Wegovy® 0.25mg FlexTouch® solution for injection in – patient leaflet, side effects, dosage

1. What Wegovy is and what it is used for

What Wegovy is

Wegovy is a medicine for weight loss and weight maintenance that contains the active substance semaglutide. It is similar to a natural hormone called glucagon-like peptide-1 (GLP-1) that is released from the intestine after a meal. Wegovy works by acting on receptors in the brain that control your appetite, causing you to feel fuller and less hungry and experience less craving for food. This will help you eat less food and reduce your body weight. Wegovy should be used with a reduced calorie meal plan and increased physical activity.

What Wegovy is used for

Weight management

Wegovy is used for weight loss and weight maintenance in addition to diet and physical activity in adults, who have:

• a BMI of 30kg/m² or greater (with obesity) or

• a BMI of 27kg/m² and less than 30kg/m² (overweight) and weight-

  related health problems.

BMI (Body Mass Index) is a measure of your weight in relation to your height.

Wegovy is used together with diet and physical activity for weight management in adolescents ages 12 years and above, who have

• obesity
• body weight >60kg

As an adolescent patient, you should only continue using Wegovy if you have lost at least 5% of your BMI after 12 weeks on the 2.4mg dose or maximum tolerated dose (see section 3). Consult your doctor before you continue.

Risk reduction of serious heart issues in adults

Wegovy is used in addition to diet and physical activity to reduce the risk of serious heart issues (heart-related death, heart attacks, strokes) in adults with a history of heart disease (like a heart attack, stroke or poor blood flow to the limbs) and either obesity or overweight (BMI ≥27kg/m²).

2. What you need to know before you use Wegovy

Do not use Wegovy if you are allergic to semaglutide or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Talk to your doctor, pharmacist or nurse before using Wegovy or during treatment if you have:

• Effects on the digestive system

  During treatment with Wegovy, you may feel sick (nausea) or be sick (vomiting), or have diarrhoea. These side effects can cause dehydration (loss of fluids). It is important that you drink enough fluids to prevent dehydration. This is especially important if you have kidney problems. Talk to your doctor if you have any questions or concerns.

• Inflammation of the pancreas

  If you have ever had pancreatitis (inflammation of the pancreas) which may cause severe pain in the stomach and back which does not go away; see section 4.

• Diabetes

  Wegovy must not be used as a substitute for insulin.

• Low blood sugar (hypoglycaemia)

  Wegovy can cause low blood sugar. Please see section 4 for the warning signs of low blood sugar levels. If you have diabetes and are taking a sulfonylurea or an insulin with Wegovy the risk of getting low blood sugar levels (hypoglycaemia) might increase. Your doctor may ask you to test your blood sugar levels. This will help your doctor decide if the dose of the sulfonylurea or insulin needs to be changed to reduce the risk of low blood sugar.

• Diabetic eye disease (retinopathy)

  Fast improvements in blood sugar control may lead to a temporary worsening of diabetic eye disease. If you have diabetic eye disease and experience eye problems while taking this medicine, talk to your doctor.

• Sudden changes to your eyesight

  If you notice a sudden loss of vision or rapidly worsening eyesight during treatment with semaglutide, urgently contact your doctor. This may be caused by a very rare side effect called non-arteritic anterior ischaemic optic neuropathy (NAION) (See section 4: Serious side effects). Your doctor will refer you for an eye examination by an ophthalmologist and you may have to stop treatment with semaglutide.

  • Patients with delayed stomach emptying (gastroparesis)

    If you have slow (delayed) stomach emptying (called gastroparesis), use of wegovy may lead to serious or severe gastrointestinal adverse events. Talk to your doctor before using wegovy.

If you know that you are due to have surgery where you will be under anaesthesia (sleeping), please tell your doctor that you are taking wegovy.

Children and adolescents

The safety and efficacy of Wegovy in children below 12 years of age have not been studied and are not recommended for use in this population.

