Patient leaflet - Trazodone Hydrochloride 150 mg film-coated tablets
1. What Trazodone Film-coated Tablets is and what it is used for
Trazodone Film-coated Tablets contain a medicine called trazodone hydrochloride. This belongs to a group of medicines called antidepressants.
Trazodone Film-coated Tablets can be used to treat anxiety and depression.
2. What you need to know before you take Trazodone Film-coated Tablets
Do not take Trazodone Film-coated Tablets
if you are allergic (hypersensitive) to trazodone hydrochloride or any of the other ingredients of this medicine (listed in Section 6). Signs of an allergic reaction can include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
if you have recently had a heart attack
if you are a heavy drinker or are taking sleeping tablets
if you are under 18 years of age.
Warnings and precautions
Talk to your doctor or pharmacist before taking this medicine if you have or have had:
Thoughts of suicide and worsening of your depression or anxiety disorder
If you are depressed and/or have anxiety disorders you can sometimes have thoughts of harming or killing yourself. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer.
You may be more likely to think like this:
if you have previously had thoughts about killing or harming yourself if you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant.
If you have thoughts of harming or killing yourself at any time, contact your doctor or go to hospital straight away.
You may find it helpful to talk to a relative or close friend that you are depressed or have an anxiety disorder, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour.
Trazodone Film-coated Tablets should not be used in children and adolescents under 18 years of age.
If you are elderly, you may be more prone to side effects, increased caution is necessary especially when taking other medicines at the same time as Trazodone or if you have some other diseases.
Check with your doctor or pharmacist before taking this medicine:
if you have or have ever had fits or seizures (epilepsy)
if you have severe liver, kidney or heart problems
if you are pregnant, trying to become pregnant or are breast-feeding if you have an overactive thyroid gland (hyperthyroidism)
if you have problems passing water or need to pass water (urine) frequently if you have narrow angle glaucoma (an eye disorder)
if you have schizophrenia or other type of mental disorder
if you are elderly, as you may be more prone to side effects are taking buprenorphine (a strong pain killer). The use of buprenorphine with Trazodone Film-coated Tablets can lead to serotonin syndrome, a potentially life-threatening condition (see “Other medicines and Trazodone Film-coated Tablets”)
If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking this medicine.
Other medicines and Trazodone Film-coated Tablets
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because Trazodone Film-coated Tablets can affect the way some other medicines work. Also some medicines can affect the way Trazodone Film-coated Tablets work.
Tell your doctor if you are taking any of the following medicines:
MAOI (MonoAmine Oxidase Inhibitors) medicines such as tranylcypromine, phenelzine and isocarboxazid (for depression) or selegiline (for Parkinson’s disease), or have taken them in the last 2 weeks
other antidepressants, (such as amitriptyline or fluoxetine) Buprenorphine/opioids. These medicines may interact with Trazodone Film-coated Tablets and you may experience symptoms such as involuntary, rhythmic contractions of muscles, including the muscles that control movement of the eye, agitation, hallucinations, coma, excessive sweating, tremor, exaggeration of reflexes, increased muscle tension, body temperature above 38°C. Contact your doctor when experiencing such symptoms sedatives (such as tranquilizers or sleeping pills)
medicines used to treat epilepsy such as carbamazepine and phenytoin medicines used to treat high blood pressure, for example, clonidine digoxin (used to treat heart problems)
medicines used to treat fungal infections such as ketoconazole and itraconazole
some medicines use to treat HIV such as ritonavir and indinavir erythromycin, an antibiotic, used to treat infections
levodopa (used to treat Parkinson’s disease)
St. John’s Wort (a herbal remedy)
warfarin (used to stop your blood from clotting)
Anaesthetics
If you are going to have an anaesthetic (for an operation), tell your doctor or dentist that you are taking this medicine.
Trazodone Film-coated Tablets with food, drink and alcohol
You should avoid drinking alcohol while taking this medicine.
Pregnancy and breast-feeding and fertility
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Trazodone Film-coated Tablets should only be taken during pregnancy if your doctor tells you that treatment with Trazodone Film-coated Tablets is essential for you and tells you to take this medicine.
Taking this medicine in the late stages of pregnancy may lead to your baby experiencing withdrawal symptoms when they are born.
If you are breast-feeding or planning to breast-feed, talk to your doctor or pharmacist before taking any medicine.
Driving and using machines
Trazodone Film-coated Tablets may make you feel sleepy or dizzy. If this happens do not drive or use any tools or machines
Trazodone Film-coated Tablets contains lactose and sodium
If you have been told that you have an intolerance to some sugars, contact your doctor before taking this medicine.
This medicine contains less than 1 mmol sodium (23mg) per tablet, that is to say essentially ‘sodium-free’
3. How to take Trazodone Film-coated Tablets
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Your doctor will decide on the most appropriate dose depending on your illness.
Adults:
Depression
Adults usually start by taking 150mg each day
Your doctor may increase the dose to 300mg each day depending on your condition
For adults in hospital the dose may be as high as 600mg each day. Anxiety
Adults usually start by taking 75mg each day. The tablet can be divided into equal doses. Each half tablet contains 75mg of trazodone hydrochloride Your doctor may increase the dose to 300mg each day.
Elderly
Older people or those who are frail will usually be given a starting dose of 100mg each day.
For lower doses the product is also available as 50mg and 100mg capsules and tablets.
