Ehlers-Danlos syndrome, Turner syndrome, Sjögren’s syndrome [an inﬂammatory autoimmune disease], or vascular disorders such as Takayasu arteritis, giant cell arteritis, Behçet’s disease, high blood pressure, or known atheroscle-rosis, rheumatoid arthritis [a disease of the joints] or endocarditis [an infection of the heart]). • or a member of your family is known to have a deﬁciency in glucose-6 phosphate dehydrogenase (G6PD), since you may experience a risk of anaemia with ciproﬂoxacin.
- ropinirole (for Parkinson’s disease)
- phenytoin (for epilepsy)
- metoclopramide (for nausea and vomiting) • cyclosporin (for skin conditions, rheumatoid arthritis and in organ transplantation)
- other medicines that can alter your heart rhythm: medicines that belong to the group of antiarrhythmics (e.g. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide), tricyclic antidepressants, some antimicrobials (which belong to the group of antiarrhythmics) in the macrolide group), some antipsychotics
- zolpidem (for sleep disorders)
- other drugs that may increase the risk of seizures, such as tramadol, and certain antidepressants belonging to Selective Serotonin Reuptake Inhibitors (such as citalopram, escitalopram, ﬂuoxetine, paroxetine, etc.)

For the treatment of some genital tract infections, your doctor can prescribe another antibiotic in addition to ciproﬂoxacin. If there is no improvement in symptoms after 3 days of treatment, please consult your doctor.

While taking Ciproﬂoxacin Tablets

Ciproﬂoxacin may increase the levels of the following medicines in your blood:

Tell your doctor immediately, if any of the following occurs while taking Ciproﬂoxacin. Your doctor will decide whether treatment with Ciproﬂoxacin needs to be stopped.

pentoxifylline (for circulatory disorders) • caﬀeine
duloxetine (for depression, diabetic nerve damage or incontinence)
Prolonged, disabling and potentially irreversible serious side eﬀects
lidocaine (for heart conditions or anesthetic use) • sildenaﬁl (e.g. for erectile dysfunction)

Fluoroquinolone/quinolone antibacterial medicines, including Ciproﬂoxacin, have been associated with rare but serious side eﬀects, some of them being long lasting (continuing for months or years), disabling or potentially irreversible. This includes tendon, muscle and joint pain of the upper and lower limbs, diﬃculty in walking, abnormal sensations such as pins and needles, tingling, tickling, numbness or burning (paraesthesia), sensory disorders including impairment of vision, taste and smell, and hearing, mental health eﬀects which may include, but are not necessarily limited to, anxiety, panic attacks, confusion, or depression, memory impairment, severe fatigue, and severe sleep disorders. There are no medicines that have been established as being eﬀective treatments for the symptoms of long lasting or disabling side eﬀects associated with ﬂuoroquinolones. If you experience any of these side eﬀects after taking Ciproﬂoxacin, then do not take any further doses and contact your doctor immediately. You and your doctor will decide on whether to continue treatment, considering alternative options.

agomelatine (for depression)

Some medicines reduce the eﬀect of Ciproﬂoxacin. Tell your doctor if you take or wish to take: • antacids

omeprazole
mineral supplements
sucralfate
a polymeric phosphate binder (e.g. sevelamer or lanthanum carbonate)
medicines or supplements containing calcium, magnesium, aluminium or iron

If these preparations are essential, take Ciproﬂoxacin about two hours before or no sooner than four hours after them.

Ciproﬂoxacin tablets with food, drink and alcohol

Severe, sudden allergic reaction (an anaphylactic reaction/shock, angio-oedema). Even with the ﬁrst dose, there is a small chance that you may experience a severe allergic reaction with the following symptoms: tightness in the chest, chest pain, shortness of breath, feeling dizzy, sick or faint, or experiencing dizziness when standing up. If this

Size; 150 x 700 mm

Front

150 mm

Therefore, ciproﬂoxacin should be taken either 1-2 hours before or no earlier than 4 hours after dairy products or calcium-rich beverages taken alone away from meals (see also Section 3).

pains in your muscles and bones, feeling unwell(asthenia), or fever
increase in blood alkaline phosphatase (a certain substance in the blood)

Pregnancy and breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

It is preferable to avoid the use of ciproﬂoxacin during pregnancy.