Other medicines and Wegovy

Tell your doctor, pharmacist or nurse if you are using, have recently used or might use any other medicines.

In particular, tell your doctor, pharmacist or nurse if you are using medicines containing the following:

• Warfarin or other similar medicines taken by mouth to reduce

  blood clotting (oral anti-coagulants). When you start treatment with e.g. warfarin or similar medicines, frequent blood testing to determine the ability of your blood to clot may be required.

Pregnancy and breast-feeding

This medicine should not be used during pregnancy, as it is not known if it may affect your unborn child. Therefore, it is recommended to use contraception while using this medicine. If you wish to become pregnant, you should stop using this medicine at least two months in advance. If you become or are pregnant, think you may be pregnant or are planning to have a baby when using this medicine, talk to your doctor straight away, as your treatment will need to be stopped.

You should not use this medicine if you are breast-feeding, as it is unknown if it passes into breast milk.

Driving and using machines

Wegovy is unlikely to affect your ability to drive and use machines. Some patients may feel dizzy when taking Wegovy mainly during the first 3 months of treatment (see section 4). If you feel dizzy you should not drive or operate machines until you feel better. If you need any further information, talk to your doctor, pharmacist or nurse.

For diabetics using this medicine in combination with a sulfonylurea or insulin, low blood sugar (hypoglycaemia) may occur which may reduce your ability to concentrate. Do not drive or use machines if you get any signs of low blood sugar. See section 2, ‘Warning and precautions’ for information on increased risk of low blood sugar and section 4 for the warning signs of low blood sugar. Talk to your doctor for further information.

Sodium content

This medicine contains less than 1mmol sodium (23mg) per dose, i.e. essentially ‘sodium-free’.

3. How to use Wegovy

Always use this medicine exactly as your doctor has told you. Check with your doctor, pharmacist or nurse if you are not sure.

How much to use

Adults

For weight management and risk reduction of serious heart issues Your treatment will start at a low dose which will be gradually increased over 16 weeks of treatment as follows:

• When you first start using Wegovy, the starting dose is 0.25mg

  once weekly.

• Your doctor will instruct you to gradually increase your dose every

  4 weeks until you reach the dose of 2.4mg once weekly. For weight management in patients with obesity

• If needed, a dose increase to the next maintenance dose 7.2mg

  once weekly (3 injections of 2.4mg) can be made after a minimum of 4 weeks on 2.4mg.

• The maximum dose is 7.2mg once weekly.

You will be told to follow the relevant table below.

For weight management

For risk reduction of serious heart issues in adults

Your doctor will assess your treatment on a regular basis.

Adolescents (above 12 years of age)

For adolescents, the same dose escalation schedule as for adults should be applied (see above). The dose should be increased until 2.4mg (maintenance dose) or maximum tolerated dose has been reached. Weekly doses higher than 2.4mg are not recommended.

How Wegovy is given

Wegovy is given as an injection under the skin (subcutaneous injection). Do not inject it into a vein or muscle.

• The best places to give the injection are the upper arms, stomach

  or upper legs.

• Before you use the pen for the first time, ask your doctor or nurse

  how to use it.

For the wegovy 7.2mg weight management dose

• you will need to inject three doses of 2.4mg, one after each other

  on the same day.

• the injections can be given in the same body area but should be at

  least 5 cm apart.

• you must change the needle between each dose.

• you may need to use multiple pens. Do not discard the pen until it

  is empty. Partially used pens must be stored in the fridge with the needle removed.

  • make sure you have a sufficient supply of pens to complete your

    dose before you start injecting.

Detailed instructions for use are on the other side of this leaflet.

People with diabetes

Tell your doctor if you have diabetes. Your doctor may adjust the dose of your diabetes medicines to prevent you from getting low blood sugar.

• Do not mix Wegovy up with other medicines that you inject (e.g.

  insulins).

