Patient leaflet - IMIGRAN 100 MG TABLETS, SUMATRIPTAN 100 MG TABLETS
IMIGRAN100 mg tablets
(sumatriptan succinate)
Your medicine is known by the above names, but will be referred to as Imigran® throughout this leaflet
This medicine is also available in another strength.
Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
- Keep this leaflet. You may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it on to others – it may harm them, even if their signs of illness are the same as yours.
- If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
What is in this leaflet
1 What Imigran® is and what it is used for
2 What you need to know before you use Imigran®
3 How to use Imigran®
4 Possible side effects
5 How to store Imigran®
6 Contents of the pack and other information
1 what imigran® is and what it is used for
Each Imigran® capsule-shaped tablet contains a single dose of sumatriptan, which belongs to a group of medicines called triptans (also known as 5-HTi receptor agonists).
Imigran® is used to treat migraine headache.
Migraine symptoms may be caused by the temporary widening of blood vessels in the head. Imigran® is believed to reduce the widening of these blood vessels. This in turn helps to take away the headache and relieve other symptoms of a migraine attack, such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound.
2 what you need to know before you use imigran®
Don’t use Imigran®:
- If you’re allergic to sumatriptan, or any of the other ingredients of this medicine (listed in section 6)
- If you have a heart problem such as narrowing of the arteries (Ischaemic heart disease) or chest pains (angina), or have already had a heart attack
- If you have circulation problems in your legs that cause cramp-like pains when you walk (peripheral vascular disease)
- If you have had a stroke or a mini-stroke (also called a transient ischaemic attack or TIA)
- If you have high blood pressure. You may be able to use Imigran® if your high blood pressure is mild and is being treated
- If you have serious liver disease
- With other migraine medicines, including those which contain ergotamine, or similar medicines such as methysergide maleate; or any triptan or 5HTi agonist (such as naratriptan orzolmitriptan)
- With any of the following anti-depressants:
- MAOIs (monoamine oxidase inhibitors) or if you have taken an MAOI in the last 2 weeks
- For children under 18 years of age.
If any of these apply to you:
- Tell your doctor, and don’t use Imigran® tablets.
Take special care with Imigran®
Talk to your doctor or pharmacist before using Imigran®.
If you have any extra risk factors
- If you are a heavy smoker, or using nicotine replacement therapy, and especially
- If you are a man aged over 40, or
- If you are a woman who has been through the menopause.
In very rare cases, people have developed serious heart conditions after using Imigran®, even though they had no signs of heart disease before.
If any of the points above applies to you it could mean you have a greater risk of developing heart disease – so:
-
- Tell your doctor so that your heart function can be checked before Imigran® is prescribed for you.
If you have a history of fits (seizures)
Or if you have other conditions which might make it more likely that you’ll have a fit – for example, a head injury or alcoholism:
-
- Tell your doctor so that you can be supervised more closely.
If you have had high blood pressure Imigran® may not be suitable for you
-
- Tell your doctor or pharmacist before using Imigran®.
If you have liver or kidney disease
If either of these apply to you:
-
- Tell your doctor or pharmacist before using Imigran®.
If you have an intolerance to some sugars
-
- Tell your doctor so that you can be supervised more closely.
If you are allergic to antibiotics called sulphonamides
If so, you may also be allergic to Imigran®. If you know you are allergic to an antibiotic but you are not sure whether it is a sulphonamide:
-
- Tell your doctor or pharmacist before using Imigran®.
If you are taking anti-depressants called SSRIs
(Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors)
-
- Tell your doctor or pharmacist before using
Imigran®. Also see Other medicines and Imigran®, below.
If you use Imigran® frequently.
Using Imigran® too often may make your headaches worse.
-
- Tell your doctor if this applies to you. He or she may recommend you stop using Imigran®.
If you feel pain or tightness in your chest after you use Imigran®
These effects may be intense but they usually pass quickly. If they don’t pass quickly, or they become severe:
- get medical help immediately. section 4 (overleaf) has more information about these possible side effects.
Other medicines and Imigran®
Tell your doctor or pharmacist if you’re taking, have recently taken or might take any other medicines. This includes any herbal products or medicines you’ve bought without a prescription.
Some medicines must not be taken with Imigran® and others may cause adverse effects if they’re taken with Imigran®. You must tell your doctor if you are taking:
- ergotamine also used to treat migraine, or similar medicines such as methysergide (see section 2 Don’t use Imigran®). Don’t use Imigran® at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigran®. Don’t take any medicines which contain ergotamine or compounds similar to ergotamine again for at least 6 hours after using Imigran®.
- other triptans/5-HTi receptor agonists (such as naratriptan, rizatriptan, zolmitriptan), also used to treat migraine, (see section 2 Don’t use Imigran®). Don’t use Imigran® at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigran®. Don’t take another triptan/5-HT! receptor agonist again for at least 24 hours after using Imigran®.
- MAOIs used to treat depression. Don’t use Imigran® if you have taken these in the last 2 weeks.
- SSRIs and SNRIs used to treat depression. Using Imigran® with these medicines can cause serotonin syndrome (a collection of symptoms which can include restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms, shivering, increased heartbeat and shaking). Tell your doctor immediately if you are affected in this way.
- St John’s Wort (Hypericum perforatum). Taking herbal remedies that contain St John’s Wort together with Imigran® may make side effects more likely.
