Patient leaflet - Clonidine Hydrochloride 25 micrograms tablets
1. WHAT CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS ARE AND WHAT THEY ARE USED FOR
Clonidine Hydrochloride 25 Microgram Tablets contain a medicine called “clonidine hydrochloride”. This belongs to a group of medicines called 'vasodilators', which cause widening of the blood vessels and therefore an increase in blood flow.
Your doctor has prescribed Clonidine Hydrochloride 25 Microgram Tablets for you to prevent attacks of migraine and similar types of headache. The tablets are also used to prevent hot fushes that may occur in women during the menopause ('change of life').
2. BEFORE YOU TAKE CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS
Do not take CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS if:
You are allergic to clonidine hydrochloride or any of the other ingredients of
this medicine (listed in section 6).
You have a slow heart rate resulting from a disease of the heart called
'sick-sinus syndrome' or severe heart problems.
Do not take Clonidine Hydrochloride 25 microgram Tablets if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking this medicine.
Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking Clonidine Hydrochloride 25 Microgram Tablets if you have
Raynaud's disease (a problem with circulation to the fingers and toes) or
other blood circulation
- problems, including circulation to the brain heart or kidney problems
- or have ever had depression
- constipation
a nerve disorder that causes your hands and feet to feel different ('altered
sensation').
If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Clonidine Hydrochloride 25 Microgram Tablets. As you may get dry eyes whilst taking this medicine, this may be a problem if you wear contact lenses.
Children and adolescents
Clonidine Hydrochloride 25 Microgram Tablets are not recommended in children and adolescents under 18 years.
Other medicines and Clonidine Hydrochloride 25 Microgram Tablets
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription and herbal medicines. This is because Clonidine Hydrochloride 25 Microgram Tablets can affect the way some other medicines work, and some other medicines can affect the way Clonidine Hydrochloride 25 Microgram Tablets work. In particular, tell your doctor or pharmacist if you are taking any of the following medicines:
certain medicines used to lower blood pressure (antihypertensives and alpha
blockers); alpha-blockers are medicines also used to treat swelling of the prostate gland
- certain medicines that relax blood vessels (vasodilators)
- water tablets (diuretics)
medicines which are often used to slow the heart rate or lower the blood
pressure (beta blockers)
- medicines used to treat heart failure (cardiac glycosides)
- certain medicines used to treat depression (tricyclic antidepressants)
- other antidepressants, e.g. mirtazapine
certain medicines used to relieve anxiety such as tranquillisers, hypnotics
(and also alcohol) (neuroleptics).
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Clonidine Hydrochloride 25 Microgram Tablets.
Clonidine Hydrochloride 25 Microgram Tablets and alcohol
You may feel drowsy while taking Clonidine Hydrochloride 25 Microgram Tablets. Drinking alcohol while taking Clonidine Hydrochloride 25 Microgram Tablets can make this worse.
Pregnancy, breast-feeding and fertility
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Clonidine Hydrochloride 25 Microgram Tablets can reach your baby and may lower your baby's heart rate.
Clonidine Hydrochloride 25 Microgram Tablets are not recommended for use while breast-feeding. If you want to breast feed, please consult your doctor first.
Driving and using machines
You may feel drowsy, dizzy or could have some disturbances of vision. If affected, you should not drive, operate machinery or take part in any activities where these may put you or others at risk.
Clonidine Hydrochloride 25 Microgram Tablets contains lactose
This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
3. HOW TO TAKE CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS
Always take your medicine exactly as your doctor or pharmacist has told you. You should check with your doctor or pharmacist if you are not sure. Clonidine Hydrochloride 25 Microgram Tablets should not be taken continuously for long periods of time.
Taking this medicine
The tablets should be swallowed whole with water, with or without food. It may take 2 to 4 weeks for the medicine to work properly.
How much to take
Adults 18 years and over
The recommended dose is two to three tablets twice a day
PRODUCT NAME
PRODUCT LICENCE NO.
STRENGTH
PACK SIZE
FONT & SIZE
REMARKS
REASON FOR CHANGE
COUNTRY
MANUFACTURER
SOFTWARE
ARTIST
Clonidine Hydrochloride 25 microgram Tablets
20395-0386
Pil
210 x 297 mm
25 mcg
112s
Arial Narrow (15 pt, 9 pt)
-
Comments received from Steph on 22.08.2025.
