Patient leaflet - Calvive 1000 effervescent tablets
1. What Calvive is and what it is used for
Calvive contains a rich source of calcium which is an essential mineral, necessary for bone formation and maintenance.
Calvive is used in the prevention and treatment of calcium deficiency, and may be used, with other medicines, to prevent and treat a condition called osteoporosis (weakening of the bones). Calvive is also used, together with vitamin D3, for the treatment of rickets (softening of growing bones in children) and osteomalacia (softening of adults bones). Calcium is absorbed from the intestine and distributed throughout the body in the blood. Calcium plays an important role in several body functions. It is essential for nerve, muscle and heart function as well as for the clotting of blood. In addition, it is necessary for many hormones to work properly in the body. To carry out these various roles, calcium must be available in the appropriate concentration.
2. What you need to know before you take Calvive
Do not take Calvive:
- If you are allergic to calcium and any of the other ingredients of Calvive (see the list of ingredients in section 6 at the end of the leaflet). • If you are suffering from raised levels of blood calcium (hypercalcaemia);
- If you are suffering from increased calcium in your urine (hypercalciuria);
If you are suffering from certain kidney problems including: kidney stones
(nephrolithiasis) and calcium deposits in your kidney tissue (nephrocalcinosis).
Warnings and precautions
If you suffer from a kidney disease, only take Calvive after consulting your doctor,
and especially if you are taking preparations containing aluminium.
- Do not take vitamin D products together with Calvive without medical advice.
Other medicines and Calvive
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a medical prescription because calcium can interact with certain other medicines if taken at the same time. • If you are taking, or have recently taken, cardiac glycosides, thiazide diuretics, or corticosteroids, you must follow your doctor’s instructions carefully.
- If you are taking oral bisphosphonates or sodium fluoride, take Calvive at least 3 hours after these medicines.
- If you are taking one of a group of antibiotics called tetracyclines, take Calvive at least 2 hours after or 4-6 hours before the tetracycline. Calvive with food and drink
Calvive should not be taken within 2 hours of eating foods high in oxalic or phytic acid such as spinach, rhubarb and whole cereals. Pregnancy and breast-feeding
- Ask your doctor or pharmacist before taking Calvive if you are pregnant or breast-feeding. • Calvive can be used during pregnancy and breast-feeding in case of a calcium deficiency. In general, the adequate daily intake (including food and supplementation) for pregnant and breast-feeding women is 1000 – 1300 mg calcium.The total daily intake of calcium during pregnancy and breast-feeding should not exceed 1500 mg. • Calcium passes into breast-milk but has no negative effect on the baby.
Driving and using machines
- There is no known effect on the ability to drive or operate machines caused by taking Calvive. Calvive contains aspartame, sodium, sorbitol, benzyl alcohol, sulphur dioxide and glucose.
- Calvive is suitable for diabetics (1 effervescent tablet of 1000 mg contains 0.002 Carbohydrate Units).
- This medicine contains 136.90 mg of sodium (main component of cooking/table salt) in each effervescent tablet. This is equivalent to 6.9 % of the recommended maximum daily intake of sodium for an adult.
This medicine contains 180 nanogram benzyl alcohol in each effervescent tablet. Benzyl alcohol may cause allergic reactions. Benzyl alcohol has been linked with the risk of severe side effects including breathing problems (called “gasping syndrome”) in young children. Do not give to your newborn baby (up to 4 weeks old), unless recommended by your doctor. Do not use for more than a week in young children (less than 3 years old), unless advised by your doctor or pharmacist. • Ask your doctor or pharmacist for advice if you are pregnant or breast-feeding. Ask your doctor Package leaflet: Information for the patient
Calvive 1000
Effervescent Tablets Calcium
or pharmacist for advice if you have a liver or kidney disease. This is because large amounts of benzyl alcohol can build-up in your body and may cause side effects (called “metabolic acidosis”).
- This medicine contains 210 nanogram sulphur dioxide that may rarely cause severe hypersensitivity reactions and bronchospasm. • This medicine contains 30 mg aspartame (E 951) in each effervescent tablet.Aspartame is a source of phenylalanine. It may be harmful if you have phenylketonuria (PKU), a rare genetic disorder in which phenylalanine builds up, because the body cannot remove it properly. • This medicine contains 630 microgram sorbitol in each effervescent tablet.
- This medicine contains glucose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. It may be harmful to the teeth.
3. How to take Calvive
As with all medicinal products, please follow all of the instructions carefully to ensure that Calvive works properly.
For Calvive 1000 mg:
- Children and adults take one effervescent tablet (one single dose) once per day. Dissolve Calvive in a glass of water
(approximately 200 ml) and drink immediately. Do not swallow or chew the tablet.
Calvive can be taken with or without food (see the section "Taking Calvive with food and drink" for further advice).
How long should you take Calvive
Take Calvive at the recommended daily dose for as long as you are advised by your doctor.As Calvive is used in the prevention and treatment of calcium deficiency and, taken with other medicines, in the prevention and treatment of a condition called osteoporosis (weakening of the bones), it is likely this will be a long term treatment.
If you take more Calvive than you should
Overdose of Calvive may lead to symptoms such as nausea, vomiting, thirst or constipation. If overdose is suspected, contact your doctor or pharmacist immediately.
If you forget to take Calvive
Do not take a double dose to make up for a forgotten dose.
4. Possible side effects
Like all medicines, Calvive can cause side effects although not everybody gets them.
Very rare side effects (occur in less than 1 in 10’000 people) include:
- severe allergic reactions such as swelling of the face, lips, tongue and/or throat, which may cause difficulty in swallowing. If you experience any of the above listed allergic reactions, STOP taking Calvive and tell your doctor immediately.
Rare side effects (occur in less than 1 person out of 1’000) include:
nausea, diarrhoea, abdominal pain, constipation, flatulence, vomiting, itching, redness and/or burning of the skin.
Uncommon side effects (occur in less than 1 person out of 100) may include:
- excessive calcium level in the blood (hypercalcaemia) or excessive excretion of calcium in the urine (hypercalciuria). Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
5. How to store Calvive
Keep out of the sight and reach of children. • Expiry date:
Do not take Calvive after the expiry date stated on the box and on the tube after "EXP". The expiry date refers to the last day of that month. • Storage conditions:
Store in the original package and keep the tube tightly closed.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.
6. Contents of the pack and other information
What Calvive contains
The active substances are calcium lactate gluconate and calcium carbonate.
- Each tablet of 1000 mg contains 2263 mg of calcium lactate gluconate and 1750 mg of calcium carbonate (equivalent to 1000 mg of calcium). The other ingredients are: citric acid anhydrous, orange flavouring (contains benzyl alcohol, sorbitol (E 420), glucose and sulphur dioxide (E 220)), aspartame (E 951), macrogol 6000 and sodium hydrogen carbonate.
What Calvive looks like and contents of the pack
The effervescent tablet is white and circular with a characteristic orange odour.
Calvive 1000 mg is available in packs of 30 effervescent tablets.
Not all pack sizes may be marketed
Marketing Authorisation Holder:
Manufacturer:
Haleon UK Trading Services Limited, Building 5, First Floor, The Heights, Brooklands, Weybridge, KT13 0NY, United Kingdom
Haleon UK Trading Limited, Weybridge, KT13 0NY, U.K.
Trade Marks are owned by or licensed to the Haleon group of companies.
This leaflet was last revised in December 2023.
GB 320758 – DN502004/GB-180