1) what neomercazole is and what it is used for

NeoMercazole contains the active substance carbimazole. NeoMercazole belongs to a group of medicines called anti-thyroid agents. NeoMercazole is used to reduce the formation of thyroid hormones in adults and children with overactive thyroid gland. The condition is called hyperthyroidism. NeoMercazole is also used in more serious cases, for example, to restore the normal function of the thyroid before its partial removal by surgery. It may also be used together with other treatments for hyperthyroidism,

2) what you need to know before you take neomercazole

Do not take NeoMercazole

• If you are allergic to carbimazole or any of the ingredients of NeoMercazole.
• If you are allergic to other anti-thyroid medications such as thiamazole, methimazole or propylthiouracil.
• If you are breast-feeding.
• If you have a serious blood disorder.
• If you have a severe liver disorder.
• If you had inflammation of the pancreas (acute pancreatitis) after administration of carbimazole or thiamazole in the past.
• If you have a swelling in your neck called an ‚intrathoracic goitre‘.
• If you have bone marrow depression.
• If you are receiving radio-iodine (for thyroid problems).
• If you are of child-bearing potential.
• If you are allergic to thiamazole, methimazole or propylthiouracil (other thyroid medications).
• If you are lactose intolerant or have any other lactose deficiency.
• If you are sucrose intolerant or have any other sucrose deficiency.
• If you are unable to comply with the instructions for use or cannot be monitored regularly.
• If you are pregnant, think you may be pregnant or are trying to become pregnant.
• If you have mild or moderate liver problems.
• Tell your doctor straight away if you develop fever or abdominal pain, which may be signs of inflammation of the pancreas (acute pancreatitis). NeoMercazole may need to be discontinued.
• NeoMercazole can cause harm to an unborn baby. If you could get pregnant, use reliable contraception from the time you start treatment and during treatment.

If you are not sure if the above applies to you, talk to your doctor or pharmacist before taking NeoMercazole.

Children

Do not give this medicine to children under the age of two years because it may not be safe or effective.

Other medicines and NeoMercazole

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines obtained without a prescription, including herbal medicines. This is because NeoMercazole can affect the way some medicines work. Also, some medicines can affect the way NeoMercazole works.

In particular tell your doctor or pharmacist if you are taking any of the following:

• Theophylline used to treat asthma or breathing problems
• Medicines called anticoagulants, which are used to thin the blood e.g. warfarin
• Steroids such as prednisolone
• An antibiotic called erythromycin
• A medicine for heart failure called digitalis
• Medicines for high blood pressure called beta-blockers

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice straight away before taking this medicine.

Pregnancy

NeoMercazole can cause harm to an unborn baby. If you could get pregnant, use reliable contraception from the time you start treatment and during treatment. However, to reduce the possibility of any effects on your baby:

• Your doctor should prescribe the lowest dose possible.
• Your treatment may be discontinued three to four weeks before you are due to give birth.

Your treatment with NeoMercazole may need to be continued during pregnancy if the potential benefit outweighs the potential risk to you and your unborn baby.

Breast-feeding

You should not breast-feed if you are using NeoMercazole. This is because small amounts may pass into the mother's milk. Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

You can drive when taking NeoMercazole, but do not drive until you know how it affects you.

NeoMercozole contains lactose and sucrose

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3) how to take neomercazole

Always take NeoMercazole exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

• The tablets should be taken by mouth.
• You can take the tablets before, after or during meals.
• Each day’s tablets may be divided into two (morning and evening) or three daily doses (morning, noon and night).

Adults and the elderly: The recommended starting dose is one to three 20 mg tablets, or four to twelve 5 mg tablets daily. Once control is achieved your doctor will gradually reduce your dose to one to three 5 mg tablets each day.

Use in children: The recommended starting dose is three 5 mg tablets daily.

The dosage will be decided by your doctor according to your individual needs, and may be changed at intervals during treatment.

Do not change the dosage without consulting your doctor first.

Your doctor may decide to add an additional tablet (I-thyroxine), to help control your condition.

Some improvement is usually felt within one to three weeks. However, full beneficial effects usually take four to eight weeks.

In order to maintain control of the thyroid gland, you may need to continue to take NeoMercazole tablets for several months. Your doctor will decide when treatment can be stopped. They may ask you to have occasional blood tests to help them to determine how you are responding to treatment.

Radio-iodine is another treatment for hyperthyroidism. If you need radioiodine treatment, your doctor will tell you to stop taking NeoMercazole temporarily.

If you take more NeoMercazole than you should

If you take more NeoMercazole than you should, contact your doctor or nearest hospital emergency department immediately. Take the container and any remaining tablets with you.

If you forget to take NeoMercazole

If you forget to take NeoMercazole take the next dose as soon as you remember. If your next dose is due, take both doses together.

If you have any further questions of the use of this medicine ask your doctor or pharmacist.

4) possible side effects

Like all medicines, NeoMercazole can cause side effects, although not everybody gets them.

Allergic reactions

If you have an allergic reaction, stop taking NeoMercazole and see a doctor straight away. The signs may include: sudden rash, swelling or difficulty breathing.

Stop taking NeoMercazole and see a doctor straight away if you notice any of the following side effects:

• sore throat
• mouth ulcers
• high temperature or fever
• significant tiredness
• increased bruising or bleeding tendency
• you are feeling generally unwell or think that you may have on infection
• stevens-Johnson syndrome, a serious illness with blistering of the skin, mouth, eyes and genitals
• angioedema, a serious allergic reaction with symptoms that may include swollen tongue, lips, face or throat

In addition, if you experience any of these symptoms while taking NeoMercazole you should also contact your doctor immediately:

• Muscle pain or weakness
• Nerve pain
• Swelling of lymph nodes
• Swelling of glands in your mouth
• Feeling faint (low blood sugar)
• yellowing of your skin or whites of your eyes.

These could be signs of muscle problems, jaundice or inflammation of the liver and under medical supervision your doctor may want you to stop taking the medicine and carry out some blood tests on you.

Do not stop taking NeoMercazole until you have consulted your doctor. NeoMercazole can sometimes cause bone marrow depression which causes a reduction in the number of blood cells and reduces the ability to fight infection. If it is not treated as soon as it is detected the condition can become life-threatening. Your doctor should carry out tests to check for bone marrow depression before restarting your treatment.

The following side effects are reported with a not known frequency (frequency cannot be estimated from the available data):

Other side effects include:

• feeling sick
• headache
• skin rashes, including urticaria (nettle rash)
• itching
• stomach upset
• painful joints.
• hair loss
• loss of taste
• inflammation of the pancreas (acute pancreatitis)
• lung problems, with symptoms that include shortness of breath or a cough
• Kidney problems, with symptoms that include a reduction in the amount of urine passed, fluid retention and blood in the urine.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:

or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

5) how to store neomercazole

• Keep this medicine out of the sight and reach of children.

• Do not use after the expiry date printed on the carton, and bottle label after EXP. The expiry date refers to the last day of that month.
• Do not store above 25°C. Store in the original container.
• If the tablets become discoloured or show any other signs of deterioration, you should seek the advice of your pharmacist who will tell you what to do.
• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6) contents of the pack and other information

What NeoMercazole contains:

The active substance is carbimazole. Each tablet contains 5mg carbimazole.

The other ingredients are lactose monohydrate, maize starch, gelatin, magnesium stearate, sucrose, acacia, talc and red iron oxide (E172).

What NeoMercazole looks like and content of the pack

NeoMercazole 5mg tablets are pink, round, biconvex, uncoated tablets with Neo 5 stamped on one side and plain on the other.

NeoMercazole 5mg is available in plastic bottles of 100 tablets.

PL 46420/0369 NeoMercazole 5mg Tablets |POM|

Who makes and repackages your medicine

Your medicine is manufactured by Cenexi SAS, 52 rue Marcel et Jacques Gaucher, 94120 Fontenay-sous-Bois, France. Procured from within the EU and repackaged by the Product Licence holder: Suerte Pharma Ltd, 4/5 Northolt Trading Estate, Belvue Road, Northolt, Middlesex, UB5 5QS.

Leaflet date: 09.03.2020

NeoMercazole® is a registered trademark of Amdipharm AG, Basle, Switzerland.

Blind or partially sighted?

Is this leaflet hard to see or read?

Call 020 8839 3000 to obtain the leaflet in a format suitable for you.

Your medicine is known by the above name, but will be referred to as Carbimazole throughout this leaflet. Carbimazole is also available as the 20mg strength.

Patient Information Leaflet

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

• – Keep this leaflet. You may need to read it again.

• – If you have any further questions, ask your doctor or pharmacist.

• – This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

• – If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet:

• 1) What Carbimazole is and what it is used for

• 2) What you need to know before you take Carbimazole

• 3) How to take Carbimazole

• 4) Possible side effects

• 5) How to store Carbimazole

• 6) Contents of the pack and other information

1) what carbimazole is and what it is used for

Carbimazole contains the active substance carbimazole. Carbimazole belongs to a group of medicines called anti-thyroid agents. Carbimazole is used to reduce the formation of thyroid hormones in adults and children with overactive thyroid gland. The condition is called hyperthyroidism. Carbimazole is also used in more serious cases, for example, to restore the normal function of the thyroid before its partial removal by surgery. It may also be used together with other treatments for hyperthyroidism,

2) what you need to know before you take carbimazole

Do not take Carbimazole

• If you are allergic to carbimazole or any of the ingredients of Carbimazole.
• If you are allergic to other anti-thyroid medications such as thiamazole, methimazole or propylthiouracil.
• If you are breast-feeding.
• If you have a serious blood disorder.
• If you have a severe liver disorder.
• If you had inflammation of the pancreas (acute pancreatitis) after administration of carbimazole or thiamazole in the past.
• If you have a swelling in your neck called an ‚intrathoracic goitre‘.
• If you have bone marrow depression.
• If you are receiving radio-iodine (for thyroid problems).
• If you are of child-bearing potential.
• If you are allergic to thiamazole, methimazole or propylthiouracil (other thyroid medications).
• If you are lactose intolerant or have any other lactose deficiency.
• If you are sucrose intolerant or have any other sucrose deficiency.
• If you are unable to comply with the instructions for use or cannot be monitored regularly.
• If you are pregnant, think you may be pregnant or are trying to become pregnant.
• If you have mild or moderate liver problems.
• Tell your doctor straight away if you develop fever or abdominal pain, which may be signs of inflammation of the pancreas (acute pancreatitis). Carbimazole may need to be discontinued.
• Carbimazole can cause harm to an unborn baby. If you could get pregnant, use reliable contraception from the time you start treatment and during treatment.

If you are not sure if the above applies to you, talk to your doctor or pharmacist before taking Carbimazole.

Children

Do not give this medicine to children under the age of two years because it may not be safe or effective.

Other medicines and Carbimazole

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines obtained without a prescription, including herbal medicines. This is because Carbimazole can affect the way some medicines work. Also, some medicines can affect the way Carbimazole works.

In particular tell your doctor or pharmacist if you are taking any of the following:

• Theophylline used to treat asthma or breathing problems
• Medicines called anticoagulants, which are used to thin the blood e.g. warfarin
• Steroids such as prednisolone
• An antibiotic called erythromycin
• A medicine for heart failure called digitalis
• Medicines for high blood pressure called beta-blockers

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice straight away before taking this medicine.

Pregnancy

Carbimazole can cause harm to an unborn baby. If you could get pregnant, use reliable contraception from the time you start treatment and during treatment. However, to reduce the possibility of any effects on your baby:

• Your doctor should prescribe the lowest dose possible.
• Your treatment may be discontinued three to four weeks before you are due to give birth.

Your treatment with Carbimazole may need to be continued during pregnancy if the potential benefit outweighs the potential risk to you and your unborn baby.

Breast-feeding

You should not breast-feed if you are using Carbimazole. This is because small amounts may pass into the mother's milk. Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

You can drive when taking Carbimazole, but do not drive until you know how it affects you.

NeoMercozole contains lactose and sucrose

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3) how to take carbimazole

Always take Carbimazole exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

• The tablets should be taken by mouth.
• You can take the tablets before, after or during meals.
• Each day’s tablets may be divided into two (morning and evening) or three daily doses (morning, noon and night).

