QUININE SULFATE 300 MG TABLETS - patient leaflet, side effects, dosage

Patient leaflet - QUININE SULFATE 300 MG TABLETS

QUININE SULFATE 200 MG TABLETS

Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you.

Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor, or pharmacist or nurse.
This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.
1. What Quinine Sulfate Tablets are and what they are used for
2. What you need to know before you take Quinine Sulfate Tablets
3. How to take Quinine Sulfate Tablets
4. Possible side effects
5. How to store Quinine Sulfate Tablets
6. Contents of the pack and other information

1. What Quinine Sulfate Tablets are and what they are used for
This medicine belongs to a group of medicines called antiprotozoal agents and they are used to treat: malaria.
and prevent night cramps in adults and the elderly when sleep is regularly disrupted

2. what you need to know before you take quinine sulfate tablets

Do not take this medicine if you:

are allergic to quinine (including that in tonic water and other beverages), quinoline or any of the other ingredients of this medicine (listed in section 6).
have blood in your urine
have ringing in your ears
suffer from muscle weakness (myasthenia gravis)
have problems with your eyes or difficulty seeing
have been told you have a disorder affecting the red blood cells (haemolysis)

Warnings and Precautions

Talk to your doctor or pharmacist before taking this medicine if you:

have irregular heart beats or other heart disease
have had malaria for a long time
suffer from severe glucose-6-phosphate dehydrogenase deficiency (G6PD), this can cause episodes of anaemia after eating certain foods such as fava beans (favism) or take certain drugs including dapsone and drugs to prevent malaria.
were born with or have any condition that causes an abnormal heart rhythm.

You should not take more than the prescribed dose as a condition called ‘cinchonism’ may occur even with normal doses. Please see section 4 ‘Possible side effects’ for symptoms of cinchonism and tell your doctor if you experience any of them.

Other Medicines and Quinine Sulfate Tablets

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Especially:

anticoagulants (to stop your blood from clotting)
cardiac glycosides (for your heart such as digoxin)
chloroquine, mefloquine, artemether with lumefantrine, halofantrine (also to treat malaria)
cimetidine (to treat stomach ulcers or acid reflux and indigestion)
amantadine (to treat Parkinsons Disease or some viral infections)
ciclosporin (to prevent transplant rejection)
flecainide, quinidine or amiodarone (to treat irregular heart beats)
astemizole or terfenadine (for allergic reactions)
pimozide or thioridazine (to treat some mental disorders)
moxifloxacin, rifampicin, or antifungals (to treat infections)
medicines to treat diabetes
suxamethonium (muscle relaxant)
HIV medicines
barbiturates, carbamazepine or phenytoin (used in epilepsy)
Medicines which are known to cause disturbances in heart rhythm
levacetylmethadol (a pain killer).

Pregnancy, breast-feeding and fertility:

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. You should not take quinine sulfate when you are pregnant or breast-feeding, unless the benefits outweigh the risks. This medicine should not be used to treat cramps during pregnancy.

Large doses of quinine can cause foetal abnormalities or induce abortion. You should not breast-feed a baby that might have glucose-6 phosphate dehydrogenase (G6PD) deficiency.

Driving and using machines

Quinine Sulfate tablets may affect your vision and cause vertigo (dizziness or spinning sensation). Make sure you are not affected before you drive or operate machinery.

3. how to take quinine sulfate tablets

Always take this medicine exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist.

Swallow the tablets whole with water.

The recommended dose is:

Malaria (you may be given another medicine for malaria with or after this course of quinine): Adults (including elderly) and children over 12 years of age: 600 mg every eight hours for 5–7 days.

Children aged 10–12 years: 10 mg/kg of bodyweight every eight hours for 7 days.

If you have kidney or liver disease you may be given a different dose.

Children under 10 years: Not recommended.

Night cramps:

Adults (including elderly): 200 mg at bedtime. It may take up to 4 weeks before you notice any reduction in the time of leg cramps.

If you take more Quinine Sulfate Tablets than you should

If you (or someone else) swallow a lot of tablets at the same time, or you think a child may have swallowed any, contact your nearest hospital casualty department or tell your doctor immediately. Symptoms include loss of consciousness, coma, difficulty breathing, changes in heart beat and heart function, kidney failure, fits, ‘ringing’ in the ears, loss of hearing, headache, feeling or being sick, changes in vision, low blood potassium (causing muscle twitching/weakness or abnormal heart rhythm) and low blood sugar and sweating. Some of these side effects can be fatal. High doses of quinine may also cause miscarriage in pregnant women.

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If you forget to take the tablets

Do not take a double dose to make up for a forgotten dose. If you forget to take a dose take it as soon as you remember it and then the next dose at the right time.

If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

4. Possible side effects

Like all medicines, this medicine may cause side effects, although not everybody gets them.

Contact your doctor immediately if the following effects occur:

Not known: frequency cannot be estimated from the available data

allergic reactions -itchy skin rash, Oedema (swelling of the lips, face, throat or tongue) flushing, fever, asthma or sensitivity to light
sores in the mouth, nose, and eyes, a skin rash, blistering (Stevens-Johnson syndrome)
cinchonism -abdominal pain, diarrhoea, disturbed vision (blurred vision, changes in colour perception or field of vision, total blindness), headache, feeling or being sick, ringing in the ears or impaired hearing, rashes, loss of consciousness, fits, shock due to heart problems, irregular heart beats, death. If these occur while taking Quinine Sulfate tablets for leg cramps, treatment should be stopped and a doctor contacted straight away.
changes to blood cells as seen in blood or urine tests. If you notice that you are bruising or bleeding easily, have frequent nose bleeds, or you have more sore throats and infections than usual tell your doctor who may want to give you a blood test.
miscarriages (at very high concentrations)
tightness in chest, difficulty breathing or wheezing

Tell your doctor if you notice any of the following side effects or notice any other effects not listed: