Patient leaflet - Virdev 25 mg film-coated tablets
1. What Virdev is and what it is used for
Virdev contains the active substance tenofovir alafenamide. This is an antiviral medicine, known as a nucleotide reverse transcriptase inhibitor (NtRTI).
Virdev is used to treat chronic (long-term) hepatitis B in adults and children 6 years of age and older, who weigh at least 25 kg. Hepatitis B is an infection affecting the liver, caused by the hepatitis B virus. In patients with hepatitis B, this medicine controls the infection by stopping the virus from multiplying.
2. What you need to know before you take Virdev
Do not take Virdev
if you are allergic to tenofovir alafenamide or any of the other ingredients of this medicine (listed in section 6).
If this applies to you, do not take Virdev and tell your doctor immediately.
Warnings and precautions
- Take care not to pass on your hepatitis B to other people. You can still infect others when taking this medicine. This medicine does not reduce the risk of passing on hepatitis B to others through sexual contact or blood contamination. You must continue to take precautions to avoid this. Discuss with your doctor the precautions needed to avoid infecting others.
- Tell your doctor if you have a history of liver disease. Patients with liver disease, who are treated for hepatitis B with antiviral medicines, have a higher risk of severe and potentially fatal liver complications. Your doctor may need to carry out blood tests to monitor your liver function.
- Talk to your doctor or pharmacist if you have had kidney disease or if tests have shown problems with your kidneys, before or during treatment. Before starting treatment and during treatment with Virdev, your doctor may order blood or urine tests to monitor how your kidneys work.
- Talk to your doctor if you also have hepatitis C or D. This medicine has not been tested on patients who have hepatitis C or D as well as hepatitis B.
Talk to your doctor if you also have HIV. If you are not sure whether you have HIV, your doctor should offer you HIV testing before you start taking this medicine for hepatitis B.
If any of these apply to you, talk to your doctor before taking Virdev.
There is a possibility that you may experience kidney problems when taking Virdev over a long period of time (see Warnings and precautions).
Children and adolescents
Do not give this medicine to children who are under 6 years old, or weighing less than 25 kg. It has not been tested in children aged less than 6 years old or weighing less than 25 kg.
Bone problems. Loss of bone mass has been reported in some children who received Virdev. The effects on long-term bone health and future fracture risk in children are uncertain. Your doctor will monitor this possible risk. Tell your doctor if any bone pain or fractures occur.
Other medicines and Virdev
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Virdev may interact with other medicines. As a result, the amounts of Virdev or other medicines in your blood may change. This may stop your medicines from working properly, or may make any side effects worse.
Medicines used in treating hepatitis B infection
You should not take this medicine with other medicines containing:
- tenofovir alafenamide
- tenofovir disoproxil
- adefovir dipivoxil.
Other types of medicines
Talk to your doctor if you are taking:
antibiotics used to treat bacterial infections including tuberculosis, containing:
- rifabutin, rifampicin or rifapentine
antiviral medicines used to treat HIV, such as:
- ritonavir or cobicistat boosted darunavir, lopinavir or atazanavir
anticonvulsants used to treat epilepsy, such as:
- carbamazepine, oxcarbazepine, phenobarbital or phenytoin
herbal remedies used to treat depression and anxiety, containing:
- St. John’s wort (Hypericum perforatum)
antifungal medicines used to treat fungal infections, containing:
ketoconazole or itraconazole
Tell your doctor if you are taking these or any other medicines.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
- Tell your doctor immediately if you become pregnant.
- Do not breast-feed during treatment with Virdev. It is recommended that you do not breast-feed to avoid passing tenofovir alafenamide or tenofovir to the baby through breast milk.
Driving and using machines
Virdev can cause dizziness. If you feel dizzy when taking Virdev, do not drive and do not use any tools or machines.
Virdev contains lactose
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
Virdev contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.
3. How to take Virdev
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
The recommended dose is one tablet once a day with food. It is best to take Virdev with food to get the right levels of active substance in your body. Treatment should continue for as long as your doctor tells you. Usually this is for at least 6 to 12 months and may be for many years.
