2. What you need to know before you use Minitran patches

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Driving and using machines

Minitran patches may make you feel dizzy and faint when you stand up. If this happens to you, do not drive or use machinery.

• You are taking Viagra (sildenafil) for

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What is in this leaflet:

• 1. What Minitran patches are and what they are used for

• 2. What you need to know before you use Minitran patches

• 3. How to use Minitran patches

• 4. Possible side effects

• 5. How to store Minitran patches

• 6. Contents of the pack and other information

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Minitran patches contain the active substance -glyceryl Trinitrate and betonglo Tgroup of-medicines called vasodilators which work by widening blood vessels. This helps blood । which is carrying oxygen reach the muscle in your heart.

When you apply a Minitran patch to your | skin the medicine passes through your skin. and into your bloodstream.

Minitran patches are used to help prevent angina attacks (chest pains). Minitran patches | may be used on their own, or with other treat-. ments for angina prescribed by your doctor.

The Minitran 5 mg patch is also used by doctors and nurses to keep veins open and । improve blood flow when you are given a drip (intravenous infusion).

If you have angina it is important that you I receive effective treatment. If angina is left । untreated the muscle in your heart can become starved of oxygen and this could cause a potentially fatal heart attack । (myocardial infarction).

This could make you unconscious and may be fatal

• Other vasodilators such as nitrates, hydralazine or minoxidil (used to treat high blood pressure and angina)
• Medicines used to lower blood pressure such as beta-blockers, ACE inhibitors and diuretics (water tablets)
• Medicines to treat depression such as amitriptyline and dothiepin
• Medicines to treat psychiatric illnesses such as neuroleptics
• Medicines to treat pain, fever and inflammation such as aspirin or any other non-steroidal anti-inflammatory drug
• Dihydroergotamine, a medicine used to treat migraines
• Any other medicine, including medicines obtained without a prescription.
• Riociguat a medicine used to treat some types of hypertension.

These medicines can interfere with how well your treatment works.

Using Minitran patches with food and drink

Do not drink alcohol whilst using Minitran patches as this can cause your blood pressure to drop. This may make you feel dizzy or faint.

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
• In this leaflet, Minitran 5 mg, 10 mg or

15 mg transdermal patches will be called Minitran patches.

potentially fatal drop in blood pressure can occur if these two medicines are used together

• You are allergic to glyceryl trinitrate or any of the other ingredients in Minitran patches (see Section 6)
• You have severe anaemia
• You have glaucoma (high pressure in your eye) or you have been told that you have high pressure inside the skull
• You have heart valve disease or percarditis (inflammation of the lining of the heart)
• You have an angina attack. Your doctor will

spray for this

• Severe hypotension (systolic blood pressure less than 90 mmHg)
• Severe hypovolemia
• You are taking Riociguat a medicine used to treat some types of hypertension.

If any of the above apply to you, talk to your doctor or pharmacist.

Children and adolescents

Minitran patches are not recommended for use in children.

Check with your doctor before using _Miniiran_pat­chesJf: _____

• You suffer from any heart or lung problems. Minitran patches may have to be used under your doctor’s super­vision
• You are pregnant, or are trying to become pregnant.

Other medicines and Minitran patches

Tell your doctor if you are taking any of the following medicines:

• Medicines for failure to achieve an erection such as Viagra. Using Minitran with these medicines could cause a severe drop in your blood pressure.

Always use Minitran patches exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

The usual starting dose is one Minitran 5 mg patch per day.Your doctor or pharmacist will have chosen the strength which best suits your condition. You should check with your doctor or pharmacist if you are unsure.

Remember: Each Minitran patch is contained in a sealed pouch. The sticky side of the patch is covered by a disposable liner before the patch is applied to your skin.

How many patches to use

Normally one patch per day is sufficient.

When to apply the patches i

• At the start of your treatment, put on a patch in the morning i
• Remove the patch before you go to bed.

You should have 8 to 12 hours without a 1 patch on. This will prevent you from becom- [ ing tolerant to the medicine and will ensure i the treatment remains effective

• Each morning put on a new patch

~ You" calTkeep the"patch inplace wITTTst — i-bathing, showering or swimming.

