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Naseptin nasal cream – patient leaflet, side effects, dosage

Last updated: · Text from the MHRA, as of · About this document

Medicine status: Prescription only (POM) Details

Medicine strength:
1 mg/gram + 5 mg/gram
Contains active substances:

Patient leaflet - Naseptin nasal cream

1. What Naseptin is and what it is used for

Naseptin contains an antibiotic and a disinfectant.

Naseptin is used to treat and prevent infections in the nose.

Naseptin works by killing certain bacteria that cause infections.

2. What you need to know before you use Naseptin

Do not use Naseptin:

  • if you are allergic (hypersensitive) to chlorhexidine dihydrochloride, neomycin sulfate or any of the other ingredients of

    this medicine (listed in Section 6).

Warnings and precautions

Talk to your doctor or pharmacist before using Naseptin.

If you have hearing problems, it is important that you speak to your doctor before using Naseptin. Naseptin could make your hearing worse.

Also, before you use Naseptin, tell your doctor if:

  • you are elderly
  • the patient is a child.

If any of the above applies to you, or if you are not sure, speak to your doctor or pharmacist before you use Naseptin. Do not use Naseptin immediately after washing your face

If Naseptin is mixed with certain soaps, it may not work properly.

Avoid getting Naseptin onto your clothes or other fabrics

If this happens, do not use bleach to remove it, as brown stains may develop.

Other medicines and Naseptin

Please tell your doctor or pharmacist if you are taking or have recently taken/used any other medicines, including medicines obtained without a prescription.

Pregnancy and breast-feeding

Naseptin is unlikely to have any effect on your unborn baby or on breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine.

Important information about some of the ingredients of Naseptin

This product contains cetostearyl alcohol which may cause local skin reactions, for example contact dermatitis.

3. How to use Naseptin

Always use Naseptin exactly as your doctor has told you to. You should check with your doctor or pharmacist if you are not sure. Place a small amount of the cream on the tip of your little finger and carefully apply inside one nostril. Repeat for the other nostril. Preventing infections

Use Naseptin twice a day to prevent infection.

Treating infections

Use Naseptin 4 times a day to treat infection. Treatment is usually for 10 days.

The amount you should use is the same for children, adults and the elderly.

Naseptin is only to be used inside your nose. Do not use it in your eyes or ears.

If you take more Naseptin than you should

If you accidentally use too much cream, or someone else uses or swallows any of the cream, you should tell your doctor at once or contact your nearest accident and emergency department. Show any left-over cream or the empty container to the doctor. If you forget to use Naseptin

If you forget to apply a dose, apply it as soon as possible, unless it is almost time to apply the next dose. Then go on as before. Do not apply a double dose.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

4. Possible side effects

Do not worry. Like all medicines, Naseptin can cause side effects, although not everyone gets them. Naseptin sometimes causes the following side effects in some people:

Tell your doctor or contact your nearest hospital straight away if you notice or suspect any of the following symptoms. You may need urgent medical treatment.

  • Signs of a severe allergic reaction such as:

    • swelling of the face, tongue or throat
    • difficulty breathing
    • dizziness
    • severe irritation, reddening or blistering of your skin.

Other possible side effects include:

  • irritation of the skin
  • hearing problems
  • kidney problems (pain when you pass water, blood in your urine)
  • if you use Naseptin for a long time, it may cause allergic skin reactions (redness or itching) • temporary loss of your sense of smell or taste
  • change of skin colour at the application site.

If they are severe or last for more than a few days, tell your doctor.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist.

This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

5. How to store Naseptin

Keep this medicine out of the sight and reach of children.

Do not use Naseptin after the expiry date which is stated on the tube. The expiry date refers to the last day of that month. Do not store Naseptin above 25°C. Keep the tube tightly closed.

Do not use Naseptin if you notice a change in the colour or feel of the cream.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist on how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

What Naseptin contains

The active ingredients in this medicine are chlorhexidine dihydrochloride 0.1% w/w and neomycin sulfate 0.5% w/w. The other ingredients are medium-chain triglycerides, cetostearyl alcohol/ethylene oxide condensate, cetostearyl alcohol and water.

What Naseptin looks like and contents of the pack

Naseptin is a smooth, white cream.

Naseptin comes in aluminium tubes of 15g (grams).

Marketing Authorisation Holder and Manufacturer

The product licence holder is: Alliance Pharmaceuticals Limited, Avonbridge House, Chippenham, Wiltshire, SN15 2BB, UK. Naseptin is manufactured by: FAMAR A.V.E. Avlon Plant, 49th km National Road Athens - Lamia, Avlona Attiki, 19011, Greece. The information in this leaflet applies only to Naseptin. If you have any questions or you are not sure about anything, ask your doctor or a pharmacist.

This leaflet was last revised in: November 2024.

Naseptin is a registered trademark of Alliance Pharmaceuticals Limited.

Alliance and associated devices are registered trademarks of Alliance Pharmaceuticals Limited. © Alliance Pharmaceuticals Limited 2024.

150mm

About this document

Source: MHRA - Medicines and Healthcare products Regulatory Agency (products.mhra.gov.uk) · Marketing authorisation: PL 16853/0024

Last revision stated in the text: November 2024 · MHRA data as of 13 October 2026

Found a mistake? Tell us on the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Facts about Naseptin nasal cream

Prescription needed? Yes, prescription-only medicine (POM)
Active substances Neomycin, Chlorhexidine
Strength 1 mg/gram + 5 mg/gram
Pharmaceutical form Nasal cream
How is it taken Nasal
Excipients Medium-chain triglycerides, cetostearyl alcohol, cetostearyl alcohol/ethylene oxide condensate, purified water.
Pack sizes 15 gram
Is it available? Listed as available (NHS Dictionary of Medicines and Devices – not a record of current supplies)
Storage Store below 25°C.
Drug group (ATC) Other antibiotics for topical use
Marketing authorisation PL 16853/0024 (first authorised 10 January 2007)
Marketing authorisation holder Alliance Pharmaceuticals Ltd
Codes GTIN 5036631009575 · BNF 12020300

Sources: the MHRA product information (products.mhra.gov.uk) and the NHS Dictionary of Medicines and Devices (dm+d), release 10.1.0 of 12 October 2026, NHS Business Services Authority. Contains public sector information licensed under the Open Government Licence v3.0.