Patient leaflet - Nebivolol 2.5 mg tablets
1. What Nebivolol is and what it is used for
Nebivolol tablets contain nebivolol, a cardiovascular drug belonging to the group of selective beta-blocking agents (i.e. with a selective action on the cardiovascular system). It prevents increased heart rate, controls heart pumping strength. It also exerts a dilating action on blood vessels, which contributes as well to lower blood pressure.
It is used to treat raised blood pressure (hypertension).
Nebivolol are also used to treat mild and moderate chronic heart failure in patients aged 70 or over, in addition to other therapies.
2. What you need to know before you take Nebivolol
Do not take Nebivolol
if you are allergic to nebivolol or any of the other ingredients of this medicine (listed in section
6),
if you have one or more of the following disorders:
- low blood pressure
- serious circulation problems in the arms or legs
- very slow heartbeat (less than 60 beats per minute)
certain heart conduction disorders (2nd and 3rd degree heart block – AV block [without
pacemaker])
sick sinus syndrome (a certain type of disturbance in heart rhythm) including sino-arterial
block (SA block)
heart failure, which has just occurred or which has recently become worse, or you are
receiving treatment for circulatory shock due to acute heart failure by intravenous drip feed to help your heart work
- asthma or wheezing (now or in the past)
untreated phaeochromocytoma, a tumour located on top of the kidneys (in the adrenal
glands)
- liver function disorder
- a metabolic disorder (metabolic acidosis), for example, diabetic ketoacidosis. Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking Nebivolol.
Inform your doctor if you have or develop one of the following problems:
- abnormally slow heartbeat
- a type of chest pain due to spontaneously occurring heart cramp called Prinzmetal angina
- untreated chronic heart failure
- 1st degree heart block (a kind of light heart conduction disorder that affects heart rhythm)
poor circulation in the arms or legs, e.g. Raynaud’s disease or syndrome, cramp-like pains when
walking
- prolonged breathing problems
diabetes: this medicine has no effect on blood sugar, but it could conceal the warning signs
of a low sugar level (e.g. palpitations, fast heartbeat) and could increase the risk of severe hypoglycaemia when used with certain type of antidiabetic drugs called sulfonylureas (e.g. gliquidone, gliclazide, glibenclamide, glipizide, glimepiride or tolbutamide).
overactive thyroid gland: this medicine may mask the signs of an abnormally fast heart rate due
to this condition
allergy: this medicine may intensify your reaction to pollen or other substances you are allergic
to
- psoriasis (a skin disease - scaly pink patches) or if you have ever had psoriasis
if you have to have surgery, always inform your anaesthetist that you are on Nebivolol before
being anaesthetised.
If you have serious kidney problems do not take Nebivolol for heart failure and tell your doctor. You will be regularly monitored at the beginning of your treatment for chronic heart failure by an experienced physician (see section 3). This treatment should not be stopped abruptly unless clearly indicated and evaluated by your doctor (see section 3).
Children and adolescents
Because of the lack of data on the use of the product in children and adolescents, Nebivolol are not recommended for use in them.
Other medicines and Nebivolol
Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.
Always tell your doctor if you are using or receiving any of the following medicines in addition to Nebivolol:
Medicines for controlling the blood pressure or medicines for heart problems (such as
amiodarone, amlodipine, cibenzoline, clonidine, digoxin, diltiazem, disopyramide, felodipine, flecainide, guanfacin, hydroquinidine, lacidipine, lidocaine, methyldopa, mexiletine, moxonidine, nicardipine, nifedipine, nimodipine, nitrendipine, propafenone, quinidine, rilmenidine, verapamil).
Sedatives and therapies for psychosis (a mental illness) e.g. barbiturates (also used for
epilepsy), phenothiazine (also used for vomiting and nausea) and thioridazine.
- Medicines for depression e.g. amitriptyline, paroxetine, fluoxetine.