• Do not use Wegovy in combination with other medicines that

  contain GLP-1 receptor agonists (such as liraglutide, dulaglutide, exenatide or lixisenatide).

When to use Wegovy

• You should use this medicine once a week and if possible, on the

  same day each week.

• You can give yourself the injection at any time of the day –

  regardless of meals.

If necessary, you can change the day of your weekly injection of this medicine as long as it has been at least 3 days since your last injection. After selecting a new dosing day, continue with once a week dosing.

If you use more Wegovy than you should

Talk to your doctor straight away. You may get side effects such as feeling sick (nausea).

If you forget to use Wegovy

If you forgot to inject a dose and:

• it is 5 days or less since you should have used Wegovy, use it as

  soon as you remember. Then inject your next dose as usual on your scheduled day.

• it is more than 5 days since you should have used Wegovy, skip

  the missed dose. Then inject your next dose as usual on your next scheduled day. Do not take a double dose to make up for a forgotten dose.

If you stop using Wegovy

Do not stop using this medicine without talking to your doctor. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Serious side effects

Common: may affect up to 1 in 10 people

• Complications of diabetic eye disease (diabetic retinopathy). If you

  have diabetes you should inform your doctor if you experience eye problems, such as changes in vision, during treatment with this medicine.

Uncommon: may affect up to 1 in 100 people

• Inflamed pancreas (acute pancreatitis) which could cause severe

  pain in the stomach and back which does not go away. This is a serious, potentially life-threatening condition. You should see a doctor immediately if you experience such symptoms. Stop using this medicine and seek urgent medical help if you experience: Severe, persistent pain in the stomach area (abdomen), with or without nausea and vomiting. This could be a sign of acute pancreatitis, which is serious and potentially life-threatening.

• Kidney or bladder stones. Signs may include back or lower

  abdomen pain, difficulty in urination or change in colour of your urine.

Rare: may affect up to 1 in 1,000 people

• Severe allergic reactions (anaphylactic reactions, angioedema).

  You should seek immediate medical help and inform your doctor straight away if you get symptoms such as breathing problems, swelling of face, lips, tongue, and/or throat with difficulty swallowing, wheezing, fast heartbeat, pale and cold skin, feeling dizzy or weak

• Hip fractures.

Very rare: may affect up to 1 in 10,000 people

• A medical condition of the eye called non-arteritic anterior

  ischaemic optic neuropathy (NAION), which may cause loss of vision without any pain. You should urgently contact your doctor if you notice sudden or gradually worsening eyesight (see section 2: ‘Sudden changes to your eyesight’).

Not known (frequency cannot be estimated from the available data)

• Bowel obstruction. A severe form of constipation with additional

  symptoms such as stomach ache, bloating, vomiting etc.

Other side effects

Very common: may affect more than 1 in 10 people

• headache
• feeling sick (nausea)
• being sick (vomiting)
• diarrhoea
• constipation
• stomach pain
• feeling weak or tired.

These usually go away over time.

Common: may affect up to 1 in 10 people

• feeling dizzy
• upset stomach or indigestion
• burping
• gas (flatulence)
• bloating of the stomach

• inflamed stomach (‘gastritis’) – the signs include stomach ache,

  feeling sick (nausea) or being sick (vomiting)

• reflux or heartburn – also called ‘gastro-oesophageal reflux

  disease’

• gallstones
• hair loss – may occur more frequently with semaglutide 7.2mg
• injection site reactions
• change in the way food or drink tastes

• changed skin sensation – this usually goes away over time and

  may happen more frequently with semaglutide 7.2mg

• low blood sugar (hypoglycaemia) in patients with diabetes.

  The warning signs of low blood sugar may come on suddenly. They can include: cold sweat, cool pale skin, headache, fast heartbeat, feeling sick (nausea) or very hungry, changes in vision, feeling sleepy or weak, feeling nervous, anxious or confused, difficulty concentrating or shaking.

  Your doctor will tell you how to treat low blood sugar and what to do if you notice these warning signs.

