Patient leaflet - LEVETIRACETAM BRISTOL LAB 500 MG FILM-COATED TABLETS

What is in this leaflet:

1. What Levetiracetam is and what it is used for
2. What you need to know before you take Levetiracetam
3. How to take Levetiracetam
4. Possible side effects
5. How to store Levetiracetam
6. Contents of the pack and other information

1. what levetiracetam is and what it is used for

Levetiracetam is an antiepileptic medicine (a medicine used to treat seizures in epilepsy).

Levetiracetam is used:

on its own in adults and adolescents from 16 years of age with newly diagnosed epilepsy, to treat a certain form of epilepsy. Epilepsy is a condition where the patients have repeated fits (seizures). Levetiracetam is used for the epilepsy form in which the fits initially affect only one side of the brain, but could thereafter extend to larger areas on both sides of the brain (partial onset seizure with or without secondary generalisation). Levetiracetam has been given to you by your doctor to reduce the number of fits.
as an add-on to other antiepileptic medicines to treat:
partial onset seizures with or without generalisation in adults, adolescents, children and infants from one month of age;
myoclonic seizures (short, shock-like jerks of a muscle or group of muscles) in adults and adolescents from 12 years of age with juvenile myoclonic epilepsy;
primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic generalised epilepsy (the type of epilepsy that is thought to have a genetic cause).

2. what you need to know before you take levetiracetam

Do not take Levetiracetam:

if you are allergic to levetiracetam, pyrrolidone derivatives or any of the other ingredients of this medicine (listed in section 6)

Warnings and precautions

Talk to your doctor before taking Levetiracetam

if you suffer from kidney problems, follow your doctor's instructions. He/she may decide if your dose should be adjusted.
If you notice any slow down in the growth or unexpected puberty development of your child, please contact your doctor
A small number of people being treated with antiepileptics such as levetiracetam have had thoughts of harming or killing themselves. If you have any symptoms of depression and/or suicidal ideation, please contact your doctor. If you have a family or medical history of irregular heart rhythm (visible on an electrocardiogram), or if you have a disease and/or take a treatment that make(s) you prone to heartbeat irregularities or salt imbalances.

Tell your doctor or pharmacist if any of the following side effects gets serious or last longer than a few days:

Abnormal thoughts, feeling irritable or reacting more aggressively than usually, or if you or your family and friends notice important changes in mood or behaviour.

Aggravation of epilepsy:

Your seizures may rarely become worse or happen more often, mainly during the first month after the start of the treatment or increase of the dose. If you experience any of these new symptoms while taking Levetiracetam, see a doctor as soon as possible.

Children and adolescents

Levetiracetam is not indicated in children and adolescents below 16 years on its own (monotherapy).

Other medicines and Levetiracetam

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Do not take macrogol (a drug used as laxative) for one hour before and one hour after taking levetiracetam as this may results in a loss of its effect.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

Levetiracetam can be used during pregnancy, only if after careful assessment it is considered necessary by your doctor.

You should not stop your treatment without discussing this with your doctor.

Levetiracetam should not be used during pregnancy unless clearly necessary. A risk of birth defects for your unborn child cannot be completely excluded.

Breast-feeding is not recommended during treatment.

Driving and using machines

Levetiracetam may impair your ability to drive or operate any tools or machinery, as it may make you feel sleepy. This is more likely at the beginning of treatment or after an increase in the dose. You should not drive or use machines until it is established that your ability to perform such activities is not affected.

Levetiracetam 750mg contains Sunset Yellow FCF (E110)

Sunset yellow FCF (E110 colouring agent), which may cause allergic reactions.

Information on sodium content

This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‚sodium free‘.

| 3. How to take Levetiracetam |

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Take the number of tablets following your doctor's instructions.

Levetiracetam must be taken twice a day, once in the morning and once in the evening, at about the same time each day.

250mg and 750mg tablets: The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.

500mg and 1000mg tablets: The tablets can be divided into equal halves

Adjunctive Therapy and monotherapy (from 16 years of age)

Adults (>18 years) and adolescents (12 to 17 years) weighing 50 kg or more:

General dose: between 1000 mg and 3,000 mg each day.

When you will first start taking Levetiracetam, your doctor will prescribe you a lower dose during 2 weeks before giving you the lowest general dose.

Example: if your daily dose is intended to be 1000 mg, your reduced starting dose is 1 tablet of 250 mg in the morning and 1 tablet of 250 mg in the evening, and the dose will be gradually incremented to reach 1000 mg daily after 2 weeks.