If you take more Virdev than you should
If you accidentally take more than the recommended dose of Virdev you may be at increased risk of experiencing possible side effects with this medicine (see section 4, Possible side effects).
Contact your doctor or nearest emergency department immediately for advice. Keep the tablet bottle with you so that you can easily describe what you have taken.
If you forget to take Virdev
It is important not to miss a dose. If you do miss a dose, work out how long since you should have taken it.
- If it is less than 18 hours after you usually take Virdev, take it as soon as you can, and then take your next dose at its regular time.
- If it is more than 18 hours after you usually take Virdev, then do not take the missed dose. Wait and take the next dose at the regular time. Do not take a double dose to make up for a forgotten tablet.
If you are sick (vomit) less than 1 hour after taking Virdev, take another tablet. You do not need to take another tablet if you are sick (vomit) more than 1 hour after taking Virdev.
If you stop taking Virdev
Do not stop taking Virdev without your doctor’s advice. Stopping treatment with Virdev may cause your hepatitis B to get worse. In some patients with advanced liver disease or cirrhosis, this could be life-threatening. If you stop taking this medicine, you will need regular health checks and blood tests for several months to check your hepatitis B infection.
- Talk to your doctor before you stop taking this medicine for any reason, particularly if you are experiencing any side effects or you have another illness.
Tell your doctor immediately about new or unusual symptoms after you stop treatment, particularly symptoms you associate with hepatitis B infection.
- Talk to your doctor before you restart taking Virdev tablets.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Very common
(may affect more than 1 in 10 people)
- Headache.
Common
(may affect up to 1 in 10 people)
- Diarrhoea
- Being sick (vomiting)
- Feeling sick (nausea)
- Dizziness
- Stomach pain
- Joint pain (arthralgia)
- Rash
- Itchiness
- Feeling bloated
- Wind (flatulence)
- Feeling tired.
Uncommon
(may affect up to 1 in 100 people)
- Swelling of the face, lips, tongue or throat (angioedema)
- Hives (urticaria).
Tests may also show:
Increased level of a liver enzyme (ALT) in the blood.
If any of these side effects get serious tell your doctor.
During HBV therapy there may be an increase in weight, fasting levels of blood lipids and/or glucose. Your doctor will test for these changes.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the
Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
By reporting side effects you can help provide more information on the safety of this medicine.
5. How to store Virdev
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the bottle and carton after ‘EXP’. The expiry date refers to the last day of that month.
Store below 25°C.
Store in the original package in order to protect from moisture. Keep the bottle tightly closed.
Use within 2 months after first opening of the container.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Virdev contains
- The active substance is tenofovir alafenamide.
Each film-coated tablet contains 25 mg tenofovir alafenamide (as monofumarate).
- The other ingredients are:
tablet core: lactose monohydrate, microcrystalline cellulose (type 112), croscarmellose sodium and magnesium stearate
film-coating: poly(vinyl alcohol), partly hydrolysed, macrogol 3350, talc, titanium dioxide (E171) and iron oxide yellow (E172)
What Virdev looks like and contents of the pack
Virdev are yellow, round film-coated tablets (diameter 8mm and thickness 4mm), debossed with “25” on one side.
They come in bottles of 30 tablets.
Each bottle contains a silica gel desiccant in a separate canister. It must be kept in the bottle to help protect your tablets and should not be swallowed.
The following pack sizes are available:
Bottles of 30 film-coated tablets and multipacks containing 90 (3 bottles of
- 30) film-coated tablets.
Not all pack sizes may be marketed.
Marketing Authorisation Holder
Devatis UK Limited
Lower GF Suite (LG35)
Belvedere House,
Basingstoke,
Hampshire,
United Kingdom,
RG21 4HG
Manufacturer
Devatis GmbH
Spitalstrasse 22
79539 Lörrach
Germany
Elara Pharmaservices Limited
5 Garden Court
Lockington Hall, Main Street
Lockington, Derby
DE74 2RH
United Kingdom.
This leaflet was last revised in 05/2026.
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