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SODIUM BICARBONATE INJECTION 8.4%W/V - Patient leaflet, side effects, dosage

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Sources: Original (products.mhra.gov.uk)

Patient leaflet - SODIUM BICARBONATE INJECTION 8.4%W/V

1. what sodium bicarbonate injection is and what it is used for

Sodium Bicarbonate is one of a group of medicines known as alkalinising agents. It is used to correct the acid-alkaline balance in the body.

Sodium bicarbonate is used to reduce the amount of acid in the body after a heart attack in patients who have the following conditions: too much acid in their body or too much potassium in their blood.

It can also be used to treat patients who have taken too much tricyclic antidepressant medicine. Sodium Bicarbonate will only be used after other resuscitation methods have been attempted.

2. what you need to know before you are given sodium bicarbonate injection

You should not be given Sodium Bicarbonate Injection if:

  • you are allergic to Sodium Bicarbonate or any of the other ingredients of this medicine, (listed in section 6)
  • your breathing is slower or more shallow than usual (hypoventilation) you have any blood abnormalities such as high levels of sodium, low levels of calcium, potassium or chloride, or your blood is less acidic than usual (your doctor will need to check this)
  • you have had kidney stones
  • you have high blood pressure
  • you have kidney failure
  • you have heart failure
  • you suffer from fluid retention

If any of the above apply to you or your child please tell your doctor or nurse before you are given Sodium Bicarbonate Injection.

Warnings and precautions

Talk to your doctor, pharmacist or nurse before you are given Sodium Bicarbonate Injection.

Your doctor or nurse may want to regularly check your blood acid levels during the course of treatment with this medicine.

Other medicines and Sodium Bicarbonate Injection

Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.

Including:

  • corticosteroids or corticotropin (medicines used to reduce swelling or to treat hormone problems)
  • medicines used to treat infections (tetracyclines) such as doxycycline
  • quinidine, flecainide (medicines used to treat heart problems)
  • amphetamines (medicines used to treat certain mental disorders and drowsiness)
  • ephedrine and pseudoephedrine (medicines used to treat colds and asthma)
  • potassium supplements
  • medicines used to treat water retention and problems with passing urine such as ethacrynic acid, bumetanide, thiazides or frusemide
  • medicines used to treat high blood pressure (e.g mecamylamine)
  • medicines used to treat Alzheimers disease (e.g. memantine)
  • medicines used to treat diabetes mellitus (e.g. chlorpropamide)
  • medicines used to treat mood disorders (e.g. lithium)
  • Aspirin (Acetylsalicylic acid)

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask you doctor or pharmacist for advice before taking this medicine.

Sodium Bicarbonate Injection contains sodium.

This medicinal product contains 23.00 mg sodium per ml, equivalent to 1.15% of the WHO recommended maximum daily intake of 2g sodium for an adult.

Driving and using machines

This medicine is unlikely to affect your ability to drive or use machines.

  • 3. How Sodium Bicarbonate Injection is given

Your doctor will give you Sodium Bicarbonate injection by slow injection into the vein (intravenous injection).

Your doctor will decide on how much Sodium Bicarbonate injection you should be given.

Adults and the elderly

  • The usual starting dose is 1mmol for every kg you weigh
  • Followed by 0.5 mmol/kg given at 10minute intervals

Children

  • The usual dose is 1 mmol for every kg you weigh given by slow iV injection
  • The medicine should be diluted 1:1 with 5% dextrose for premature infants and new-borns.

If you think you have been given too much Sodium Bicarbonate Injection

As this medicine will be given to you whilst you are in hospital, it is unlikely that you will be given too little or too much. Your doctor has information on how to recognise and treat an overdose. if you are concerned about your treatment please talk to your doctor.

Signs of too much sodium bicarbonate include hyperventilation (over breathing), very sensitive to slight stimuli, twitching and high potassium levels in your blood which may cause you to feel dizzy or tired.

4. possible side effects

Like all medicines, Sodium Bicarbonate injection can cause side effects, although not everybody gets them.

Side effects include:

  • Low levels of potassium causing twitching, muscle weakness, ‘pins and needles’ in the hands or feet, irritability or abnormal heart rhythm
  • Low levels of blood sugar and high concentration of sodium in the blood causing feeling hungry, thirsty, nervous, confused, extreme irritation, increased urination, shakiness or sweating
  • Too much acid in the blood, which many cause an increased rate of breathing ( intracellular acidosis)
  • a blood disorder consisting of an increase in the volume of circulating blood
  • Low levels of calcium causing involuntary contraction of your muscles
  • Swelling due to a build-up of fluid under the skin
  • New born babies may have bleeding inside the skull
  • Sodium bicarbonate may leak out of the veins into the surrounding tissue. This may cause pain,redness or irritation to the skin
  • if the medicine is not correctly injected it could cause the skin to die around the injection site.

