Patient leaflet - Perindopril 8 mg film-coated tablets
1. What Perindopril Tablets are and what they are used for
The name of your medicine is Perindopril 2 mg or 4 mg or 8 mg Film-coated Tablets. The tablets are available in three strengths. In the rest of this leaflet your medicine is called Perindopril.
Perindopril belongs to a group of medicines called ACE (angiotensin converting enzyme) inhibitors. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Perindopril is used:
- to treat high blood pressure (hypertension),
to treat heart failure (a condition where the heart is unable to pump
enough blood to meet the body’s needs),
to reduce the risk of cardiac events, such as heart attack, in patients
with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked) and who have already had a heart attack and/or an operation to improve the blood supply to the heart by widening the vessels that supply it.
2. What you need to know before you take Perindopril
Do not take Perindopril:
if you are allergic (hypersensitive) to perindopril or any of the other
ACE inhibitors or to any of the other ingredients in the tablets (listed in section 6).
if you have had symptoms such as wheezing, swelling of the face,
tongue or throat, intense itching, skin rashes, fainting or dizziness with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema)
if you are more than 3 months pregnant. (it is also better to avoid
Perindopril in early pregnancy – see section “Pregnancy and breast-feeding”
if you are having dialysis or any other type of blood filtration.
Depending on the machine that is used, Perindopril may not be suitable for you.
if you have diabetes or impaired kidney function and you are treated
with a blood pressure lowering medicine containing aliskiren.
If you have kidney problems where the blood supply to your kidneys is
reduced (renal artery stenosis)
If you are being treated with sacubitril/valsartan, a medicine for heart
failure as the risk of angioedema (rapid swelling under the skin in an area such as the throat) is increased (see “Warnings and Precautions” and “Other medicines and Perindopril”).
Perindopril should not be given to children
If you think any of the above situations applies to you do not take the tablets. Consult your doctor and take his/her advice.
Warnings and precautions:
If any of the following apply to you, please talk to your doctor or pharmacist or nurse before taking perindopril:
if you have narrowing of the main blood vessel leading from the heart
(aortic stenosis) or heart muscle disease (hypertrophic cardiomyopathy) or narrowing of the artery supplying the kidney with blood (renal artery stenosis);
if you have any other heart problems or liver problems or renal
insufficiency (poor function of the kidneys), or if you are receiving dialysis;
if you have abnormally increased levels of a hormone called
aldosterone in your blood (primary aldosteronism);
if you suffer from a collagen vascular disease (disease of the
connective tissue) such as systemic lupus erythematosus or scleroderma;
if you are on a salt restricted diet or use salt substitutes which contain
potassium;
- if you are to undergo anaesthesia and/or major surgery;
- if you suffer from diabetes;
if you are to undergo LDL apheresis (which is removal of cholesterol
from your blood by a machine);
if you are going to have desensitization treatment to reduce the effects
of an allergy to bee or wasp stings;
if you have recently suffered from diarrhoea or vomiting, or are
dehydrated;
if you have been told by your doctor that you have an intolerance to
some sugars;
if you are taking any of the following medicines used to treat high blood
pressure:
a. “an angiotensin II receptor blocker” (ARBs) (also known as sartans
- for example valsartan, telmisartan, Irbesartan), in particular if you have diabetes related kidney problems,
b. aliskiren,
Your doctor may check your kidney function, blood pressure, and the
amount of electrolytes (e.g. potassium) in your blood at regular intervals.
See also information under the heading “Do not take Perindopril”
If you are of black origin since you may have a higher risk of
angioedema and this medicine may be less effective in lowering your blood pressure than in non-black patients;
Are taking any of the following medicines, the risk of angioedema is
increased:
a. racecadotril (used to treat diarrhoea)
b. sirolimus, everolimus, temsirolimus and other drugs belonging to
the class of so-called mTor inhibitors (used to avoid rejection of transplanted organs and for cancer)
c. linagliptin, saxagliptin, sitagliptin, vildagliptin and other drugs
belonging to the class of the also called gliptins (used to treat diabetes)
d. sacubitril (available as fixed-dose combination with valsartan),
used to treat long-term heart failure
Angioedema
Angioedema (a severe allergic reaction with swelling of the face, lips, tongue or throat with difficulty in swallowing or breathing) has been reported in patients treated with ACE inhibitors, including perindopril. This may occur at any time during treatment. If you develop such symptoms, you should stop taking perindopril and see a doctor immediately. See also section 4.