Medicines for asthma, blocked nose or certain eye disorders such as glaucoma (increased
pressure in the eye) or dilation (widening) of the pupil.
Baclofen (an antispasmodic drug); Amifostine (a protective medicine used during cancer
treatment).
- Medicines used for anaesthesia during an operation.
- Medicines for diabetes such as insulin or oral antidiabetic drugs
All these medicines as well as nebivolol may influence the blood pressure and/or heart function.
Medicines for treating excessive stomach acid or ulcers (antacid drug): you should take
Nebivolol during a meal and the antacid medicine between meals.
Nebivolol with food and drink
Please refer to section 3.
Pregnancy and breast-feeding
Beta-blockers, including nebivolol, can affect pregnancy and may harm the unborn baby. They can reduce blood flow to the placenta, which may lead to slower growth, miscarriage, premature birth or death of the foetus during pregnancy. Nebivolol should not be used during pregnancy, unless clearly necessary
If nebivolol is required during pregnancy, close monitoring is required. After birth, your baby needs to be monitored for signs of low blood sugar (hypoglycaemia) and slow heart rate (bradycardia), which can occur within the first three days of life.
It is not recommended for use while breast-feeding.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before taking any medicine.
Driving and using machines
This medicine may cause dizziness or fatigue. If affected, do not drive or operate machinery. Nebivolol contains lactose
This product contains lactose. Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malapsorption should not take this medicinal product. Nebivolol contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’.
3. How to take Nebivolol
Always take this medicine exactly as your doctor has told you. Check with your doctor, pharmacist or nurse if you are not sure.
Nebivolol may be taken before, during or after the meal, but, alternatively, you can take it independently of meals. The tablet is best taken with some water.
Treatment of raised blood pressure (hypertension)
The recommended dose is 5 mg of nebivolol once a day. The dose should be taken preferably at
the same time of the day.
Older patients and patients with a kidney disorder will usually start with 2.5 mg of nebivolol
daily.
The therapeutic effect on blood pressure becomes evident after 1-2 weeks of treatment.
Occasionally, the optimal effect is reached only after 4 weeks.
Treatment of chronic heart failure
- Your treatment will be started and closely supervised by an experienced physician.
- Your doctor will start your treatment with 1.25 mg per day. This may be increased after 1-2 weeks to 2.5 mg per day, then to 5 mg per day and then to 10 mg per day until the correct dose is reached for you. Your doctor will prescribe the dose that is right for you at each step and you should closely follow his/her instructions.
- The maximum recommended dose is 10 mg a day.
- You will need to be under the close supervision for 2 hours by an experienced physician when you start treatment and every time your dose is increased.
- Your doctor may reduce your dose if necessary.
- You should not stop treatment abruptly as this can make your heart failure worse.
- Patients with serious kidney problems should not take this medicine.
- Take your medicine once daily, preferably at about the same time of day.
- Your doctor may decide to combine Nebivolol with other medicines to treat your condition.
- Do not use in children or adolescents
If you take more Nebivolol than you should
If you accidentally take an overdose of this medicine, tell your doctor, pharmacist or nurse immediately. The most frequent symptoms and signs of a Nebivolol Tablet overdose are very slow heart beat (bradycardia), low blood pressure with possible fainting (hypotension), breathlessness such as in asthma (bronchospasm), and acute heart failure. You can take activated charcoal (which is available at your pharmacy) while you wait for the arrival of the doctor.
If you forget to take Nebivolol
If you forget a dose of Nebivolol, but remember a little later on that you should have taken it, take that day’s dose as usual. However, if a long delay has occurred (e.g. several hours), so that the next due dose is near, skip the forgotten dose and take the next, scheduled, normal dose at the usual time. Do not take a double dose to make up for a forgotten dose. Repeated skipping, however, should be avoided.
If you stop taking Nebivolol
You should always consult with your doctor before stopping Nebivolol Tablet treatment, whether you are taking it for high blood pressure or chronic heart failure.