Adults and the elderly: The recommended starting dose is one to three 20 mg tablets, or four to twelve 5 mg tablets daily. Once control is achieved your doctor will gradually reduce your dose to one to three 5 mg tablets each day.

Use in children: The recommended starting dose is three 5 mg tablets daily.

The dosage will be decided by your doctor according to your individual needs, and may be changed at intervals during treatment.

Do not change the dosage without consulting your doctor first.

Your doctor may decide to add an additional tablet (I-thyroxine), to help control your condition.

Some improvement is usually felt within one to three weeks. However, full beneficial effects usually take four to eight weeks.

In order to maintain control of the thyroid gland, you may need to continue to take Carbimazole tablets for several months. Your doctor will decide when treatment can be stopped. They may ask you to have occasional blood tests to help them to determine how you are responding to treatment.

Radio-iodine is another treatment for hyperthyroidism. If you need radioiodine treatment, your doctor will tell you to stop taking Carbimazole temporarily.

If you take more Carbimazole than you should

If you take more Carbimazole than you should, contact your doctor or nearest hospital emergency department immediately. Take the container and any remaining tablets with you.

If you forget to take Carbimazole

If you forget to take Carbimazole take the next dose as soon as you remember. If your next dose is due, take both doses together.

If you have any further questions of the use of this medicine ask your doctor or pharmacist.

4) possible side effects

Like all medicines, Carbimazole can cause side effects, although not everybody gets them.

Allergic reactions

If you have an allergic reaction, stop taking Carbimazole and see a doctor straight away. The signs may include: sudden rash, swelling or difficulty breathing.

Stop taking Carbimazole and see a doctor straight away if you notice any of the following side effects:

• sore throat
• mouth ulcers
• high temperature or fever
• significant tiredness
• increased bruising or bleeding tendency
• you are feeling generally unwell or think that you may have on infection
• stevens-Johnson syndrome, a serious illness with blistering of the skin, mouth, eyes and genitals
• angioedema, a serious allergic reaction with symptoms that may include swollen tongue, lips, face or throat

In addition, if you experience any of these symptoms while taking Carbimazole you should also contact your doctor immediately:

• Muscle pain or weakness
• Nerve pain
• Swelling of lymph nodes
• Swelling of glands in your mouth
• Feeling faint (low blood sugar)
• yellowing of your skin or whites of your eyes.

These could be signs of muscle problems, jaundice or inflammation of the liver and under medical supervision your doctor may want you to stop taking the medicine and carry out some blood tests on you.

Do not stop taking Carbimazole until you have consulted your doctor. Carbimazole can sometimes cause bone marrow depression which causes a reduction in the number of blood cells and reduces the ability to fight infection. If it is not treated as soon as it is detected the condition can become life-threatening. Your doctor should carry out tests to check for bone marrow depression before restarting your treatment.

The following side effects are reported with a not known frequency (frequency cannot be estimated from the available data):

Other side effects include:

• feeling sick
• headache
• skin rashes, including urticaria (nettle rash)
• itching
• stomach upset
• painful joints.
• hair loss
• loss of taste
• inflammation of the pancreas (acute pancreatitis)
• lung problems, with symptoms that include shortness of breath or a cough
• Kidney problems, with symptoms that include a reduction in the amount of urine passed, fluid retention and blood in the urine.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:

or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

5) how to store carbimazole

• Keep this medicine out of the sight and reach of children.

• Do not use after the expiry date printed on the carton, and bottle label after EXP. The expiry date refers to the last day of that month.
• Do not store above 25°C. Store in the original container.
• If the tablets become discoloured or show any other signs of deterioration, you should seek the advice of your pharmacist who will tell you what to do.
• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6) contents of the pack and other information

What NeoMercazole contains:

The active substance is carbimazole. Each tablet contains 5mg carbimazole.

The other ingredients are lactose monohydrate, maize starch, gelatin, magnesium stearate, sucrose, acacia, talc and red iron oxide (E172).

What NeoMercazole looks like and content of the pack

NeoMercazole 5mg tablets are pink, round, biconvex, uncoated tablets with Neo 5 stamped on one side and plain on the other.

NeoMercazole 5mg is available in plastic bottles of 100 tablets.