5. how to store sodium bicarbonate injection

Keep all medicines out of the sight and reach of children.

This Sodium Bicarbonate injection should not be used after the expiry date which is stated on the carton and ampoule label. The doctor or nurse will check that the expiry date on the label has not been passed before administering the injection to you. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment. This product should only be used in a hospital environment and will be safely disposed of by your doctor.

6. contents of the pack and other information

What Sodium Bicarbonate Injection contains

The active substance is Sodium Bicarbonate 8.4%w/v

The other ingredients are disodium edetate, nitrogen and water for injections.

What Sodium Bicarbonate Injection looks like and contents of the pack

Sodium Bicarbonate injection is a clear, colourless solution supplied in 5ml and 10ml glass ampoules. Each pack contains 10 ampoules.

Marketing Authorisation Holder and Manufacturer Martindale Pharma, Bampton Road, Harold Hill, Romford Essex, RM3 8UG, England

If you would like any more information, or would like the leaflet in a different format, please contact Medical Information at the above address

Product licence number: PL 01883/0023

This leaflet was last revised in August 2018

Martindale |k JL

Pharma fV®

Bampton Road, Harold Hill, Romford, RM3 8UG, United Kingdom

D04221

100mm Measurement Verification Bar

4221-C

Sources: Original (products.mhra.gov.uk)

Frequently Asked Questions

What is Sodium Bicarbonate Injection 8.4% w/v used for?

Sodium Bicarbonate Injection 8.4% w/v is primarily used to treat acidosis, a condition in which the body produces too much acid or when the kidneys cannot remove enough acid from the body.

How does Sodium Bicarbonate Injection work in the body?

It works by neutralizing excess acid in the blood and other fluids, helping to restore normal pH levels.

Can Sodium Bicarbonate Injection be used in children?

Yes, Sodium Bicarbonate can be used in children, but the dosage and administration should be carefully monitored by a healthcare provider.

What are the side effects of Sodium Bicarbonate Injection?

Possible side effects include swelling at the injection site, headache, nausea, and dizziness. If you experience severe side effects or allergic reactions, seek medical attention immediately.

Is it safe to use Sodium Bicarbonate Injection during pregnancy?

Consult your doctor before using this injection if you are pregnant or breastfeeding, as it should only be used if clearly needed.

How is Sodium Bicarbonate Injection administered?

It is usually given through an intravenous (IV) line by a healthcare professional.

Can I use Sodium Bicarbonate Injection at home?

No, this medication should only be administered by a qualified healthcare professional in a clinical setting.

What should I do if I miss a dose of Sodium Bicarbonate Injection?

Since this medication is given in a medical setting, missing a dose will be managed by your healthcare team.

How should Sodium Bicarbonate Injection be stored?

Sodium Bicarbonate Injection should be stored at room temperature away from light and moisture. It should not be frozen.

What interactions should I be aware of with Sodium Bicarbonate Injection?

This injection may interact with certain medications like diuretics and corticosteroids. Always inform your doctor about all medications you are taking.

Is there a specific diet I should follow while receiving Sodium Bicarbonate Injection?

Your doctor may recommend dietary modifications, especially if you have conditions like kidney disease. Follow their advice closely.

When will I feel better after receiving Sodium Bicarbonate Injection?

Improvement can vary based on the individual and underlying condition; some patients may feel better shortly after treatment.

Can I drink alcohol while receiving treatment with Sodium Bicarbonate Injection?

It’s best to avoid alcohol while undergoing treatment; consult your healthcare provider for personal advice.

Will Sodium Bicarbonate Injection affect my blood pressure?

In some cases, it might raise blood pressure temporarily; your healthcare team will monitor this to ensure everything stays in check.

Are there alternatives to Sodium Bicarbonate Injection for acidosis treatment?

Yes, other treatments might include oral bicarbonates or other medications as deemed appropriate by your healthcare provider.

How often will I need Sodium Bicarbonate Injection treatments?

This depends on your specific medical condition; your doctor will create a treatment plan tailored to your needs.

What lab tests will be done while receiving Sodium Bicarbonate Injection?

Your doctor may order blood tests to monitor pH levels and electrolyte balance while you are receiving this medication.

Can I use over-the-counter antacids instead of Sodium Bicarbonate Injection for acidosis?

No, over-the-counter antacids are not suitable substitutes for sodium bicarbonate injection; always follow medical advice for treating acidosis.

Is it normal to feel any discomfort during or after the injection?

Some patients may experience temporary discomfort at the injection site; however, prolonged pain should be reported to your healthcare provider immediately.

Where can I find more information about Sodium Bicarbonate Injection 8.4% w/v?

For more information, consult your pharmacist or healthcare provider for reliable resources tailored to your needs and concerns.