You should not stop Nebivolol treatment abruptly as this can temporarily make your heart failure worse. If it is necessary to stop Nebivolol treatment for chronic heart failure, the daily dose should be decreased gradually, by halving the dose, at weekly intervals.
If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking Nebivolol and seek medical help immediately if you have any of the following reactions:
- Swelling of the face, lips, tongue and/or throat, which may cause difficulty in breathing and swallowing (angioedema), severe itching of the skin (with raised lumps). Frequency not known (cannot be estimated from the available data).
When Nebivolol is used for the treatment of raised blood pressure, the possible side effects are: Common side effects (may affect up to 1 in 10 people)
- headache,
- dizziness
- an unusual itching or tingling feeling
- shortness of breath
- constipation
- nausea
- diarrhoea
- tiredness
- swollen hands or feet.
Uncommon side effects (may affect up to 1 in 100 people)
- nightmares,
- feelings of depression
- abnormal vision
- slow heartbeat or other heart complaints
- low blood pressure
- cramp-like leg pains on walking
- breathlessness such as in asthma, due to sudden cramps in the muscles around the airways(bronchospasm)
- digestive difficulties (dyspepsia)
- gas in stomach or bowel
- skin rash
- itchiness
- impotence
- vomiting
Very rare side effects (may affect up to 1 in 10,000 people)
- fainting (syncope),
- worsening of psoriasis (a skin disease – scaly pink patches).
The following side effects have been reported only in some isolated cases during Nebivolol treatment:
- whole-body allergic reactions, with generalised skin eruption (hypersensitivity reactions);
- rapid-onset swelling, especially around the lips, eyes, or of the tongue with possible sudden difficulty breathing (angioedema);
kind of skin rash notable for pale red, raised, itchy bumps of allergic or non allergic causes
(urticaria).
When Nebivolol are used for chronic heart failure, the following side effects: were seen: Very common side effects (may affect more than 1 in 10 people)
- dizziness,
- slow heartbeat
Common side effects (may affect up to 1 in 10 people)
- worsening of heart failure
- low blood pressure (such as feeling faint when getting up quickly)
- inability to tolerate this medicine
- a kind of light heart conduction disorder that affects heart rhythm (1st degree AV-block)
- swelling of the lower limbs (such as swollen ankles).
Reporting of side effects
If you get any side effect, talk to your doctor. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow card Scheme at website: www.mhra.gov. uk/yellowcard or search for MHRA Yellow card in the Google Play or Apple App store. By reporting side effects you can help provide more information on the safety of this medicine.
5. How to store Nebivolol
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and the blister foil after EXP. The expiry date refers to the last day of that month.
This medicinal product does not require any special storage conditions.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
6. Contents of the pack and other information
What Nebivolol contains
- The active substance is nebivolol.
Each tablet contains 2.5 mg of nebivolol (as nebivolol hydrochloride).
The other ingredients are: Lactose monohydrate, Maize Starch, Croscarmellose Sodium,
Hypromellose, Silica, colloidal anhydrous, Cellulose, Microcrystalline, Indigo carmine (E132), Magnesium Stearate
What Nebivolol looks like and contents of the pack
Nebivolol 2.5 mg Tablets are available as Light Blue coloured with dark blue spots, round, uncoated tablets, plain on both sides having approximate diameter of 5 mm.
Nebivolol 2.5 mg Tablets are available in OPA/Al/PVC//Al blisters placed into cardboard boxes containing 7, 14, 28, 56, 84 and 98 tablets.
Not all pack sizes may be marketed.
Marketing Authorisation Holder and Manufacturer
Torrent Pharma (UK) Ltd.
3rd Floor, Nexus Building
4 Gatwick Road
Crawley
West Sussex
RH10 9BG
United Kingdom
This leaflet was last revised in 09/2026.
8114161-7803
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