Do not take ciproﬂoxacin during breast-feeding because it is excreted in breast milk and can be harmful for your child.

Driving and Using Machines

Ciproﬂoxacin may make you feel less alert. Some neurological adverse events can occur. Therefore, make sure you know how you react to Ciproﬂoxacin before driving a vehicle or operating machinery. If in doubt, talk to your doctor.

Information on sodium content

This medicine contains less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodium-free’.

3. How to take Ciproﬂoxacin tablets

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

This will depend on the type of infection you have and how bad it is.

Tell your doctor if you suﬀer from kidney problems because your dose may need to be adjusted.

The treatment usually lasts from 5 to 21 days, but may take longer for severe infections. Take the tablets exactly as your doctor has told you. Ask your doctor or pharmacist if you are not sure how many tablets to take and how to take Ciproﬂoxacin.

a. Swallow the tablets with plenty of liquid. b. Do not chew or crush the tablets. If you are unable to swallow the tablet, please tell your doctor so that he can prescribe another medicine that is more suitable for you.

c. Try to take the tablets at about the same time each day.

d. You can take the tablets with meals or between meals. You can take ciproﬂoxacin tablets during e. meals containing dairy products (such as milk or yogurt) or with calcium-rich beverages (e.g., calcium fortiﬁed orange juice). Do not take Ciproﬂoxacin tablets at the same time as dairy products or with calcium-rich beverages when these dairy products or calcium-rich beverages are taken on their own away from meals. Ciproﬂoxacin tablets should be taken one to two hours before or no earlier than four hours after dairy products or calcium-rich beverages taken on their own away from meals.

Remember to drink plenty of ﬂuids while you are taking Ciproﬂoxacin.

If you take more Ciproﬂoxacin Tablets than you should:

If you take more than the prescribed dose, get medical help immediately. If possible, take your tablets or the box with you to show the doctor.

Rare (may aﬀect up to 1 in 1000 people):

inﬂammation of the bowel (colitis) linked to antibiotic use (can be fatal in very rare cases) (see Section 2: Warnings and Precautions)
changes to the blood count (leucopenia, leucocytosis, neutropenia, anaemia), increased or decreased amounts of a blood clotting factor (thrombocytes)
allergic reaction, swelling (oedema), or rapid swelling of the skin and mucous membranes (angio-oedema) (see Section 2: Warnings and precautions)
increased blood sugar (hyperglycaemia)
decreased blood sugar (hypoglycaemia) (see Section 2: Warnings and precautions)
confusion, disorientation, anxiety reactions, strange dreams, depression, (potentially leading to thoughts of suicide, suicide attempts, or completed suicide) (see Section 2: Warnings and precautions) or hallucinations
pins and needles, unusual sensitivity to stimuli of the senses, decreased skin sensitivity, tremors, or giddiness
eyesight problems including double vision (see Section 2: Warnings and precautions)
tinnitus, loss of hearing, impaired hearing
rapid heartbeat (tachycardia)
expansion of blood vessels (vasodilation), low blood pressure, or fainting
shortness of breath, including asthmatic symptoms
liver disorders, jaundice (cholestatic icterus), or hepatitis
sensitivity to light (see Section 2: Warnings and precautions)
muscle pain, inﬂammation of the joints, increased muscle tone and cramping
kidney failure, blood or crystals in the urine, urinary tract inﬂammation
ﬂuid retention or excessive sweating
increased levels of the enzyme amylase

Very rare (may aﬀect up to 1 in 10,000 people):

a special type of reduced red blood cell count (haemolytic anaemia); a dangerous drop in a type of white blood cells (agranulocytosis); (see Section 2: Warnings and precautions) a drop in the number of red and white blood cells and platelets (pancytopenia), which may be fatal; and bone marrow depression, which may also be fatal
allergic reaction called serum sickness-like reaction (see Section 2: Warnings and precautions)
mental disturbances (psychotic reactions potentially leading to thoughts of suicide, suicide attempts, or completed suicide) (see Section 2: Warnings and Precautions)
migraine, disturbed coordination, unsteady walk (gait disturbance), disorder of sense of smell (olfactory disorders), pressure on the brain (intracranial pressure and pseudotumor cerebri)
visual colour distortions
inﬂammation of the wall of the blood vessels (vasculitis)
pancreatitis
death of liver cells (liver necrosis) very rarely leading to life-threatening liver failure (see Section 2: Warnings and precautions)
small, pin-point bleeding under the skin (petechiae); various skin eruptions or rashes
worsening of the symptoms of myasthenia gravis (see Section 2: Warnings and precautions)