Adolescents (12 to 17 years) weighing 50 kg or less:

Your doctor will prescribe the most appropriate pharmaceutical form of Levetiracetam according to weight and dose.

Dose in infants (1 month to 23 months) and children (2 to 11 years) weighing less than 50 kg:

Your doctor will prescribe the most appropriate pharmaceutical form of Levetiracetam according to the age, weight and dose.

Levetiracetam 100 mg/ml oral solution is a formulation more appropriate to infants and children under the age of 6 years and to children and adolescent (from 6 to 17 years) weighing less than 50 kg and when tablets don't allow accurate dosage.

Method of administration tablets:

Swallow Levetiracetam with a sufficient quantity of liquid (e.g. a glass of water). You may take levetiracetam with or without food.

After oral administration the bitter taste of levetiracetam may be experienced.

Duration of treatment:

Levetiracetam is used as a chronic treatment. You should continue levetiracetam treatment for as long as your doctor has told you.
Do not stop your treatment without your doctor's advice as this could increase your seizures.

If you take more Levetiracetam than you should:

The possible side effects of an overdose of levetiracetam are sleepiness, agitation, aggression, decrease of alertness, inhibition of breathing and coma.

Contact your doctor if you took more tablets than you should. Your doctor will establish the best possible treatment of overdose.

If you forget to take Levetiracetam:

Contact your doctor if you have missed one or more doses.

Do not take a double dose to make up for a forgotten dose.

If you stop taking Levetiracetam:

If stopping treatment, Levetiracetam should be discontinued gradually to avoid an increase of seizures. Should your doctor decide to stop your Levetiracetam treatment, he/she will instruct you about the gradual withdrawal of Levetiracetam.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

| 4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor immediately, or go to your nearest emergency department, if you experience:

weakness, feel light-headed or dizzy or have difficulty

breathing, as these may be signs of a serious allergic (anaphylactic) reaction

swelling of the face, lips, tongue and throat (Quincke's oedema)
flu-like symptoms and a rash on the face followed by an extended rash with a high temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes (Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS])
symptoms such as low urine volume, tiredness, nausea, vomiting, confusion and swelling in the legs, ankles or feet, as this may be a sign of sudden decrease of kidney function
a skin rash which may form blisters and look like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) (erythema multiforme)
a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome)
a more severe form of rash causing skin peeling in more than 30% of the body surface (toxic epidermal necrolysis)
signs of serious mental changes or if someone around you notices signs of confusion, somnolence (sleepiness), amnesia (loss of memory), memory impairment (forgetfulness), abnormal behaviour or other neurological signs including involuntary or uncontrolled movements. These could be symptoms of an encephalopathy.

The most frequently reported side effects are nasopharyngitis, somnolence (sleepiness), headache, fatigue and dizziness. At the beginning of the treatment or at dose increase side effects like sleepiness, tiredness and dizziness may be more common. These effects should however decrease over time.

Very common: may affect more than 1 in 10 people

nasopharyngitis
somnolence (sleepiness); headache

Common: may affect up to 1 in 10 people

anorexia (loss of appetite)
depression, hostility or aggression, anxiety, insomnia, nervousness or irritability
convulsion, balance disorder (equilibrium disorder), dizziness (sensation of unsteadiness), lethargy (lack of energy and enthusiasm), tremor (involuntary trembling)
vertigo (sensation of rotation)
cough
abdominal pain, diarrhoea, dyspepsia (indigestion), vomiting, nausea
rash
asthenia/fatigue (tiredness).

Uncommon: may affect up to 1 in 100 people

decreased number of blood platelets, decreased number of white blood cells
weight decrease, weight increase
suicide attempt and suicidal ideation, mental disorder, abnormal behaviour, hallucination, anger, confusion, panic attack, emotional instability/mood swings, agitation
amnesia (loss of memory), memory impairment (forgetfulness), abnormal coordination/ataxia (impaired coordinated movements), paraesthesia (tingling), disturbance in attention (loss of concentration)
diplopia (double vision), vision blurred;
elevated/abnormal values in a liver function test
hair loss, eczema, pruritus
muscle weakness, myalgia (muscle pain)
injury.

