PROPRANOLOL TABLETS BP 40 MG - patient leaflet, side effects, dosage

0 What you need to know before 1 you take Propranolol tablets

Do not take Propranolol tablets and

tell your doctor if you:

• are allergic to Propranolol or any of the other ingredients of this medicine (listed in section 6)
• have untreated/uncon­trolled heart failure or are in shock caused by heart problems
• suffer with heart conduction or rhythm problems (second or third

degree heart block or sick sinus syndrome )

• have a slow heart rate
• have low blood pressure
• suffer from severe blood circulation problems (which may cause your fingers and toes to tingle or turn pale or blue)
• suffer from diabetes mellitus (low blood sugar levels may be hidden by this medicine) or increased acidity of the blood (metabolic acidosis)
• are on a strict fasting diet

• suffer from a tight, painful feeling in the chest in periods of rest (Prinzmetal’s an­gina)
• suffer from asthma or any other breathing difficulties
• suffer from untreated phaeochromocytoma (high blood pressure due to a tumour near the kidney).

Warnings and precautions Talk to your doctor or pharmacist before taking Propranolol tablets if you:

• have heart failure (please also see “Do not take” section above)
• suffer from blood circulation problems (which may cause your fingers and toes to tingle or turn pale or blue)
• have a heart weakness or first degree heart block
• have diabetes. Propranolol may change your normal response to low blood sugar, which usually involves an increase in heart rate. Propranolol may cause low blood sugar levels even in patients who

are not diabetic (please see section 4 “Possible side effects”)

• have kidney or liver problems (including cirrhosis of the liver)
• have thyrotoxicosis. Propranolol may hide the symptoms of thyrotoxicosis
• have a phaeochromocytoma (a tumour near the kidney) (please also see “Do not take” section above)
• have a history of allergic reactions.

Other medicines and Propranolol tablets

• Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Propranolol can interfere with the action of some other medicines and some medicines can have an effect on propranolol tablets. The medicines which can cause some problems when taken together with propranolol tablets are: insulin (to treat diabetes) ergotamine, dihydroergotamine

or rizatriptan (for migraine)

• disopyramide, quinidine, amiodarone, propafenone (to treat irregular heartbeat (arrhythmia))
• digitalis glycosides (digoxin) (to treat heart conditions)
• verapamil, diltiazem, nifedipine, nisoldipine, nicardipine, isradipine, lacidipine and dihydropyridine (to treat heart diseases)
• adrenaline (used in anaphylactic shock)
• lidocaine (to treat irregular —heartbeat or as a local anaesthetic)

• cimetidine (to treat stomach ulcers)
• hydralazine (to treat high blood pressure)
• clonidine (for hypertension or migraine). If you are taking clonidine and propranolol together, you must not stop taking clonidine unless your doctor tells you to do so. If it becomes necessary for you to stop taking clonidine, your doctor will give you careful instructions on how to do it.

• ibuprofen and indometacin (for pain and inflammation)
• chlorpromazine and thioridazine (for psychiatric illness)
• anaesthetics
• warfarin (to thin the blood)
• rifampicin (to treat infection)
• theophylline (treating asthma)

Propranolol tablets with alcohol

You are advised to avoid alcohol whilst taking this medicine.

Pregnancy, breast-feeding and fertility

Propranolol tablets are not recommended during pregnancy or breast-feeding. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

Your medicine is unlikely to affect your ability to drive or to operate

machinery. However, some people may occasionally feel dizzy or tired when taking propranolol tablets. If this happens to you, ask your doctor for advice.

Anaesthetics or tests

If you are going to have an anaesthetic or any blood or urine tests, please tell your doctor or dentist that you are taking Propranolol tablets. If you see another doctor or go into hospital, let them know what medicines you are taking.

Propranolol tablets contain " Lactose

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

Propranolol tablets contain Carmoisine (E122)

Propranolol tablets contain carmoisine (E122) which may cause allergic reactions.

0 How to take Propranolol tablets

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Propranolol tablets should be swallowed with a drink of water, before meals. Your doctor will have decided how many propranolol tablets you need to take each day depending on your condition. Follow your doctor’s instruc­tions about when and how to take your tablets. Please read the label on the

carton. This will also tell you how many tablets to take and when you should take them. Ask your doctor or pharmacist if you are not sure. The following table shows the recommended total daily dosages for an adult:

Hypertension (high blood pressure) 160 mg to 320 mg Angina (chest pains) 120 mg to 240 mg

Arrythmias (disorders of heart rhythm)

30 mg to 160 mg

Protection of the heart after a heart attack

160 mg

Prevention of migraine

80 mg to 160 mg

Essential tremor

80 mg to 160 mg

Anxiety

40 mg to 120 mg

Certain thyroid conditions (such as thyrotoxicosis) 30 mg to 160 mg

Hypertrophic cardiomyopathy

Package leaflet: Information for the patient

Propranolol 40mg Tablets

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.

• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet

□ What Propranolol tablets are and what they are used for HWhat you need to know before you take Propranolol tablets 0How to take Propranolol tablets Q Possible side effects 0 How to store Propranolol I tablets ^Contents of the pack and other information

4| Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop treatment and contact a doctor at once if you have the

£|How to store Propranolol tablets

Keep Propranolol tablets out of the sight and reach of children.

Do not store the tablets above 25°C. Do not take the tablets after the expiry date which is stated on the carton. The expiry date is also stated on the back of the strip after ‘Exp’. Do not throw away any medicines via wastewater or household waste. Ask

^Contents of the pack and other information

What Propranolol tablets contain

• the active substance (the ingredient that makes the tablets work) is propranolol hydrochloride. Each tablet contains either 10mg, 40mg, 80mg or 160mg of the active substance.
• the other ingredients are lactose, magnesium stearate, maize starch, stearic acid, hypromellose (E464).
• the coating contains polysorbate, carmoisine (E122), titanium dioxide (E171), iron oxide red (E172), hypromellose (E464).

What Propranolol tablets look like and contents of the pack

Propranolol tablets 40mg pink film-coated tablets.

Pack sizes are 28, 56 and 1000 tablets.