How and where to apply the patch

• Choose a smooth area of skin to apply the patch. The area should be hairless to ensure good contact of the patch with the skin. The chest, upper arm or shoulders are suitable
• Your hands and the skin where you will apply the patch should be clean and dry.

Do not use powder or moisturiser.

2.75”

2.75”

2.75”

0.25”

8.25” W x 15.5” H leaflet, Front

ARTWORK TEMPLATE DRAWING – 12 NOV 2015

Die Line

Fold Line

No Copy I Copy Area

(0.125” Land R, 0.25” T and B)

Registration

3M ID Number:

• – 3M ID Number is 11 digits.

• – 3M ID Number placeholder (XX-XXXX-XXXX-X) will be replaced with the actual 3M ID Number.

• – 3M ID Number can be moved to the end of the customer’s copy, if desired.

  15.

  
  

3M Manufacturing Bar Code:

• – BC Human Readable place holder (X’s), shown below the 3M Manufacturing Bar Code with leading “0” (zero), is to be replaced by 3M ID Number with leading “0”, and is to be 6pt. Arial or Helvetica, and must fit in the BC Human Readable area.

• – BC Human Readable area is 1” W x 0.125” H, and is directly below the 3M Manufacturing Bar Code.

• – 3M designated print supplier will front fill the bar code with leading “0” (zero) to complete the 12 digit number to be encoded.

• – Bar code is 1” W x 0.438” H.

• – Bar code area is 1.5” W x 0.938” H (0.25” QZ L, R;

0.188 QZ T, B), and includes the bar code, the bar code quiet zones, and the BC Human Readable area.

• – No copy other than the bar code or BC Human Readable in the bar code area.

• – The bar code area is centered in the panel, and as the bar code reads, the top of the bar code is flush to the third fold.

NOTE: THE BAR CODE, BC HUMAN READABLE, AND 3M ID NUMBER PRINT BLACK.

4. Possible side effects

2.5”

2.5”

2.5”

5. How to store Minitran patches

Keep this medicine out of the sight and reach of children.

Do not use Minitran patches after the expiry date on the sachet. The expiry date refers to the last day of that month. Store Minitran patches at room temperature (below 25 °C) in a dry place. Do not expose to light.

The shelf life for Minitran patches is three years.

“Do not throwrawayany­medicines' via"waste-water or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6. Contents of the pack and other information

2.5”

2.5”

2.5”

2.75”

2.75”

2.75”

0.25”

8.25” W x 15.5” H leaflet, Front

ARTWORK TEMPLATE DRAWING – 12 NOV 2015

Die Line

Fold Line

No Copy I Copy Area

(0.125” Land R, 0.25” T and B)

Registration

3M ID Number:

• – 3M ID Number is 11 digits.

• – 3M ID Number placeholder (XX-XXXX-XXXX-X) will be replaced with the actual 3M ID Number.

• – 3M ID Number can be moved to the end of the customer’s copy, if desired.

  15.

  
  

3M Manufacturing Bar Code:

• – BC Human Readable place holder (X’s), shown below the 3M Manufacturing Bar Code with leading “0” (zero), is to be replaced by 3M ID Number with leading “0”, and is to be 6pt. Arial or Helvetica, and must fit in the BC Human Readable area.

• – BC Human Readable area is 1” W x 0.125” H, and is directly below the 3M Manufacturing Bar Code.

• – 3M designated print supplier will front fill the bar code with leading “0” (zero) to complete the 12 digit number to be encoded.

• – Bar code is 1” W x 0.438” H.

• – Bar code area is 1.5” W x 0.938” H (0.25” QZ L, R;

0.188 QZ T, B), and includes the bar code, the bar code quiet zones, and the BC Human Readable area.

• – No copy other than the bar code or BC Human Readable in the bar code area.

• – The bar code area is centered in the panel, and as the bar code reads, the top of the bar code is flush to the third fold.

NOTE: THE BAR CODE, BC HUMAN READABLE, AND 3M ID NUMBER PRINT BLACK.

Die Line

----Fold Line

; No Copy I Copy Area

! (0.125” Land R, 0.25” T and B)

Registration

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