PL 46420/0369 NeoMercazole 5mg Tablets |POM|

Who makes and repackages your medicine

Your medicine is manufactured by Cenexi SAS, 52 rue Marcel et Jacques Gaucher, 94120 Fontenay-sous-Bois, France. Procured from within the EU and repackaged by the Product Licence holder: Suerte Pharma Ltd, 4/5 Northolt Trading Estate, Belvue Road, Northolt, Middlesex, UB5 5QS.

Leaflet date: 09.03.2020

NeoMercazole® is a registered trademark of Amdipharm AG, Basle, Switzerland.

Blind or partially sighted?

Is this leaflet hard to see or read?

Call 020 8839 3000 to obtain the leaflet in a format suitable for you.

Your medicine is known by the above name, but will be referred to as Carbimazole throughout this leaflet. Carbimazole is also available as the 20mg strength.

Patient Information Leaflet

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

• – Keep this leaflet. You may need to read it again.

• – If you have any further questions, ask your doctor or pharmacist.

• – This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.

• – If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet:

• 1) What Carbimazole is and what it is used for

• 2) What you need to know before you take Carbimazole

• 3) How to take Carbimazole

• 4) Possible side effects

• 5) How to store Carbimazole

• 6) Contents of the pack and other information

1) what carbimazole is and what it is used for

Carbimazole contains the active substance carbimazole. Carbimazole belongs to a group of medicines called anti-thyroid agents. Carbimazole is used to reduce the formation of thyroid hormones in adults and children with overactive thyroid gland. The condition is called hyperthyroidism. Carbimazole is also used in more serious cases, for example, to restore the normal function of the thyroid before its partial removal by surgery. It may also be used together with other treatments for hyperthyroidism,

2) what you need to know before you take carbimazole

Do not take Carbimazole

• If you are allergic to carbimazole or any of the ingredients of Carbimazole.
• If you are allergic to other anti-thyroid medications such as thiamazole, methimazole or propylthiouracil.
• If you are breast-feeding.
• If you have a serious blood disorder.
• If you have a severe liver disorder.
• If you had inflammation of the pancreas (acute pancreatitis) after administration of carbimazole or thiamazole in the past.
• If you have a swelling in your neck called an ‚intrathoracic goitre‘.
• If you have bone marrow depression.
• If you are receiving radio-iodine (for thyroid problems).
• If you are of child-bearing potential.
• If you are allergic to thiamazole, methimazole or propylthiouracil (other thyroid medications).
• If you are lactose intolerant or have any other lactose deficiency.
• If you are sucrose intolerant or have any other sucrose deficiency.
• If you are unable to comply with the instructions for use or cannot be monitored regularly.
• If you are pregnant, think you may be pregnant or are trying to become pregnant.
• If you have mild or moderate liver problems.
• Tell your doctor straight away if you develop fever or abdominal pain, which may be signs of inflammation of the pancreas (acute pancreatitis). Carbimazole may need to be discontinued.
• Carbimazole can cause harm to an unborn baby. If you could get pregnant, use reliable contraception from the time you start treatment and during treatment.

If you are not sure if the above applies to you, talk to your doctor or pharmacist before taking Carbimazole.

Children

Do not give this medicine to children under the age of two years because it may not be safe or effective.

Other medicines and Carbimazole

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes medicines obtained without a prescription, including herbal medicines. This is because Carbimazole can affect the way some medicines work. Also, some medicines can affect the way Carbimazole works.

In particular tell your doctor or pharmacist if you are taking any of the following:

• Theophylline used to treat asthma or breathing problems
• Medicines called anticoagulants, which are used to thin the blood e.g. warfarin
• Steroids such as prednisolone
• An antibiotic called erythromycin
• A medicine for heart failure called digitalis
• Medicines for high blood pressure called beta-blockers

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice straight away before taking this medicine.

Pregnancy

Carbimazole can cause harm to an unborn baby. If you could get pregnant, use reliable contraception from the time you start treatment and during treatment. However, to reduce the possibility of any effects on your baby:

• Your doctor should prescribe the lowest dose possible.
• Your treatment may be discontinued three to four weeks before you are due to give birth.

Your treatment with Carbimazole may need to be continued during pregnancy if the potential benefit outweighs the potential risk to you and your unborn baby.