  Low blood sugar is more likely to happen if you also take a sulfonylurea or insulin. Your doctor may reduce your dose of these medicines before you start using this medicine.

  Uncommon: may affect up to 1 in 100 people

  • low blood pressure
  • feeling dizzy or lightheaded on standing or sitting up because of a drop in blood pressure
  • fast heartbeat

  • increase of pancreatic enzymes (such as lipase and amylase)

    shown in blood tests

  • a delay in the emptying of the stomach
  • low blood sugar (hypoglycaemia) in patients without diabetes
  • increased levels of bilirubin in your blood. Signs include jaundice which is yellowing of the skin or the whites of your eyes.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

By reporting side effects, you can help provide more information on the safety of this medicine.

5. How to store Wegovy

Keep out of the sight and reach of children.

Do not freeze Wegovy and do not use it if it has been frozen. Keep the pen cap on in order to protect from light.

Before opening:

Store in a refrigerator (2°C to 8°C). Keep away from the cooling element.

During use:

You can keep the pen for 6 weeks when stored at a temperature below 30°C or in a refrigerator (2°C to 8°C) away from cooling element.

Do not use this medicine after the expiry date, which is stated on the carton and pen labels after ‘Exp’. The expiry date refers to the last day of that month.

Do not use this medicine if you notice that the solution is not clear and colourless or shows any signs of deterioration, seek the advice of your pharmacist.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Contents of the pack and other information

What Wegovy contains

The active ingredient in the Wegovy is semaglutide. Each pre-filled pen contains 1mg semaglutide in 1.5mL (0.68mg/mL) solution for injection. Each dose contains 0.25mg semaglutide in 0.37mL solution.

The other ingredients are disodium phosphate dihydrate, propylene glycol, phenol, sodium hydroxide/hydrochloric acid (for pH adjustment) and water for injections.

What Wegovy looks like and contents of the pack

Wegovy is a clear and colourless solution for injection in a pre-filled disposable pen.

Each FlexTouch pen contains four doses. After having injected the 4 doses, there might still be solution left in the pen despite having administered correctly. Any solution left is insufficient for a dose and the pen should be disposed of.

It is available in pack size of 1 pre-filled pen and 4 disposable NovoFine^® Plus needles.

Your pen is designed to be used with NovoFine^® Plus, NovoFine^® or NovoTwist^® disposable needles up to a length of 8mm.

Manufactured by:

If the second and third characters are P5, W5 or FG, the manufacturer is Novo Nordisk A/S, Novo Alle, DK-2880 Bagsvaerd, Denmark. OR

If the second and third characters are T6, the manufacturer is Novo Nordisk Production SAS, 45, Avenue d’Orleans, 28000 Chartres, France.

Procured from within the EU & repackaged by the Product Licence holder: B&S Healthcare, Unit 4, Bradfield Road, Ruislip, Middlesex, HA4 0NU, UK.

Wegovy^® 0.25mg FlexTouch^® solution for injection in pre-filled pen; PL 18799/4129

Leaflet date: 15.05.2026

Wegovy, FlexTouch, Novofine and NovoTwist are the registered trademarks of Novo Nordisk A/S.

Blind or partially sighted?

Is this leaflet hard to see or read? Call 0208 515 3763 to obtain the leaflet in a format suitable for you.

POM

Only check the Wegovy flow before your first injection with each new pen.

If your Wegovy pen is already in use, go to ‘2 Set your dose’.

Turn the dose selector until you see the flow check symbol ( ).

Make sure the flow check symbol lines up with the dose pointer.

Check the flow

Hold the pen with the needle pointing up.

Press and hold in the dose button until the dose counter returns to .

The must line up with the dose pointer.

A drop of Wegovy should appear at the needle tip. This drop indicates that your pen is ready for use.

If a drop does not appear, check the flow again. This should only be done twice.

If there is still no drop, change the needle and check the flow once more.

Do not use the pen if a drop of Wegovy still does not appear. Check the flow with each new pen

Turn the dose selector until the dose counter stops, and it shows your prescribed dose.

The dashed line (¦) in the dose counter will guide you to your dose.

The dose selector clicks differently when turned forward, backwards or past your dose. You will hear a ‘click’ every time you turn the dose selector. Do not set the dose by counting the number of clicks you hear.

When your prescribed dose lines up with the dose pointer, you have selected your dose. In this picture, the dose is shown as an example.

If the dose counter stops before you reach your prescribed dose, see the section ‘Do you have enough Wegovy?’ below these instructions.

0.25mg

Choose your injection site

Choose upper arms,

stomach or upper legs

(keep a 5cm distance from your belly button).

You may inject in the same body area, but make sure it is not in the same spot as used the last time.

If you are injecting 3x2.4mg (7.2mg) injections on the same day, you may inject in the same body area but

make sure each injection is at least 5cm apart.

Insert the needle into your skin.

Make sure you can see the dose counter. Do not cover it with your fingers. This could interrupt the injection.

Press and hold down the dose button until the dose counter shows .

Keep pressing the dose button with the needle in your skin and slowly count to 6. The must line up with the dose pointer. You may hear or feel a click when the dose counter returns to .

Remove the needle from your skin.

If the needle is removed earlier, a stream of Wegovy may come from the needle tip and the full dose will not be delivered.

If blood appears at the injection site, press lightly on the area to stop the bleeding.

You may see a drop of Wegovy at the needle tip after injecting. This is normal and does not affect your dose. Inject your dose

3

Lead the needle tip into the outer needle cap on a flat surface without touching the needle or the outer needle cap.

Once the needle is covered, carefully push the outer needle cap completely on.

Unscrew the needle and dispose of it carefully as instructed by your doctor, nurse, pharmacist or local authorities.

Never try to put the inner needle cap back on the needle. You may stick yourself with the needle.

Always dispose of the needle immediately after each injection to prevent blocked needles, contamination, infection and inaccurate dosing. Never store your pen with the needle attached.

If you are injecting 3x2.4mg (7.2mg) injections on the same day, place a new needle on the pen as described in step 1 (pictures A to E) and perform the second and third injections as per step 2 and 3 above.

Put the pen cap on your pen after each use to protect Wegovy from light.

When the pen is empty, dispose of the pen without a needle on as instructed by your doctor, nurse, pharmacist or local authorities.

The pen cap and the empty carton can be disposed of in your household waste.

After your injection 4

Example: 0.25mg selected

Upper arms

Stomach

Upper legs

Set your dose 2

1

Dashed line

Check the name and dose of your pen to make sure it contains your prescribed dose of Wegovy.

Pull off the pen cap.

Check that the Wegovy in your pen is clear and colourless. Look through the pen window. If Wegovy looks cloudy or coloured, do not use the pen.

Always use a new needle for each injection, including between the injections for the 3x2.4mg (7.2mg) dose.

Take a needle when you are ready to take your

injection. Check the paper tab and the outer needle cap for damages. If you see any damage, this

could affect sterility.

Dispose of it and use a

new needle.

Tear off the paper tab.

Push the needle straight onto the pen. Turn until it is on tight.

The needle is covered by two caps. You must

remove both caps. If

you forget to remove both caps you will not inject

any Wegovy.

Pull off the outer needle cap and keep it for later. You will need it to safely remove the needle from the pen after the injection.

Pull off the inner needle cap and dispose of it.

A drop of Wegovy may

appear at the needle tip. You must still check the Wegovy flow if you use a new pen for the first time. See ‘Check the flow with each new pen’.

Never use a bent or

damaged needle. For more information about needle handling, see ‘About your needles’ below these instructions.

Prepare your pen with a new needle 1

Count slowly:

1-2-3-4-5-6 ^A

B

C

D

E

F

G

H

I

J

L

M

O

Q

P

R

K