Rare: may affect up to 1 in 1,000 people

infection
decreased number of all blood cell types
severe allergic reactions (DRESS, anaphylactic reaction [severe and important allergic reaction], Quincke's oedema [swelling of the face, lips, tongue and throat])
decreased blood sodium concentration
suicide, personality disorders (behavioural problems), thinking abnormal (slow thinking, unable to concentrate)
delirium;
encephalopathy (see sub-section „Tell your doctor immediately“ for a detailed description of symptoms);
uncontrollable muscle spasms affecting the head, torso and limbs, difficulty in controlling movements, hyperkinesia (hyperactivity)
pancreatitis
liver failure, hepatitis
sudden decrease in kidney function
skin rash, which may form blisters and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) (erythema multiforme), a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens Johnson syndrome), and a more severe form causing skin peeling in more than 30% of the body surface (toxic epidermal necrolysis).
rhabdomyolysis (breakdown of muscle tissue) and associated blood creatine phosphokinase increase. Prevalence is significantly higher in Japanese patients when compared to non-Japanese patients.
seizures may become worse or happen more often;
change of the heart rhythm (Electrocardiogram);
limp or difficulty walking.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme website ' or search for MHRA Yellow Card in the Google Play or Apple App Store.' By reporting side effects you can help provide more information on the safety of this medicine.

| 5. How to store Levetiracetam |

Keep this medicine out of the sight and reach of children.
This medicinal product does not require any special storage conditions.
Do not use this medicine after the expiry date stated on the carton box and blister after “EXP.” The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment

| 6. Contents of the pack and other information |

What Levetiracetam contains

The active substance is Levetiracetam.

Each 250 mg tablet contains 250 mg Levetiracetam.

Each 500 mg tablet contains 500 mg Levetiracetam.

Each 750 mg tablet contains 750 mg Levetiracetam. Each 1000 mg tablet contains 1000 mg Levetiracetam.

The other ingredients are:

Tablet core:

Maize starch, Croscarmellose sodium, Povidone (kollidon 30), Silica colloidal anhydrous, Talc and Magnesium Stearate.

Tablet coating:

Levetiracetam Bristol Lab 250 mg film-coated tablets:

Talc, Polyvinyl alcohol, Indigo carmine (E132), Macrogol (3350) and Titanium dioxide (E171).

Levetiracetam Bristol Lab 500 mg film-coated tablets: Talc, Polyvinyl alcohol, Yellow Iron Oxide (E172), Macrogol 3350 and Titanium dioxide (E171).

Levetiracetam Bristol Lab 750 mg film-coated tablets: Talc, Polyvinyl alcohol, Sunset yellow FCF (E110), Macrogol (3350) and Titanium dioxide (E171), Iron oxide red (E172).

Levetiracetam Bristol Lab 1000 mg film-coated tablets: Talc, Polyvinyl alcohol, Macrogol (3350) and Titanium dioxide (E171).

What Levetiracetam tablets look like and contents of the pack

Levetiracetam Bristol Lab 250 mg film-coated tablets are blue coloured, oblong shaped, film-coated tablets scored on one side, debossed with “H” on one side and „87“ on other side.

Levetiracetam Bristol Lab 500 mg film-coated tablets are yellow coloured, oblong shaped, film-coated tablets scored on one side, debossed with “H” on one side and “88” on the other side.

Levetiracetam Bristol Lab 750 mg film-coated tablets are orange coloured, oblong shaped, film-coated tablets scored on one side, debossed with “H” on one side and “90” on the other side.

Levetiracetam Bristol Lab 1000 mg film-coated tablets are white coloured, oblong shaped, film-coated tablets scored on one side, debossed with “H” on one side and “91” on the other side.

Levetiracetam is available in the cardboard boxes containing 10, 20, 30, 50, 60, 100 and 200 film-coated tablets.

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Bristol Laboratories Ltd.,

Unit 3, Canalside, Northbridge Road Berkhamsted, Hertfordshire, HP4 1EG, UK

Telephone: 0044 (0) 1442 200922, Fax: 0044 (0) 1442 873717

Email :

Manufacturer

Bristol Laboratories Limited

Laporte Way,

Luton,

LU4 8WL,

United Kingdom

Levetiracetam Bristol Lab 250 mg film-coated tablets; PL 17907/0388

Levetiracetam Bristol Lab 500 mg film-coated tablets; PL 17907/0389

Levetiracetam Bristol Lab 750 mg film-coated tablets; PL 17907/0390

Levetiracetam Bristol Lab 1000 mg film-coated tablets; PL 17907/0391

This leaflet was last revised in November 2021.

What is in this leaflet:

1. What Levetiracetam is and what it is used for
2. What you need to know before you take Levetiracetam
3. How to take Levetiracetam
4. Possible side effects
5. How to store Levetiracetam
6. Contents of the pack and other information

1. what levetiracetam is and what it is used for

Levetiracetam is an antiepileptic medicine (a medicine used to treat seizures in epilepsy).

