Patient leaflet - Trangina XL 60 mg tablets
1 What Trangina XL tablets are and what they are used for
Isosorbide Mononitrate belongs to a group of medicines called nitrate vasodilators. These work by relaxing the blood vessels of the heart, reducing the strain on the heart making it easier to pump blood.
Trangina XL tablets may be used to:
- prevent angina pectoris (chest pain).
2 What you need to know before you take Trangina XL tablets
Do not take Trangina XL tablets if you:
are allergic to isosorbide mononitrate, isosorbide dinitrate, other nitrates or any of the ingredients in the tablet (see section 6).
An allergic reaction may include a rash, itching or difficulty breathing
- have ever had a stroke
- have very low blood pressure
- have severe anaemia
- have a heart problem called cardiomyopathy or pericarditis or you have narrow heart valves
- are taking medicines called Phosphodiesterase Type 5 Inhibitors, used for male impotence, e.g. sildenafil, tadalafil or vardenafil (also see section: Other medicines and Trangina XL tablets).
Warnings and precautions
Talk to your doctor or pharmacist before taking Trangina XL tablets if you:
- have ever had any serious damage to your heart, such as heart attack or operation.
Other medicines and Trangina XL tablets
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Especially:
- sildenafil , tadalafil and vardenafil (medicines called Phosphodiesterase Type 5 Inhibitors), used to treat male erection dysfunction, should not be taken if taking nitrate preparations such as Isosorbide Mononitrate tablets because a severe and possibly dangerous fall in blood pressure can occur. This would result in collapse, unconsciousness and could be fatal.
Pregnancy, breastfeeding and fertility
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, talk to your doctor or pharmacist before taking this medicine.
Driving and using machines
Trangina XL tablets may make you feel dizzy. Make sure you are not affected before you drive or operate machinery.
Trangina XL tablets contain lactose
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.
If you see another doctor or go into hospital, let them know what medicines you are taking.
Date Sent:
Technologist:
Technically Approved
JDE No.:
50991164 BBBA8316
Continued top of next column
3 How to take Trangina XL tablets
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
You must not take Trangina XL tablets for a sudden attack of angina. If you have a sudden attack, take a glyceryl nitrate tablet.
Swallow the tablets whole with water. Do not crush or chew them.
The recommended dose is:
Adults - one tablet in the morning, the dose may be increased to two tablets (120mg) in the morning. To reduce the possibility of headaches you may initially be given half a tablet (30mg) once daily for the first 2-4 days.
Children - not recommended.
Elderly patients with low blood pressure or liver or kidney disease - your doctor may prescribe you a smaller dose.
If you take more Trangina XL tablets than you should
If you (or someone else) swallows a lot of tablets at the same time, or you think a child may have swallowed any; contact your nearest hospital casualty department or tell your doctor immediately. Symptoms of an overdose include: pulsing headache, excitation, flushing, cold sweat, feeling or being sick, feeling of dizziness or spinning, fainting, fast heartbeat, a fall in blood pressure.
If you forget to take Trangina XL tablets
Do not take a double dose to make up for a forgotten dose. If you forget to take a dose, take it as soon as you remember it and then take the next dose at the right time.
If you stop taking Trangina XL tablets Do not stop taking the tablets without talking to your doctor and follow their advice.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4 Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Common (may affect up to 1 in 10 people)
- Low blood pressure. This may make you feel faint or dizzy
- Faster heartbeat
- Headache
- Feeling dizzy
Feeling sick (nausea)
Uncommon (may affect up to 1 in 100 people)
- Being sick (vomiting)
- Diarrhoea
Rare (may affect up to 1 in 1,000 people)
- Fainting
- Rash
- Itchy skin
Very rare (may affect up to 1 in 10,000 people)
- Pain in muscles
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
5 How to store Trangina XL tablets
Keep this medicine out of the sight and reach of children.
Do not store above 25°C.
Do not take this medicine after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6 Contents of the pack and other information
What Trangina XL tablets contain
- The active substance is isosorbide mononitrate. Each tablet contains 60mg of the active ingredient.
The other ingredients are lactose, hypromellose (E464), glyceryl
palmitostearate, maize starch, magnesium stearate.
What Trangina XL tablets look like and contents of the pack
Trangina XL tablets are white, oval shaped prolonged release tablets impressed “C” on one face and the identifying letters “CY” on either side of a central division line on the reverse.
Pack sizes are 28 tablets
Marketing Authorisation holder and manufacturer
Accord, Barnstaple, EX32 8NS, UK
This leaflet was last revised in June 2020