You must tell your doctor if you think you are (or might become) pregnant. Perindopril is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section). Children and adolescents
The use of perindopril in children and adolescents up to the age of 18 years is not recommended.
Other medicines and perindopril
Please tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Treatment with perindopril can be affected by other medicines. Your doctor may need to change your dose and/or take other precautions. These include:
other medicines for treating high blood pressure including angiotensin
II receptor blockers (ARB), aliskiren (see also information under the headings “Do not take Perindopril” and “Warnings and precautions") or diuretics (medicines which increase the amount of urine produced by the kidneys);
potassium-sparing drugs (e.g. triamterene or amiloride); potassium
supplements or potassium-containing salt substitutes, other drugs which can increase potassium in your body (such as heparin, a medicine used to thin blood to prevent clots; trimethoprim and co-trimoxazole also known as trimethoprim/sulfamethoxazole for infections caused by bacteria);
potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5mg to 50mg per
day;
- lithium for mania or depression;
non-steroidal anti-inflammatory drugs (e.g. ibuprofen) for pain relief
or high dose aspirin;
medicines for the treatment of diabetes (insulin or tablets such as
metformin) to lower blood sugar;
baclofen (used to treat muscle stiffness in diseases such as multiple
sclerosis);
medicines for the treatment of mental disorders such as depression,
anxiety, schizophrenia or other psychoses; (e.g. tricyclic antidepressants, antipsychotics),
immunosuppressants (medicines which reduce the defence
mechanism of the body) used for the treatment of auto-immune disorders (e.g. rheumatoid arthritis) or following transplant surgery (e.g. ciclosporin, tacrolimus);
- trimethoprim (for the treatment of infections);
- estramustine (used in cancer therapy);
medicines, which are most often used to treat diarrhoea (racecadotril)
or avoid rejection of transplanted organs (sirolimus, everolimus, temsirolimus and other drugs belonging to the class of so-called mTor inhibitors). See section “Warnings and precautions”);
sacubitril/valsartan (used to treat long-term heart failure). See sections
“Do not take Perindopril” and “Warnings and precautions”;
- allopurinol used for the treatment of gout;
- procainamide, a treatment for irregular heartbeat;
vasodilators including nitrates (products that make the blood vessels
become wider);
medicines used for the treatment of low blood pressure, shock or
asthma (e.g. ephedrine, noradrenaline or adrenaline);
Gold salts, especially with intravenous administration (used to treat
symptoms of rheumatoid arthritis).
Ask your doctor if you are not sure what these medicines are. If you go into hospital, let the medical staff know you are taking perindopril. Perindopril with food and drink
It is preferable/recommended that Perindopril should be taken before a meal.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking any medicine
Pregnancy
You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Perindopril before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Perindopril. Perindopril is not recommended in early pregnancy and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage.
Breastfeeding
Tell your doctor if you are breast-feeding or about to start breast-feeding. Perindopril is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is new-born, or was born prematurely. Driving and using machines
Perindopril usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in certain patients. If you are affected in this way, your ability to drive or to operate machinery may be impaired. Do not drive or use machinery if you experience dizziness or weariness while taking Perindopril. If this occurs, you should talk to your doctor. Information about ingredients
Sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.
Mannitol
This medicine contains mannitol and may have a mild laxative effect. Lecithin (Soya)
This medicine contains soya. If you are allergic to peanut or soya, do not take this medicinal product.
