TRANYLCYPROMINE 10 MG TABLETS, PARNATE 10 MG TABLETS - patient leaflet, side effects, dosage

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Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

Keep this leaflet. You may need to read it again.

If you have any further questions, ask your doctor or pharmacist.

This medicine has been prescribed for you only. Do not pass it on to others.

It may harm them, even if their signs of illness are the same as yours.

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Tranylcypromine 10mg Tablets will be referred to as Tranylcypromine Tablets throughout this leaflet.

What is in this leaflet:

• 1. What Tranylcypromine Tablets are and what they are used for

• 2. What you need to know before you take Tranylcypromine Tablets

• 3. How to take Tranylcypromine Tablets

• 4. Possible side effects

• 5. How to store Tranylcypromine Tablets

• 6. Contents of the pack and other information

1. WHAT TRANYLCYPROMINE TABLETS ARE AND WHAT THEY ARE USED FOR

Tranylcypromine Tablets contains the active substance tranylcypromine which belongs to a group of antidepressant medicines known as monoamine oxidase inhibitors (MAOIs). It works by stopping the breakdown of two substances in the brain called serotonin and noradrenaline. Your medicine should help bring these substances back to normal levels.

This medicine is used to treat moderate to severe depression in adults. It can also help you if you are having feelings of fear (phobia) which sometimes occurs in depression. This medicine is often used when other types of antidepressant medicines have not worked.

Do not take Tranylcypromine Tablets if:

• you are allergic to tranylcypromine or any of the other ingredients of this medicine (listed in section 6)
• you are taking other MAOIs or have taken other MAOIs within the last two weeks
• you have taken clomipramine or imipramine within the last three weeks or are planning to take them within the next three weeks
• you suffer from porphyria (which is an inherited disease affecting the nervous system and skin)
• you have severe heart disease or any disease of the blood vessels of the brain
• you have pheochromocytoma which is a tumour of the adrenal glands (glands near the kidneys) causing high blood pressure
• you have been diagnosed with an overactive thyroid gland (a gland in the neck)
• you have known liver damage or a disorder affecting the blood cells (your doctor will know)
• you are taking any of the medicines listed under ‘Do not take’ in the “Other Medicines and Tranylcypromine Tablets” section of this leaflet
• please tell your doctor if any of the above apply to you, and do not take Tranylcypromine Tablets.

Warnings and precautions

Talk to your doctor or pharmacist before taking this medicine if you:

• are elderly
• have a mild heart problem which restricts your activity
• suffer from seizures/fits (epilepsy)
• are due to have surgery in the next few weeks
• have a history of dependence on drugs or alcohol.

Even though some of the above may be obvious, it is important that your doctor is aware if any of them apply to you.

Thoughts of suicide and worsening of your depression or anxiety disorder:

If you are depressed and/or have anxiety disorders, you can sometimes have thoughts of harming or killing yourself (see section 4 ‘Possible side effects’). These

28059937 may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer.

You may be more likely to think like this if you:

• have previously had thoughts about killing or harming yourself.
• are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in adults aged less than 25 years with psychiatric conditions who were treated with an antidepressant. —

If you have thoughts of harming or killing yourself, at = any time, contact your doctor or go to a hospital — straight away. You may find it helpful to tell a relative = or close friend that you are depressed or have an s anxiety disorder, and ask them to read this leaflet. You z= might ask them to tell you if they think your = depression or anxiety is getting worse, or if they are S worried about changes in your behavior.

Children and adolescents

Tranylcypromine Tablets is not recommended for children under 18 years old (see section 3 ‘Use in children and adolescents’).

Other medicines and Tranylcypromine Tablets

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.

DO NOT take Tranylcypromine Tablets with the following medicines:

• medicines called sympathomimetic agents – these include ephedrine, pseudoephedrine, adrenaline and noradrenaline (these may be found in medicines used to treat heart problems and asthma as well as some decongestants and cough/cold remedies)
• bupropion, a medicine to help you stop smoking
• medicines to control appetite, e.g. amphetamine and fenfluramine
• medicines that treat Parkinson’s di­sease, e.g. levodopa
• dopamine, a medicine used to treat certain heart conditions
• the pain killers pethidine and nefopam
• general anaesthetics such as propofol, which are used in surgery
• other medicines used to treat depression (e.g. amitriptyline, imipramine, tryptophan)
• buspirone, used to treat anxiety
• metrizamide, used as a nonionic radiopaque contrast agent.

Tranylcypromine Tablets must be taken with caution if you are taking the following medicines:

• other MAOIs such as isocarboxazid
• strong pain killers e.g. codeine
• medicines to treat seizures/fits, e.g. carbamazepine
• barbiturates used to treat severe sleeping problems, e.g. amylobarbitone
• SSRIs such as fluoxetine or sertraline (for depression). Taking your medicine with these products may cause the following serious side effects: sweating, extreme agitation, confusion, muscle stiffness
• medicines for high blood pressure (e.g. guanethidine, reserpine, methyldopa)
• medicines to treat diabetes (e.g. insulin, metformin) antihistamines used to treat allergies, e.g. cetirizine. Consult your doctor before you take Tranylcypromine Tablets if you are taking or might be taking any of these.

Tranylcypromine Tablets with food, drink and alcohol

You should NOT take alcohol (especially red wine) whilst you are taking Tranylcypromine Tablets. This includes non-alcoholic beer or lager.

Tranylcypromine Tablets stops the breakdown of a substance called tyramine which is found in large amounts of certain foods. If this substance is not broken down, it can cause very high blood pressure. So, whilst you are taking Tranylcypromine Tablets, you should avoid the following foods:

• matured cheeses (e.g. cheddar or processed cheese made from mature cheese)
• yeast extracts (e.g. Bovril or Marmite)
• meat, fish or poultry which is not fresh or has been pickled
• broad bean pods
• banana skins.

Pregnancy, breast feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Tranylcypromine Tablets should NOT be used during pregnancy or breast feeding unless your doctor thinks it is essential. This medicine may pass into breast milk.

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