Levetiracetam is used:

on its own in adults and adolescents from 16 years of age with newly diagnosed epilepsy, to treat a certain form of epilepsy. Epilepsy is a condition where the patients have repeated fits (seizures). Levetiracetam is used for the epilepsy form in which the fits initially affect only one side of the brain, but could thereafter extend to larger areas on both sides of the brain (partial onset seizure with or without secondary generalisation). Levetiracetam has been given to you by your doctor to reduce the number of fits.
as an add-on to other antiepileptic medicines to treat:
partial onset seizures with or without generalisation in adults, adolescents, children and infants from one month of age;
myoclonic seizures (short, shock-like jerks of a muscle or group of muscles) in adults and adolescents from 12 years of age with juvenile myoclonic epilepsy;
primary generalised tonic-clonic seizures (major fits, including loss of consciousness) in adults and adolescents from 12 years of age with idiopathic tgeneralised epilepsy (the type of epilepsy that is ought to have a genetic cause).

2. what you need to know before you take levetiracetam

Do not take Levetiracetam:

if you are allergic to levetiracetam, pyrrolidone derivatives or any of the other ingredients of this medicine (listed in section 6)

Warnings and precautions

Talk to your doctor before taking Levetiracetam

if you suffer from kidney problems, follow your doctor's instructions. He/she may decide if your dose should be adjusted.
If you notice any slow down in the growth or unexpected puberty development of your child, please contact your doctor
A small number of people being treated with antiepileptics such as levetiracetam have had thoughts of harming or killing themselves. If you have any symptoms of depression and/or suicidal ideation, please contact your doctor. If you have a family or medical history of irregular heart rhythm (visible on an electrocardiogram), or if you have a disease and/or take a treatment that make(s) you prone to heartbeat irregularities or salt imbalances.

Tell your doctor or pharmacist if any of the following side effects gets serious or last longer than a few days:

Abnormal thoughts, feeling irritable or reacting more aggressively than usually, or if you or your family and friends notice important changes in mood or behaviour.

Aggravation of epilepsy:

Children and adolescents

Levetiracetam is not indicated in children and adolescents below 16 years on its own (monotherapy).

Other medicines and Levetiracetam

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Do not take macrogol (a drug used as laxative) for one hour before and one hour after taking levetiracetam as this may results in a loss of its effect.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

Levetiracetam can be used during pregnancy, only if after careful assessment it is considered necessary by your doctor.

You should not stop your treatment without discussing this with your doctor.

Levetiracetam should not be used during pregnancy unless clearly necessary. A risk of birth defects for your unborn child cannot be completely excluded.

Breast-feeding is not recommended during treatment.

Driving and using machines

Levetiracetam 750mg contains Sunset Yellow FCF (E110)

Sunset yellow FCF (E110 colouring agent), which may cause allergic reactions.

Information on sodium content

This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‚sodium free‘.

| 3. How to take Levetiracetam |

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Take the number of tablets following your doctor's instructions.

Levetiracetam must be taken twice a day, once in the morning and once in the evening, at about the same time each day.

250mg and 750mg tablets: The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses.

500mg and 1000mg tablets: The tablets can be divided into equal halves

Adjunctive Therapy and monotherapy (from 16 years of age)

Adults (>18 years) and adolescents (12 to 17 years) weighing 50 kg or more:

General dose: between 1000 mg and 3,000 mg each day.

When you will first start taking Levetiracetam, your doctor will prescribe you a lower dose during 2 weeks before giving you the lowest general dose.

Adolescents (12 to 17 years) weighing 50 kg or less:

Your doctor will prescribe the most appropriate pharmaceutical form of Levetiracetam according to weight and dose.

Dose in infants (1 month to 23 months) and children (2 to 11 years) weighing less than 50 kg:

Your doctor will prescribe the most appropriate pharmaceutical form of Levetiracetam according to the age, weight and dose.

Method of administration tablets:

Swallow Levetiracetam with a sufficient quantity of liquid (e.g. a glass of water). You may take levetiracetam with or without food.

After oral administration the bitter taste of levetiracetam may be experienced.

Duration of treatment:

Levetiracetam is used as a chronic treatment. You should continue levetiracetam treatment for as long as your doctor has told you.
Do not stop your treatment without your doctor's advice as this could increase your seizures.

If you take more Levetiracetam than you should:

The possible side effects of an overdose of levetiracetam are sleepiness, agitation, aggression, decrease of alertness, inhibition of breathing and coma.