3. How to take Perindopril
Always take Perindopril exactly as your doctor or pharmacist has told you. You should check with your doctor or pharmacist if you are not sure. Swallow your tablets with a glass of water, preferably at the same time each day, in the morning, before a meal. Your doctor will decide on the right starting dose for you and on any increase in the dose depending on your condition and whether you are taking any other medicines. Method of administration:
The recommended dosages for Perindopril Tablets are as follows: High blood pressure:
Adults: the usual starting and maintenance dose for treatment is 4 mg
once a day. After a month, this can be increased (if required) to 8 mg a day which is the maximum recommended dose.
Elderly (65 years or over): the usual starting dose is 2 mg once a day.
After a month, this can be increased to 4 mg a day and then if necessary to 8 mg a day.
Heart failure:
Adults & the elderly: treatment should be started under close medical
supervision with 2 mg once a day. After two weeks, it can be increased to 4 mg once a day which is the maximum recommended dose for heart failure.
Stable coronary artery disease:
Adults: the usual starting dose is 4 mg once daily. After two weeks and
if 4 mg is well tolerated, this can be increased to 8 mg once daily which is the maximum recommended dose in this indication.
Elderly (65 years or over): the usual starting dose is 2 mg once daily.
After one week, this can be increased to 4 mg once daily and after a further week to 8 mg once daily.
Use in children and adolescents
Perindopril Tablets are not suitable for use in children and adolescents. If you take more Perindopril than you should
If you take too many tablets, contact your nearest hospital accident and emergency department or tell your doctor immediately. The most likely effect of an overdose is low blood pressure which can make you feel faint or dizzy. If this happens, laying down on your back with your legs raised can help.
If you forget to take Perindopril
It is important to take your medicine as your doctor has told you as regular treatment works better. However, if you forget to take one or more doses, take the next dose at the usual time and then carry on as normal. Do not take a double dose to make up for a dose which you forgot. If you stop taking Perindopril
The taking of perindopril is usually life-long; you should discuss with your doctor before you stop taking your medicine.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist or nurse.
4. POSSIBLE SIDE EFFECTS
Like all medicines, perindopril can cause side effects, although not everybody gets them. Do not be alarmed by the list below, you may not get any of them.
Stop taking your tablets at once and TELL YOUR DOCTOR IMMEDIATELY if you experience any of the following side effects that can be serious:
swelling of the face, lips, mouth, tongue or throat difficulty in breathing
(angioedema) (see section 2 “Warnings and precautions”) (Uncommon – may affect up to 1 in 100 people),
severe dizziness or fainting due to low blood pressure (Common – may
affect up to 1 in 10 people),
unusual fast or irregular heartbeat, chest pain (angina) or heart attack
(very rare – may affect up to 1 in 10,000 people),
weakness of arms or legs, or problems speaking which could be sign
of a possible stroke (Very rare – may affect up to 1 in 10,000 people),
sudden wheeziness, chest pain, shortness of breath, or difficulty in
breathing (bronchospasm) (Uncommon – may affect up to 1 in 100 people),
inflamed pancreas which may cause severe abdominal and back pain
accompanied with feeling very unwell (Very rare- may affect up to 1 in 10,000 people);
yellowing of the skin or eyes (jaundice) which could be a sign of
hepatitis (Very rare – may affect up to 1 in 10,000 people),
skin rash which often starts with red itchy patches on your face, arms
or legs (erythema multiforme) (Very rare – may affect up to 1 in 10,000 people).
