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REFOLINON 15 MG TABLETS - patient leaflet, side effects, dosage

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Sources: Original (products.mhra.gov.uk)

Patient leaflet - REFOLINON 15 MG TABLETS

1. what refolinon is and what it is used for

Refolinon contains the active substance leucovorin calcium which is chemically related to a vitamin called folic acid.

Refolinon increases the levels of folic acid in your body.

Methotrexate (a medicine used to treat cancer) can lower your body’s levels of folic acid. Refolinon is used to reverse this and help to maintain folic acid levels. This is known as ‘leucovorin rescue’.

Refolinon is also used to treat a form of anaemia (megaloblastic) which results from low levels of folic acid.

You should ask your doctor if you are unsure why you have been given Refolinon.

2. what you need to know before you take refolinon

Do not take Refolinon if:

  • you are allergic (hypersensitive) to leucovorin calcium or any of the other ingredients of this medicine (listed in section 6).
  • you have pernicious anaemia or other megaloblastic anaemia where vitamin B12 is deficient.

Other medicines and Refolinon

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.

Some medicines can affect the way Refolinon works, or Refolinon itself can reduce the effectiveness of other medicines taken at the same time.

  • The effectiveness of Refolinon can be reduced by chloramphenicol (an antibiotic).
  • Refolinon can reduce the effectiveness of drugs used to treat epilepsy (phenobarbital, phenytoin or primidone) and lead to more frequent seizures (fits).
  • Refolinon may increase the side effects of fluorouracil (used to treat cancer).

Pregnancy, breast-feeding and fertility Pregnancy

If you are pregnant, think you may be pregnant or planning to have a baby, ask your doctor or pharmacist for advice before you take this medicine.

Breast-feeding

If you are breast-feeding, speak to your doctor who will advise whether you should use an alternative method of feeding your baby.

Driving and using machines

Refolinon is not expected to affect your ability to drive or use machines.

Refolinon contains lactose

Refolinon contains lactose, a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3. how to take refolinon

Always take this medicine exactly as you doctor has told you. You should check with your doctor or pharmacist if you are still not sure.

The usual dose in adults and children is as follows:

The tablets should be swallowed with a glass of water. It is important to take your medicine at the right times.

Refolinon for leucovorin rescue: 15mg (1 tablet) every 6 hours for 48 hours. Refolinon for leucovorin rescue therapy is usually started 24 hours after the start of methotrexate treatment.

Refolinon for megaloblastic anaemia: 15mg (1 tablet) daily until your doctor tells you to stop.

If you take more Refolinon than you should

If you accidentally take too much Refolinon contact your doctor. Side-effects with Refolinon are rare, since it is similar to a naturally occurring vitamin.

If you forget to take Refolinon

If you forget to take a dose, take it as soon as you remember unless it is time for your next dose. Do not take a double dose to make up for a missed dose.

If you stop taking Refolinon

Do not stop taking Refolinon unless your doctor tells you to. If you suddenly stop taking this medicine your condition may return.

If you have any further questions on how to take this medicine, ask your doctor or pharmacist.

4. possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor immediately if you experience any of the following symptoms after taking this medicine. Although they are very rare, these symptoms can be serious.

  • sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips, rash or itching (especially affecting the whole body).

If Refolinon is given with another drug called fluorouracil (to treat cancer) the following side effects have been reported:

  • decreased white blood cell count or low platelets in the blood. Symptoms may include.bruising, nose bleeds or rash. Your doctor will take regular blood tests to check these.
  • sore and inflamed mouth (stomatitis) and/or diarrhoea.

If you have received Refolinon by injection, prior to receiving the tablets, you can also get a high temperature.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:. By reporting side effects, you can help provide more information on the safety of this medicine.

5. how to store refolinon

Keep this medicine out of the sight and reach of children.

Do not use Refolinon after the expiry date which is stated on the carton and label after EXP. The expiry date refers to the last day of that month.

Store below 25 °C. Do not refrigerate or freeze.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

  • 6. Content of the pack and other information

Sources: Original (products.mhra.gov.uk)

Frequently Asked Questions

What is Refolinon 15 mg used for?

Refolinon 15 mg tablets are primarily used to treat certain types of anemia by providing essential folate to your body.

How does Refolinon work in the body?

Refolinon works by supplying folic acid, which is vital for producing healthy red blood cells and supporting overall cell function.

Can I take Refolinon during pregnancy?

Yes, Refolinon is often recommended during pregnancy to prevent folate deficiency, which can affect fetal development.

What should I do if I miss a dose of Refolinon?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.

Are there any common side effects of Refolinon?

Some common side effects of Refolinon might include nausea, loss of appetite, or mild gastrointestinal discomfort.

Is Refolinon suitable for vegetarians?

Yes, Refolinon is generally suitable for vegetarians; however, it's always best to check with your healthcare provider.

How long will I need to take Refolinon?

The duration of treatment with Refolinon will depend on your specific condition and your doctor's recommendations.

Can children take Refolinon 15 mg tablets?

Refolinon can be prescribed for children, but the dosage should be determined by a healthcare professional based on their needs.

What should I avoid while taking Refolinon?

You should avoid excessive alcohol consumption while taking Refolinon, as it can interfere with folic acid absorption.

Can Refolinon interact with other medications?

Yes, some medications may interact with Refolinon. Always inform your doctor about all medications you are currently taking.

Is it safe to take Refolinon long-term?

Long-term use of Refolinon should be monitored by a healthcare provider to prevent potential side effects or complications.

What happens if I overdose on Refolinon 15 mg?

An overdose may lead to serious health issues. If you suspect an overdose, seek medical attention immediately.

Will using Refolinon improve my energy levels?

Refolinon may help improve energy levels associated with low folate levels; however, individual results can vary based on overall health and diet.

Should I take Refolinon with food or on an empty stomach?

Refolinon can be taken with or without food. If it causes stomach upset, try taking it with meals.

Can I drive after taking Refolinon 15 mg tablets?

Generally, there are no specific driving restrictions while taking Refolinon; however, if you feel dizzy or unwell, avoid driving.

Do I need a prescription to buy Refolinon 15 mg?

Yes, in most countries including the US and UK, you will need a prescription from your doctor to obtain Refolinon 15 mg tablets.

What are some natural sources of folate that can complement my treatment with Refolinon?

Natural sources include leafy green vegetables like spinach and kale, legumes such as lentils and chickpeas, and fruits like oranges and bananas.

Can I stop taking Refolinon once I feel better?

You should not stop taking any medication without consulting your healthcare provider first. Follow their advice regarding treatment duration.

Where can I find more information about the safety of using Refolinon during lactation?

Consult your healthcare provider for detailed information about using Refolinon while breastfeeding; they will provide personalized guidance based on your situation.