If you forget to take Ciproﬂoxacin Tablets and are:

6 hours or more until the next scheduled dose, take your missed dose immediately. Then take the next dose at your normal time.
less than 6 hours until the next scheduled dose, do not take the missed dose. Take the next dose at your normal time.

Do not take a double dose to make up for the forgotten dose. Make sure you have completed your treatment.

If you stop taking Ciproﬂoxacin Tablets:

It is important that you ﬁnish the course of treatment even if you begin to feel better after a few days. If you stop taking this medicine too soon, your infection may not be completely cured and the symptoms of the infection may return or get worse. You might also develop resistance to the antibiotic.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

4. Possible side eﬀects

Like all medicines, this medicine can cause side eﬀects, although not everybody gets them.

Severe allergic reactions can occur very rarely. These can happen after the ﬁrst dose or even after the treatment has stopped.

The following section contains the most serious side eﬀects that you can recognize yourself:

Stop taking Ciproﬂoxacin and contact your doctor immediately in order to consider another antibiotic treatment if you notice any of the following serious side eﬀects:

Rare (may aﬀect up to 1 in 1,000 people)

Very rare cases of long lasting (up to months or years) or permanent adverse drug reactions, such as tendon inﬂammations, tendon rupture, joint pain, pain in the limbs, diﬃculty in walking, abnormal sensations such as pins and needles, tingling, tickling, burning, numbness or pain (neuropathy), fatigue, memory and concentration impairment, mental health eﬀects (which may include sleep disorders, anxiety, panic attacks, depression and suicidal ideation), as well as impairment of hearing, vision, and taste and smell have been associated with administration of quinolone and ﬂuoroquinolone antibiotics, in some cases irrespective of pre-existing risk factors.
Seizure (see Section 2: Warnings and precautions)

Very rare (may aﬀect up to 1 in 10,000 people)

Severe, sudden allergic reaction with symptoms such as tightness in the chest, feeling dizzy, sick or faint, or experience dizziness when standing up (anaphylactic reaction/shock) (see Section 2: Warnings and precautions)
Muscle weakness, inﬂammation of the tendons which could lead to rupture of the tendon, particularly aﬀecting the large tendon at the back of the ankle (Achilles tendon) (see Section 2: Warnings and precautions)
A serious life-threatening skin rash, usually in the form of blisters or ulcers in the mouth, throat, nose, eyes and other mucous membranes such as genitals which may progress to widespread blistering or peeling of the skin (Stevens-Johnson syndrome, toxic epidermal necrolysis).

Not known (frequency cannot be estimated from the available data)

Unusual feelings of pain, burning tingling, numbness or muscle weakness in the extremities (neuropathy) (see Section 2: Warnings and precautions)
A drug reaction that causes rash, fever, inﬂammation of internal organs, hematologic abnormalities and systemic illness (DRESS syndrome i.e. Drug Reaction with Eosinophilia and Systemic Symptoms, AGEP syndrome i.e. Acute Generalised Exanthematous Pustulosis).
Chest pain, which can be a sign of a potentially serious allergic reaction called Kounis syndrome.

These are very serious side-eﬀects requiring immediate attention which are potentially life threatening.