Tell your doctor if you notice any of the following side effects:
- Common (may affect up to 1 in 10 people)
- Headache
- Dizziness
- Vertigo
- Pins and needles
- Vision disturbances
- Tinnitus (sensation of noises in the ears)
- cough,
- shortness of breath (dyspnoea),
gastrointestinal disorders (nausea, vomiting, abdominal pain,
changes in your sense of taste, feeling of indigestion, diarrhoea, constipation)
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- allergic reactions (such as skin rashes, itching)
- muscle cramps
- feeling of weakness
- Uncommon (may affect up to 1 in 100 people)
- changes in mood or sleep disturbances
- dry mouth
- intense itching or severe skin rashes,
- formation of blister clusters over the skin,
- Renal insufficiency (poor function of the kidneys)
- impotence
- sweating
- excess of eosinophils (a type of white blood cells),
- somnolence
- fainting
- palpitations
- tachycardia
- vasculitis (inflammation of blood vessels),
- photosensitivity reaction (increased sensitivity of the skin to sun),
- arthralgia (joint pain),
- myalgia (muscle pain),
- chest pain,
- malaise,
- oedema peripheral,
- fever,
- fall,
- change in laboratory parameters: high blood level of potassium reversible on discontinuation, low level of sodium, hypoglycaemia (very low blood sugar level) in case of diabetic patients, increased blood urea, and increased blood creatinine,
- Depression.
Rare (may affect up to 1 in 1000 people):
- psoriasis worsening,
- changes in laboratory parameters: increased level of liver enzymes, high level of serum bilirubin,
- Dark urine, feeling sick (nausea) or being sick (vomiting), muscle cramps, confusion and seizures. These may be symptoms of a condition called SIADH (inappropriate antidiuretic hormone secretion),
- Decreased or absent urine output,
- Flushing,
- acute renal failure (kidney failure).
- Very rare (may affect up to 1 in 10,000 people)
- confusion
- rare type of pneumonia called eosinophilic pneumonia
- blocked up or runny nose (rhinitis)
- changes in blood values such as a lower number of white and red blood cells, lower haemoglobin, lower number of blood platelets. If you have these symptoms contact your doctors as soon as possible.
- Frequency not known (cannot be estimated from available data):
- Discoloration, numbness and pain in fingers or toes (Raynaud’s phenomenon)
Reporting of side effects:
If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in Google Play or Apple App store.
By reporting side effects, you can help provide more information on the safety of this medicine.
5. HOW TO STORE PERINDOPRIL
Keep this medicine out of the sight and reach of children. Do not use Perindopril after the expiry date which is stated on the carton after “Exp”. The expiry date refers to the last day of that month. Store in original package in order to protect from moisture. Store below 30°C.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6. CONTENTS OF THE PACK AND OTHER INFORMATION
What Perindopril Tablets contain
The active substance is Perindopril Erbumine.
Each tablet contains 2, 4 or 8 mg of Perindopril Erbumine. The other ingredients are:
- Tablet core: mannitol (E421), sodium starch glycolate (Type A), sodium carbonate anhydrous, hypromellose (HPMC E-15), macrogol-6000, talc, simeticone, magnesium stearate.
Tablet coating: hypromellose 6cps, polyvinyl alcohol, titanium dioxide
(E171), talc, lecithin (Soya), xanthan gum.
What Perindopril tablets look like and contents of the pack
Perindopril 2 mg tablets are white to off-white circular, biconvex film coated tablets plain on both sides.
Perindopril 4 mg tablets are white to off-white, barrel shaped, biconvex film coated tablets, debossed with ‘PE4’ on one side and a central score line on the other. The score line is only to enable a tablet to be broken in half for ease of swallowing, and not to divide into equal doses. Perindopril 8 mg tablets are white to off-white, barrel shaped, biconvex film coated tablets, debossed with ‘PE8’ on one side and a central score line on the other. The score line is only to enable a tablet to be broken in half for ease of swallowing, and not to divide into equal doses. The tablets are supplied in blister packs (Aluminium laminated foil) of 7, 10, 14, 15, 20, 28, 30, 50, 56, 60, 90, 100, 112, 120, 500 tablets per pack. Not all pack sizes may be marketed.
Marketing Authorisation Holder and manufacturer
Torrent Pharma (UK) Ltd.
3rd Floor, Nexus Building,
4 Gatwick Road, Crawley,
West Sussex, RH10 9BG,
United Kingdom
This leaflet was last revised in September 2025.
8103718-7803