Children and adolescents
This medicine should not be given to children and adolescents under 18 years old. When taking this medicine
Take this medicine by mouth
Swallow the tablet whole with a drink of water
(continued overleaf) PACKAGE LEAFLET: INFORMATION FOR THE USER
Trazodone hydrochloride 150mg Film-coated Tablets
As stated in design Package leaflet
TBA
TW259791 (launch)
UK
All
NA
TBA
9 pts (Reg text)
TW259517 22/06/2026 11/08/2026
Black C
& TW280091 (BROMI) It is recommended to take this medicine either as divided doses with or after food with the major portion of a divided dose taken at bedtime or taken as a single dose at bedtime. This can help lower the chances of side effects If you have been told to take this medicine only once a day then you should take it before going to bed
If you feel the effect of your medicine is too weak or strong, do not change the dose yourself, but ask your doctor.
If you take more Trazodone Film-coated Tablets than you should
If you take more than you should, tell a doctor or go to an accident and emergency department straight away. Take the medicine pack with you. This is so the doctor knows what you have taken.
The following effects may happen: feeling sick or being sick, feeling sleepy, dizzy or faint, fits (seizures), confusion breathing or heart problems.
If you forget to take Trazodone Film-coated Tablets
If you forget to take a dose, take your dose as soon as you remember. If it is almost time for the next dose, skip that dose and take the next one when it is due. Do not take a double dose to make up for a forgotten dose.
If you stop taking Trazodone Film-coated Tablets
Keep taking this medicine until your doctor tells you to stop. Do not stop taking your medicine just because you feel better. When your doctor tells you to stop taking these tablets, he/she will help you to stop taking them gradually. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Stop taking Trazodone Film-coated Tablets and see a doctor or go to a hospital straight away if:
you get swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty swallowing or breathing, itching of the skin and nettle rash. This may mean you are having an allergic reaction to Trazodone Film-coated Tablets painful erection of the penis, unrelated to sexual activity, that will not go away (priapism)
yellowing of the eyes or skin. This could be a liver problem (such as jaundice) getting infections more easily than usual. This could be because of a blood disorder (agranulocytosis)
bruising more easily than usual. This could be because of a blood disorder (thrombocytopenia)
you have severe abdominal pain and bloating, are being sick (vomiting) and have constipation. These may be signs that your intestine is not working properly (paralytic ilius)
Talk to your doctor straight away if you notice the following side effects:
you have thoughts of harming or killing yourself
feeling tired, faint, dizzy, having pale skin. These could be signs of anaemia convulsions/fits
unusual skin sensations such as numbness, tingling, pricking, bumping or creeping of the skin (paraesthesia)
feeling confused, restless, sweating, shaking, shivering, hallucinations (strange vision or sounds), sudden jerks of the muscles or a fast heartbeat, you may have something called Serotonin syndrome
feeling very unwell, possibly with shortness of breath (dyspnoea), difficulty in walking or walking with a shuffling gait, shaking, uncontrolled muscle twitching and a high temperature (above 38°C). This could be a rare condition known as Neuroleptic Malignant Syndrome
rapid, slow or irregular heartbeat.
Below is a list of other side effects that have been reported:
feeling drowsy or sleepy, tiredness
feeling less alert than usual
feeling sick (nausea) or being sick (vomiting), indigestion
constipation, diarrhoea
dry mouth, altered taste, increased amounts of saliva, blocked nose sweating more than usual
dizziness, headache, confusion, weakness, tremor (shaking) blurred vision
loss of appetite and weight loss
feeling dizzy or light-headed on standing or sitting up quickly (postural hypotension), fainting (syncope)
feeling restless and having difficulty sleeping
water retention which may cause swollen arms or legs
skin rash, itching
chest pain
pain in limbs, back pain, pain in your muscles, pain in your joints jerking movements that you cannot control, mainly in the arms and legs uncontrolled muscle movements or twitches
frequent infections with high temperature, severe chills, sore throat or mouth ulcers. These could be signs of a blood problem called leucopenia feeling anxious or more nervous than usual, feeling agitated
overactive behaviour or thoughts (mania), believing things that are not true (delusions), memory disturbance
nightmares
decreased sex drive
feeling dizzy, possibly with a “spinning” feeling (vertigo)
high blood pressure
high temperature
flu type symptoms
difficulty with speaking
higher than normal number of white blood cells (seen by a blood test) high levels of liver enzymes in your blood (shown by a blood test) severe liver disorders such as hepatitis
liver failure with potentially fatal outcome
feeling tired, weak and confused, having muscles that ache, are stiff or do not work well. There may also be headache, loss of appetite, nausea or vomiting, convulsion. This may be due to low sodium levels in your blood. Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
5. How to store Trazodone Film-coated Tablets
Keep this medicine out of the sight and reach of children.
This medicinal product does not require any special storage conditions. Do not use this medicine after the expiry date which is stated on the blister and carton. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Trazodone Film-coated Tablets contains
The active substance is trazodone hydrochloride. Each tablet contains 150mg of trazodone hydrochloride.
The other ingredients are lactose monohydrate, maize starch, povidone, calcium hydrogen phosphate, microcrystalline cellulose, sodium starch glycolate, magnesium stearate and Opadry II pink (polyvinyl alcohol, macrogol 400 talc, red iron oxide (E172) and titanium dioxide (E171)).
What Trazodone Film-coated Tablets looks like and contents of the pack
Trazodone Film-coated tablets are light pink, 11.0mm round film-coated tablets with a break line on one side and plain on the other side.
Trazodone Film-coated Tablets are available in blister packs of 10, 28, 30, 56, 84 and 100 tablets.
Not all pack sizes may be marketed
Marketing Authorisation Holder
Tillomed Laboratories Limited
220 Butterfield, Great Marlings
Luton, LU2 8DL, United Kingdom
Manufacturer
Manx Healthcare Ltd
Unit 2, Bosworth Avenue, Tournament Fields, Warwick, CV34 6UQ UK Other formats
To request a copy of this leaflet in Braille, large print or audio please call 0800 970 6115.
This leaflet was last revised in March 2026
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