- If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. There is only limited information about the safety of Imigran® for pregnant women, though up till now there is no evidence of any increased risk of birth defects. Your doctor will discuss with you whether or not you should use Imigran® while you are pregnant
- Don’t breast-feed your baby for 12 hours after using Imigran®. If you express any breast milk during this time, discard the milk and don’t give it to your baby.
Driving and using machines
Either the symptoms of migraine or your medicine may make you drowsy. If you are affected, don’t drive or operate machinery.
Imigran® contains
-
- Lactose: If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product,
-
- Sodium: This medicine contains less than 1 mmol sodium (23mg) per tablet, that is to say essentially ‚sodium free‘
3 how to use imigran®
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
When to take Imigran®
- It’s best to take Imigran® as soon as you feel a migraine coming on, although – you can take it at any time during an attack
- Don’t use Imigran® to try to prevent an attack – only use it after your migraine symptoms start.
- The usual dose for adults aged 18 to 65 is one Imigran® 50 mg tablet, swallowed whole with water. Some patients may need a 100 mg dose – you should follow your doctor’s advice.
- Imigran® is not recommended for children under 18 years old.
- Imigran® is not recommended for people aged over 65.
- You can take a second Imigran® tablet if at least 2 hours have passed since the first tablet. Don’t take more than 300 mg in total in 24 hours.
- Don’t take a second tablet or any other Imigran® preparation for the same attack. Imigran® can still be used for your next attack.
If Imigran® doesn’t give you any relief:
- Ask your doctor or pharmacist for advice.
If you take more Imigran® than you should
- Don’t take more than six 50 mg tablets or three 100 mg tablets (300 mg in total) in any 24 hours.
Taking too much Imigran® could make you ill. If you have taken more than 300 mg in 24 hours:
- Contact your doctor for advice.
If you have any further questions about the use of this medicine, ask your doctor or pharmacist.
4 POSSIBLE SIDE EFFECTS
Like all medicines, this medicine can cause side effects, but not everybody gets them. Some symptoms may be caused by the migraine itself.
Allergic reaction: get doctor’s help straight away
The following side effects have occurred but their exact frequency is not known.
- The signs of allergy include rash, hives (itchy rash); wheezing; swollen eyelids, face or lips; complete collapse.
If you get any of these symptoms soon after using Imigran®:
- Don’t use any more. Contact a doctor straight away.
Common side effects
(affect up to 1 in 10 people)
- Pain, heaviness, pressure or tightness in the chest, throat or other parts of the body, or unusual sensations, including numbness, tingling and warmth or cold. These effects may be intense but generally pass quickly.
If these effects continue or become severe (especially the chest pain):
- Get medical help urgently. In a very small number of people these symptoms can be caused by a heart attack.
Other common side effects include:
- Feeling sick (nausea) or being sick (vomiting), although this may be due to the migraine itself
- Tiredness or drowsiness
- Dizziness, feeling weak, or getting hot flushes
- Temporary increase in blood pressure
- Shortness of breath
- Aching muscles.
Very rare side effects
(affect up to 1 in 10,000 people)
- Liver function changes. If you have a blood test to check your liver function, tell your doctor or nurse that you are taking Imigran®.
- Seizures/fits, tremors, muscle spasm, neck stiffness
- Visual disturbances such as flickering, reduced vision, double vision, loss of vision, and in some cases even permanent defects (although these may be due to the migraine attack itself)
- Heart problems, where your heartbeat may go faster, slower or change rhythm, chest pains (angina) or heart attack
- Pale, blue-tinged skin and/or pain in your fingers, toes, ears, nose or jaw in response to cold or stress (Raynaud’s phenomenon)
- Feeling faint (blood pressure may go down)
- Pain in the lower left side of the stomach and bloody diarrhoea (ischaemic colitis)
- Diarrhoea
- If you had a recent injury or if you have inflammation (like rheumatism or inflammation of the colon) you may experience pain or pain worsening at the site of injury or inflammation.
- Pain in the joints
- Feeling anxious
- Difficulty swallowing
- Excessive sweating
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects, you can help provide more information on the safety of this medicine.
5 HOW TO STORE IMIGRAN®
- Keep out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the label after EXP. The expiry date refers to the last day of that month.
- Do not store above 25°C.
- If the tablets become discoloured or show any other signs of deterioration, you should seek the advice of your pharmacist who will tell you what to do.
- Medicines should not be disposed of via wastewater or household waste. These measures will help protect the environment.
6 CONTENTS OF THE PACK AND OTHER INFORMATION
What Imigran® contains
- Each tablet contains 10Omg sumatriptan (as the succinate)
- The other ingredients are lactose monohydrate, microcrystalline cellulose, croscarmellose sodium type A, magnesium stearate, methylhydroxypropylcellulose (hypromellose) and titanium dioxide (E171) Cl 77891.
What Imigran® looks like and contents of the pack
Imigran® tablets are white or off-white, capsule-shaped, biconvex tablet engraved 100 on one face and plain on the other face.
They are available in a pack size 2 and 6 tablets.
Manufactured by GlaxoSmithKline Pharmaceuticals SA, Poznan, Poland.
Procured from within the EU and repackaged by the Product Licence Holder Beachcourse Ltd., 20 Alliance Court, Alliance Road, London W3 ORB, UK.
Revision date: 24.03.2021
PL 16378/0692 |POM|
Imigran® is a registered trademark of GlaxoSmithKline Group of companies.
Blind or partially sighted?
Is this leaflet hard to see or read?
Phone Beachcourse,
Tel: 020 8896 9054 for help.
3