UK (English)
Gpax Pharma
Adobe illustrator CC
Gurukiran
NO. OF COLORS 01
██ Black
██ Dieline
0.5
VERSION XXXXX DATE 22.08.2025
If you take more Clonidine Hydrochloride Tablets than you should:
If you take more tablets than you should or if a child accidentally swallows any, go to your doctor or nearest emergency department immediately and take your medicine pack with you. Symptoms of overdose include sleepiness (including coma), breathing difficulties, being sick, low blood pressure and dry mouth.
If you forget to take Clonidine Hydrochloride:
If you forget to take a dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose. Do not take a double dose to make up for a forgotten dose.
If you stop taking Clonidine Hydrochloride:
Do not stop taking Clonidine Hydrochloride Tablets without talking to your doctor first.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
4. POSSIBLE SIDE EFFECTS
Like all medicines, this medicine can cause side effects, although not everybody gets them. Tell your doctor or pharmacist immediately if you experience any of the following:
Very common (affects more than 1 in 10 people):
- Dizziness, feeling tired and more relaxed than usual (sedation)
Feeling dizzy when you stand up (because your blood pressure has fallen
sharply)
- Dry mouth.
Common (affects less than in 1 in 10 people, more than 1 in 25 people)
- Depression, sleeping problems
- Headache
Constipation, feeling sick (nausea), pain below the ear (from the salivary
gland), being sick (vomiting)
- Erectile dysfunction
- Fatigue.
Uncommon (affects less than 1 in 25 people, more than 1 in 1,000 people)
Problems with understanding what is happening around you, hallucinations,
nightmares
- Your hands and feet feeling different (‘altered sensation’)
- Regular unusually slow heartbeat
- Raynaud’s phenomenon (a problem with circulation to the fingers and toes)
- Itching, rash, urticaria (nettle rash)
- A feeling of discomfort and fatigue (‘malaise’).
Rare (affects less than 1 in 1,000 people):
- Breast growth (‘gynaecomastia’) in men
- Dry eyes
- Irregular heartbeat
- Drying out of the lining of the nose
Pseudo-obstruction of the large bowel, which causes colicky pain, vomiting
and constipation.Contact your doctor straight away if you have all these side effects.
- Hair loss
- Increase in your blood sugar.
Not known (frequency cannot be estimated from the available data)
- Confusion, loss of libido
- Blurred vision
- Abnormally slow heartbeat.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for 'MHRA Yellow Card' in the Google play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
5. HOW TO STORE CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS
Keep out of sight and reach of children.
The tablets should not be stored above 25°C and the blister strips should be kept in the outer carton.
Do not use Clonidine Hydrochloride 25 microgram Tablets after the expiry date which is stated on the packaging. The expiry date refers to the last day of that month.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.
6. FURTHER INFORMATION
What CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS contains
- The active substance is clonidine hydrochloride. Each tablet contains 25 micrograms.
- The other ingredients are: Pregelatinised maize starch, Lactose monohydrate, Isopropyl alcohol, Calcium hydrogen phosphate dihydrate (E341), Colloidal anhydrous silica, Magnesium Stearate, Purified water, Opadry II Blue (which contains Polyvinyl alcohol (E1203), Talc (E5536), Titanium dioxide (E171), HPMC (E464), Polyethylene glycol (E1521) and FD+C Blue (E133).
What CLONIDINE HYDROCHLORIDE 25 MICROGRAM TABLETS looks like and contents of the pack
- Clonidine Hydrochloride 25 microgram Tablets are blue coloured round biconvex approx. 6 mm film coated tablets embossed with “0.025” on one side & plain on other side.
Clonidine Hydrochloride 25 microgram Tablets are available in blister packs of 112 tablets.
Marketing Authorisation Holder and Manufacturer
Relonchem Ltd.,
Cheshire House,
Gorsey Lane, Widnes, Cheshire,
WA8 0RP, UK.
PL 20395/0386
This leaflet was last revised in August 2025.