Breast-feeding

You should not breast-feed if you are using Carbimazole. This is because small amounts may pass into the mother's milk. Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

You can drive when taking Carbimazole, but do not drive until you know how it affects you.

NeoMercozole contains lactose and sucrose

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

3) how to take carbimazole

Always take Carbimazole exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

• The tablets should be taken by mouth.
• You can take the tablets before, after or during meals.
• Each day’s tablets may be divided into two (morning and evening) or three daily doses (morning, noon and night).

Adults and the elderly: The recommended starting dose is one to three 20 mg tablets, or four to twelve 5 mg tablets daily. Once control is achieved your doctor will gradually reduce your dose to one to three 5 mg tablets each day.

Use in children: The recommended starting dose is three 5 mg tablets daily.

The dosage will be decided by your doctor according to your individual needs, and may be changed at intervals during treatment.

Do not change the dosage without consulting your doctor first.

Your doctor may decide to add an additional tablet (I-thyroxine), to help control your condition.

Some improvement is usually felt within one to three weeks. However, full beneficial effects usually take four to eight weeks.

In order to maintain control of the thyroid gland, you may need to continue to take Carbimazole tablets for several months. Your doctor will decide when treatment can be stopped. They may ask you to have occasional blood tests to help them to determine how you are responding to treatment.

Radio-iodine is another treatment for hyperthyroidism. If you need radioiodine treatment, your doctor will tell you to stop taking Carbimazole temporarily.

If you take more Carbimazole than you should

If you take more Carbimazole than you should, contact your doctor or nearest hospital emergency department immediately. Take the container and any remaining tablets with you.

If you forget to take Carbimazole

If you forget to take Carbimazole take the next dose as soon as you remember. If your next dose is due, take both doses together.

If you have any further questions of the use of this medicine ask your doctor or pharmacist.

4) possible side effects

Like all medicines, Carbimazole can cause side effects, although not everybody gets them.

Allergic reactions

If you have an allergic reaction, stop taking Carbimazole and see a doctor straight away. The signs may include: sudden rash, swelling or difficulty breathing.

Stop taking Carbimazole and see a doctor straight away if you notice any of the following side effects:

• sore throat
• mouth ulcers
• high temperature or fever
• significant tiredness
• increased bruising or bleeding tendency
• you are feeling generally unwell or think that you may have on infection
• stevens-Johnson syndrome, a serious illness with blistering of the skin, mouth, eyes and genitals
• angioedema, a serious allergic reaction with symptoms that may include swollen tongue, lips, face or throat

In addition, if you experience any of these symptoms while taking Carbimazole you should also contact your doctor immediately:

• Muscle pain or weakness
• Nerve pain
• Swelling of lymph nodes
• Swelling of glands in your mouth
• Feeling faint (low blood sugar)
• yellowing of your skin or whites of your eyes.

These could be signs of muscle problems, jaundice or inflammation of the liver and under medical supervision your doctor may want you to stop taking the medicine and carry out some blood tests on you.

Do not stop taking Carbimazole until you have consulted your doctor. Carbimazole can sometimes cause bone marrow depression which causes a reduction in the number of blood cells and reduces the ability to fight infection. If it is not treated as soon as it is detected the condition can become life-threatening. Your doctor should carry out tests to check for bone marrow depression before restarting your treatment.

The following side effects are reported with a not known frequency (frequency cannot be estimated from the available data):

Other side effects include:

• feeling sick
• headache
• skin rashes, including urticaria (nettle rash)
• itching
• stomach upset
• painful joints.
• hair loss
• loss of taste
• inflammation of the pancreas (acute pancreatitis)
• lung problems, with symptoms that include shortness of breath or a cough
• Kidney problems, with symptoms that include a reduction in the amount of urine passed, fluid retention and blood in the urine.

Reporting of side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at:

or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

5) how to store carbimazole

• Keep this medicine out of the sight and reach of children.

• Do not use after the expiry date printed on the carton, and bottle label after EXP. The expiry date refers to the last day of that month.
• Do not store above 25°C. Store in the original container.
• If the tablets become discoloured or show any other signs of deterioration, you should seek the advice of your pharmacist who will tell you what to do.
• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.