Patient leaflet - Adiuretin 0.1 mg / ml nasal spray, Desmopressin 0.1 mg / ml nasal spray
1. What Desmopressin Nasal Spray is and what it is used for
Desmopressin Nasal Spray is a solution for nasal use only. It contains Desmopressin acetate, an antidiuretic (reduces urine production). It is used:
- to treat patients with multiple sclerosis suffering from nocturia (the need to get up at night to pass urine), when other treatments have failed.
- to diagnose and treat cranial diabetes insipidus (a condition which causes extreme thirst and continuous production of large volumes of dilute urine). IMPORTANT: This should not be confused with diabetes mellitus (sugar diabetes).
- as a test to check if the kidneys are functioning properly (renal function test).
2. Before you use Desmopressin Nasal Spray
There are general restrictions, precautions and warnings which apply to all patients using Desmopressin Nasal Spray and there are additional restrictions, precautions and warnings which apply depending on the use of Desmopressin Nasal Spray.
General restrictions (all patients)
Do not use Desmopressin Nasal Spray if:
- you have a serious heart or kidney disease
- you are taking diuretics (water tablets)
- you are allergic to any of the ingredients listed in section 6 of this leaflet
you drink unusually large quantities of fluids, including alcohol.
3. How to use Desmopressin Nasal Spray
PATIENT INSTRUCTIONS
It is important to use your medicine as directed by your doctor. The pharmacy label on the bottle will tell you when to use your medicine and how much to use. If it does not, or you are not sure, ask your doctor or pharmacist.
How to use Desmopressin Nasal Spray
- 1. Remove the protective cap.
- 2.
When first used, prime the spray
by pressing several times until a
consistent, fine spray is seen.
- 3.
Ensure that the dip-tube is in the
liquid when using Desmopressin
Nasal Spray. With your head tilted
slightly back, place the nozzle
just inside the nostril.
- 4.
Hold your breath (DO NOT SNIFF)
and press the spray once.
- 5.
Repeat this procedure using
alternate nostrils until the
prescribed dose is reached.
- 6.
Replace the protective cap
after use.
- 7.
Do not store above 25°C. Keep the
container in the outer carton.
- 8.
If the spray is not used within 7
days of the previous dose, re-prime
by pressing the spray at least once
before using.
Do NOT use more than the prescribed dose in any 24 hour period.
If you have the impression that the effect of Desmopressin Nasal Spray is too strong or too weak, talk to your doctor or pharmacist.
The usual doses are:
Nocturia (the need to get up at night to pass urine) caused by multiple sclerosis:
Your doctor will prescribe a dose of one or two sprays at bedtime. If your dose is two sprays, use one spray in each nostril. The prescribed dose should NOT be used more than once in any 24 hour period. Your doctor will check your blood pressure and weight at regular intervals. Diagnosis of diabetes insipidus (adults and children)
Your doctor will prescribe a dose of two sprays. Use one spray in each nostril.
Treatment of diabetes insipidus
Your doctor will prescribe the dose most suitable for you. The most common dosing in adults and children is one or two sprays into the nostril, once or twice daily. Use one spray in each nostril if your dose is two sprays.
Renal function test
To check if the kidneys are functioning properly, your doctor will prescribe the following single dose:
Adults: Two sprays into each nostril
Children (1-15 years): One spray into each nostril Infants (to 1 year): One spray into one nostril
If you use more Desmopressin Nasal Spray than you should
If you have used more Desmopressin Nasal Spray than you should, talk to your doctor or pharmacist immediately.
If you forget to use Desmopressin Nasal Spray
Do not use a double dose to make up for a forgotten dose. If you are a patient with nocturia caused by multiple sclerosis, do not use Desmopressin Nasal Spray until the usual time for your next dose.
If you are a patient with diabetes insipidus, please consult your doctor or pharmacist for advice.
4. Possible side effects
Like all medicines, Desmopressin Nasal Spray can cause side effects.
you are being treated with Desmopressin Nasal Spray, as this could lead to a build up of water which dilutes salt in the body. This is a serious problem and may lead to convulsions.
STOP USING Desmopressin Nasal Spray if you experience:
- unusually bad or prolonged headache, confusion, unexplained weight gain, ankle swelling, nausea or vomiting
- itching, skin rashes, swelling of the face, lips or throat, difficulty in breathing, wheeziness, chest tightness or coughing (signs of allergic reactions)
If you experience any of the above side effects, you should contact your doctor or go to the nearest casualty department immediately.
Most people using Desmopressin Nasal Spray find it causes them no problems. However, common side effects can include:
- headache
- stomach pain
- blocked or runny nose, nose bleeds
Very rare cases of emotional disorders including aggression in children have also been reported. If you experience one or more of these side effects or any other undesirable effects, please inform your doctor or pharmacist.
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme (website: www.mhra.gov.uk/yellowcard). By reporting side effects you can help provide more information on the safety of this medicine.
5. Storing Desmopressin Nasal Spray
Keep Desmopressin Nasal Spray out of the reach and sight of children.
Do not store above 25°C. Keep container in the outer carton. Use by date: Do NOT use Desmopressin Nasal Spray past the expiry date on the packaging. The expiry date refers to the last day of that month.
If you are unsure about the storage, ask your pharmacist. It is best to return all old and unused medicines to your pharmacist for safe disposal.
6. Further information
Your medicine is called Desmopressin Nasal Spray. It is a solution for nasal use only.
- It is presented in a glass vial with a pump spray device. Each vial contains a volume of 6ml to allow the delivery of 60 sprays
- Each spray contains 10 micrograms of the active ingredient, Desmopressin acetate
- Other ingredients in Desmopressin Nasal Spray are citric acid monohydrate, disodium phosphate dihydrate, sodium chloride, benzalkonium chloride solution 50% and purified water.
Marketing Authorisation Holder:
Ferring Pharmaceuticals Ltd
Drayton Hall, Church Road, West Drayton, UB7 7PS, UK
Manufacturer:
Ferring GmbH
Wittland 11, D-24109 Kiel, Germany
Distributor:
Aspire Pharma Limited
Unit 4, Rotherbrook Court, Bedford Road, Petersfield, Hampshire, GU32 3QG, United Kingdom
Desmopressin Nasal Spray PL 03194/0090
This leaflet was last revised in February 2017
1010307-P2.2
BAC ref: U125 (formerly S821)