Other side eﬀects which have been observed during treatment with Ciproﬂoxacin are listed below by how likely they are:

Common (may aﬀect up to 1 in 10 people):

nausea, diarrhoea
Joint inﬂammation and joint pain in children

Uncommon (may aﬀect up to 1 in 100 people):

fungal superinfections
a high concentration of eosinophils, a type of white blood cell
decreased appetite (anorexia)
hyperactivity or agitation
headache, dizziness, sleeping problems, or taste disorders
vomiting, abdominal pain, digestive problems such as stomach upset (indigestion/heartburn), or wind
increased amounts of certain substances in the blood (transaminases and/or bilirubin)
rash, itching, or hives
joint pain in adults
poor kidney function
Not known (cannot be estimated from the available data):
- syndrome associated with impaired water excretion and low levels of sodium (SIADH)
- feeling highly excited (mania) or feeling great optimism and overactivity (hypomania)
- abnormal fast heart rhythm, life-threatening irregular heart rhythm, alteration of the heart rhythm (called ‘prolongation of QT interval’, seen on ECG, electrical activity of the heart)
- inﬂuence on blood clotting (in patients treated with Vitamin K antagonists)
- loss of consciousness due to severe decrease in blood sugar levels (hypoglycaemic coma). See section 2.
- Fixed drug eruption

Very rare cases of long-term (up to months or years) or permanent side eﬀects of the drug, such as tendon inﬂammation, tendon rupture, joint pain, pain in the limbs, diﬃculty walking, abnormal sensations such as pinching, tingling, tickling, burning, numbness or pain (neuropathy), fatigue, impaired memory and concentration; Mental health eﬀects (which may include sleep disturbances, anxiety, panic attacks, depression, and suicidal ideation), as well as hearing, vision, taste, and smell disorders, have been associated with the administration of antibiotic quinolones and ﬂuoroquinolones, in some cases independent of preexisting risk factors.

Cases of an enlargement and weakening of the aortic wall or a tear in the aortic wall (aneurysms and dissections), which may rupture and may be fatal, and of leaking heart valves have been reported in patients receiving ﬂuoroquinolones. See also section 2.

Reporting of side eﬀects

If you get any side eﬀects, talk to your doctor, pharmacist or nurse. This includes any possible side eﬀects not listed in this leaﬂet. You can also report side eﬀects directly via the Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow card in the Google Play or Apple App Store. By reporting side eﬀects you can help provide more information on the safety of this medicine.

5. How to store Ciproﬂoxacin tablets

Keep this medicine out of the sight and reach of children
Blisters: Do not store above 250C. Store in the original package
Tablet Containers: Do not store above 250C. Keep the container tightly closed.
Do not use this medicine after the expiry date which is stated on the carton after {EXP.}. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. Contents of the pack and other information

What Ciproﬂoxacin tablets contain

The active ingredient is ciproﬂoxacin (as hydrochloride).
Each tablet contains either 100mg, 250mg, 500mg or 750mg of the active ingredient.
The other ingredients are maize starch, microcrystallinecellulose, colloidal anhydrous silica, sodium starch glycollate, magnesium stearate, hypromellose, puriﬁed talc, polyethylene glycol, titanium dioxide E171.

What Ciproﬂoxacin tablets look like and contents of the pack

The 100 mg tablets are white to creamish white round ﬁlm-coated tablets- debossed “CPR 100” on one side and “BL” on the reverse.
The 250 mg tablets are white to creamish white round ﬁlm-coated tablets debossed “CPR 250” on one side and “BL” on the reverse.
The 500 mg tablets are white to creamish white capsule shaped ﬁlm-coated tablets debossed “CPR 500” with a breakline one side and “BL” on the reverse.
The 750 mg tablets are white to creamish white capsule shaped ﬁlm coated tablets debossed “CPR 750” on one side and “BL”on the reverse. • The tablets come in packs containing 6, 10, 20, 100, 250 or 500 tablets.
Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Bristol Laboratories Ltd,

Unit 3, Canalside, Northbridge Road, Berkhamsted, Hertfordshire, HP4 1EG, United Kingdom Telephone: 0044 (0)1442 200922

E-mail: info@bristol-labs.co.uk

Ciproﬂoxacin 100 mg Tablets; PL 17907/0013 Ciproﬂoxacin 250 mg Tablets; PL 17907/0014 Ciproﬂoxacin 500 mg Tablets; PL 17907/0015 Ciproﬂoxacin 750 mg Tablets; PL 17907/0016

This leaﬂet was last revised in August 2026.

To request a copy of this leaﬂet in Braille, large print or audio format, please contact the licence holder at the address (telephone or email) above.

V36 31-08-26 D0