Contact your doctor if you took more tablets than you should. Your doctor will establish the best possible treatment of overdose.

If you forget to take Levetiracetam:

Contact your doctor if you have missed one or more doses.

Do not take a double dose to make up for a forgotten dose.

If you stop taking Levetiracetam:

If you have any further questions on the use of this product, ask your doctor or pharmacist.

| 4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Tell your doctor immediately, or go to your nearest emergency department, if you experience:

weakness, feel light-headed or dizzy or have difficulty breathing, as these may be signs of a serious allergic (anaphylactic) reaction
swelling of the face, lips, tongue and throat (Quincke's oedema)
flu-like symptoms and a rash on the face followed by an extended rash with a high temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes (Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS])
symptoms such as low urine volume, tiredness, nausea, vomiting, confusion and swelling in the legs, ankles or feet, as this may be a sign of sudden decrease of kidney function
a skin rash which may form blisters and look like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) (erythema multiforme)
a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome)
a more severe form of rash causing skin peeling in more than 30% of the body surface (toxic epidermal necrolysis)
signs of serious mental changes or if someone around you notices signs of confusion, somnolence (sleepiness), amnesia (loss of memory), memory impairment (forgetfulness), abnormal behaviour or other neurological signs including involuntary or uncontrolled movements. These could be symptoms of an encephalopathy.

Very common: may affect more than 1 in 10 people

nasopharyngitis
somnolence (sleepiness); headache

Common: may affect up to 1 in 10 people

anorexia (loss of appetite)
depression, hostility or aggression, anxiety, insomnia, nervousness or irritability
convulsion, balance disorder (equilibrium disorder), dizziness (sensation of unsteadiness), lethargy (lack of energy and enthusiasm), tremor (involuntary trembling)
vertigo (sensation of rotation)
cough
abdominal pain, diarrhoea, dyspepsia (indigestion), vomiting, nausea
rash
asthenia/fatigue (tiredness).

Uncommon: may affect up to 1 in 100 people

decreased number of blood platelets, decreased number of white blood cells
weight decrease, weight increase
suicide attempt and suicidal ideation, mental disorder, abnormal behaviour, hallucination, anger, confusion, panic attack, emotional instability/mood swings, agitation
amnesia (loss of memory), memory impairment (forgetfulness), abnormal coordination/ataxia (impaired coordinated movements), paraesthesia (tingling), disturbance in attention (loss of concentration)
diplopia (double vision), vision blurred;
elevated/abnormal values in a liver function test
hair loss, eczema, pruritus
muscle weakness, myalgia (muscle pain)
injury.

Rare: may affect up to 1 in 1,000 people

infection
decreased number of all blood cell types
severe allergic reactions (DRESS, anaphylactic reaction [severe and important allergic reaction], Quincke's oedema [swelling of the face, lips, tongue and throat])
decreased blood sodium concentration
suicide, personality disorders (behavioural problems), thinking abnormal (slow thinking, unable to concentrate)
delirium;
encephalopathy (see sub-section „Tell your doctor immediately“ for a detailed description of symptoms);
uncontrollable muscle spasms affecting the head, torso and limbs, difficulty in controlling movements, hyperkinesia (hyperactivity)
pancreatitis
liver failure, hepatitis
sudden decrease in kidney function
skin rash, which may form blisters and looks like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge) (erythema multiforme), a widespread rash with blisters and peeling skin, particularly around the mouth, nose, eyes and genitals (Stevens Johnson syndrome), and a more severe form causing skin peeling in more than 30% of the body surface (toxic epidermal necrolysis).
rhabdomyolysis (breakdown of muscle tissue) and associated blood creatine phosphokinase increase. Prevalence is significantly higher in Japanese patients when compared to non-Japanese patients.
seizures may become worse or happen more often;
change of the heart rhythm (Electrocardiogram);
limp or difficulty walking.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme website or search for MHRA Yellow Card in the Google Play or Apple App Store.' By reporting side effects you can help provide more information on the safety of this medicine.

| 5. How to store Levetiracetam |

Keep this medicine out of the sight and reach of children.
This medicinal product does not require any special storage conditions.
Do not use this medicine after the expiry date stated on the carton box and blister after “EXP.” The expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment

| 6. Contents of the pack and other information |

What Levetiracetam contains

The active substance is Levetiracetam.

Each 250 mg tablet contains 250 mg Levetiracetam.

Each 500 mg tablet contains 500 mg Levetiracetam.

Each 750 mg tablet contains 750 mg Levetiracetam.

Each 1000 mg tablet contains 1000 mg Levetiracetam.